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Prevalence of hyperuricemia and its correlation with cardiovascular risk factors in Iraqi subjects of karbalaa city.
إنتشار الارتفاع الحاصل في الحامض البولي وإرتباطه بعواملِ الخطرِ القلبية الوعائيةِ عند الاشخاص العراقيين مِنْ مدينةِ كربلاء.

Author: Hedef D. El-Yassin هدف ظافر الياسين
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2012 Volume: 54 Issue: 1 Pages: 83-87
Publisher: Baghdad University جامعة بغداد

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Abstract

Background Uric acid an independent risk factor for cardiovascular mortality is still disputed as several studies have suggested that hyperuricemia is merely associated with cardiovascular diseases because of confounding factors such as obesity, dyslipidemia, hypertension, use of diuretics and insulin resistance .Moreover, there is still no well-established pathophysio-logical link between hyperuricemia and the development of cardiovascular complicationsObjectives: The purpose of the present study is to investigate the prevalence and the clinical correlation of hyperuricemia with cardiovascular risk factors in Karbalaa city in Iraq.Subjects and method: The investigations were performed between October 2009 and June 2010 on 130 subjects of different ages who attended the public clinic in AL- Hussainy teaching hospital in Karbala. Total cholesterol and triglycerides were determined enzymaticaly. High density lipoprotein-cholesterol was measured similarly after precipitation with magnesium phosphotungstate. Fasting blood glucose was obtained using enzymatic oxidation method. Uric acid was determined using enzymatic methods Results: 19% of the subjects had the elevated level of serum uric acid. In the current study, positive correlations was found between serum uric acid levels and body mass index, plasma glucose, total and low density lipoprotein - cholesterol and triglyceride levels but a negative correlation between uric acid level and high density lipoprotein -cholesterol level.Conclusion: In conclusion, these data show that hyperuricemia is closely linked to the various components of the metabolic syndrome and independently related to coronary artery disease.

الارتفاع الغير طبيعي للحامض البولي هي حالة مرضية حاصلة نتيجة الانتاج المتزايد للحامض او قلة في طرح هذا الحامض عن طريق الجسم او بسبب كلتا الحالتين . الحامض البولي هو الناتج النهائي لل purine الموجود في الجسم .أثناء سنِ الرشد، يَزِيدُ تركيزَ بلازما الحامضِ البوليِ بشكل إضافي وهذه الزيادةِ تتفاوت حسب الاختلاف الحاصل بالطول ، وزن جسمِ، ضغط دمّ، وظيفة الكلى، استخدام الكحول والحميةَ الغذائية . .الحامض البولي عاملُ خطرِ مستقلِ للفناءِ القلبي الوعائيِ ما زالَ قيد البحث بينما إقترحتْ عِدّة دِراسات بأنّ ارتفاع الحامض البولي اُرتَبطُ بأمراض الأوعية القلبيةِ بصورة مجردة بسبب تَفنيد العواملِ الاخرى مثل السمنةِ , اختلال نسبة الدهون في جسم الانسان, إرتفاع ضغط الدم، مقاومةِ عمل الأنسولينَ في الجسم استعمال مدرّراتَ البول علاوة على ذلك، ما زالَتْ هنالك صلة غير واضحة و راسخة بين ارتفاع نسبة مصل الحامض البولي وتطوير التعقيداتِ القلبية الوعائيةِالهدف:إنّ غرضَ الدراسةِ الحاليةِ هي التحري عن الإنتشارَ والإرتباطَ السريريَ لارتفاع مصل الحامض البولي و عواملِ الخطرِ القلبية الوعائيةِ في مدينةِ كربلاء في العراق، في محاولةِ للتَغَلُّب على مثل هذه العواملِ التي لَرُبَّمَا يَكُون لَهُ تأثير تدميري جماعي على الصحة العامةِ.المرضى والطرق: تم العمل بالبحث للفترة من أكتوبر/تشرين الأولِ 2009 - يونيو/حزيران 2010 في 130 مِنْ الاشخاص باعمارِ المختلفةِ التي حَضرتْ العيادةَ العامّةَ في مستشفى الحسيني التعليمي في كربلاءكولسترول وكولسترول عالي الكثافة تم قياسه بالاضافة الى قياس كولسترول HDL بالاضافة الى قياس مصل الحامض البولي, تمت قياس هذة التحاليل بعد قياس وحدة كتلة الجسم النَتائِج والمُناقشة:المسح نفّذَ بين سكانِ مدينةِ كربلاء يُظهر بأنّ بَعْض الاشخاص لَها قِيَمُ عاليةُ للبارامتراتِ إختبرتْ أَيّ تَجْعلُهم ضمن خطرِ المتلازمةِ الأيضيةِ المدعوةِ.9 % من الاشخاص تظهر أَنْ يَكُونَ عِنْدَهُ تركيز عالي لمصل للحامضِ البوليِ وفي بَعْض الحالاتِ المرضية بنسب متشابهة تقريبا مما يجعل ارتفاع مصل الحامض البولي عامل خطرِ فعّالِفي الدراسةِ الحاليةِ، وُجِدَ إرتباطاتَ إيجابيةَ بين حامضِ المصلِ البوليِ و كتلة الجسم ، بلازما كلوكوز ، بالاضافة الى العلاقة الايجابية بين كولسترول وكولسترول عالي الكثافة وكولوستيرول LDL , اضافة الى ذللك هنالك إرتباط سلبي بين المستوى الحامضيِ البوليِ ومُستَوَى كُولِسترولِ HDL نتيجةً لذلك، اظهرت البياناتِ بأنّ ارتفاع مصل الحامض البولي مرتبط بشكل وثيق بالمكوّناتِ المُخْتَلِفةِ للمتلازمةِ الأيضيةِ وتَعلّقتْ بأمراضِ الشريانِ التاجيةِ بشكل مستقل


Article
Effect of aging on growth hormone-leptin axis in normal andobese healthy subjects

Authors: Hedef D. El-Yassin --- Zaineb A. Razak Al-Sharifi (
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 3 Pages: 383-390
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Growth hormone is a hormone responsible for the normal body
growth and development by stimulation protein production in muscle cells and
energy release for breakdown of fat. On the other hand leptin is a newly discovered
hormone that is mainly synthesized in adipose tissues it decreases food intake by
causing satiety and promoting energy combustion . Both aging and obesity are
associated with a reduction in growth hormone secretion. In the mean time obese
humans have increased circulating leptin.
Objective: The aim of this paper is to shed light on the contribution of these two
hormones in the mechanism of aging process in an attempt of improving this
process for a better life at old ages.
Subjects and methods: Two hundred and seventy healthy subjects aged 25-64
years old participated in this study. The subjects' were divided into four groups
according to their ages and to three groups according to their weights. Urine
analysis from each subject was carried out to exclude diabetes and renal failure.
Sera from blood samples were used to carry out certain biochemical parameters and
hormone (growth hormone and leptin).
Results: The results obtained show a decrease in the level of growth hormone with
progression of age. In the mean time there is an increase in the level of serum leptin
with the advancement of age. Aging is usually associated with adiposity. Increasing
fat with age is probably multifactorial one potential mechanism for that is reduced
leptin transport across blood-brain barrier..
Conclusion: The increase in leptin level which was observed in elderly age group
and obese group suggest that the associated decrease in growth hormone serum
level is related to obesity in general and in particular to the aging process.

Keywords

growth hormone --- leptin --- obesity --- aging.


Article
exercise induced growth hormone and the effect of age and oxidative stress parameters in Iraqi subjects

Author: hedef D.El-Yassin أ.د . هدف ظافر الياسين
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 1 Pages: 67-72
Publisher: Baghdad University جامعة بغداد

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Article
Obesity and resistin'. What is the link?

Author: hedef D.El-Yassin د. هدف ظافر الياسين
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2005 Volume: 47 Issue: 2 Pages: 102-104
Publisher: Baghdad University جامعة بغداد

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review article


Article
Serum resistin levels, and other hormonal and biochemical parameters in patients with polycystic ovary syndrome (PCOS)

Authors: Haider Al – Shammaa** FIBCOG --- Hedef D. El – Yassin* PhD --- Kamila H. Shamam* MSc
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 2 Pages: 200-203
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Polycystic ovarian syndrome (PCOS) is one of the most common cause of anovulation during reproductive life.Resistin can increase ovarian androgen production by directly stimulating ovarian theca cell or indirectly by augmenting pancreatic – B cell production of insulin.Patients and Methods: Sixty patients with PCOS who were non diabetic and not taking any medicine for the last three months were involved in the study .Thirty normal fertile female serves as control group. Fasting blood samples were aspirated from all individuals from 3rd - 6th day of the menstrual cycle to measure resistin, insulin, glucose, LH, FSH, TT3, TT4, Prolactin , Total Testosterone and lipid profile, by ELISA and routine methods.Results: mean serum resistin concentration was increased in women with PCOS compared with the control group (Mean ±SD) (19.83 ± 6.101 vs 9.36 ± 2.17) ng/ml. Serum resistin concentration correlated positively with BMI, which is divided into two subgroups. The first with BMI < 25 kg/m2 and the second with BMI &#8805;25kg/m2 in both control and patient groups. In BMI < 25kg/m2 serum resistin concentration for the control group was (8.90 ± 1.76) and (14.66 ± 2.09 ) for patients group ,while BMI &#8805; 25 kg/m2 serum resistin concentration for the control group was (10.62 ± 1.76) and (21.55 ± 5.40) ng/ml for patients group. Resistin also correlated positively with Insulin, LH, LH/FSH ratio and total Testosteron in women with PCOS but not in control. Fasting insulin level was higher in PCOS group compared with the control group (Mean ±SD) (27.45 ± 4.47 vs 13.27 ± 3.80) mIU/ml.The Fasting serum glucose was also higher in PCOS group compared with the control group (Mean ±SD) (125.27 ± 28.63 vs 92.63 ± 13.99) mg/dl. Total Testosterone level was elevated in the PCOS group compared with the control group (1.04 ± 0.37 vs 0.52 ± 0.25) ng/ml.Total Testosterone correlated positively with BMI, Resistin, Insulin, LH, and LH/FSH ratio.Conclusion: PCOS women with BMI >25 kg/m² were found to have a marked increase level of Resistin ,Insulin , Glucose ,LH ,and Total Testosterone .and a decrease level in their insulin sensitivity i.e increased insulin resistance.These data indicate that abnormal resistin secretion in obese PCOS women may play a role in causing ovarian hyperandrogenism and hyperinsulinemia. Therefore fasting serum resistin level could be helpful in diagnosing PCOS patient


Article
The impact of inflammation on Resistin, Insulin and Troponin I in Acute Myocardial Infarction patients
تأثير التهاب في رزيستين، الأنسولين وتروبونين أنا في مرضى احتشاء عضلة القلب الحاد

Authors: Ammal E. Ibrahim امال اسماعيل ابراهيم --- Hedef D. EL-Yassin --- Hamid K. AL-Janabi
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2011 Volume: 53 Issue: 3 Pages: 338-342
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Myocardial Infarction (MI) is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue may play an important role in mediating this chronic inflammatory process. Inflammatory responses are involved in the initiation and progression of atherosclerotic plaques. Resistin is a cysteine-rich polypeptide that is expressed at relatively lower levels in human adipocytes but higher levels in macrophages. Insulin is an important hormone as it regulates the level of glucose, in the blood. This protein is formed in specialized cells of the pancreas called beta islet cells.Subjects and Methods:The study included 50 patients with AMI and fourty healthy subjects as controls. levels of resistin, insulin and troponin were measured.Results: The levels of resistin and insulin were significantly elevated with (p<0.001), there was a positive correlation between resistin with insulin and troponin in acute myocardial infarction.Conclusions: There was a significant increase in the levels of resistin, in acute myocardial infarction patients and this increase may be related to inflammation. Elevated levels of resistin can lead to glucose intolerance in AMI patients.

خلفية: احتشاء عضلة القلب (MI) هو الأكثر شيوعا نظرا لانسداد (انسداد) في الشريان التاجي بعد تمزق لوحة تصلب الشرايين عرضة للخطر. وقد اقترح أن الأنسجة الدهنية قد تلعب دورا مهما في التوسط في هذه العملية التهابي مزمن. وتشارك الاستجابات الالتهابية في بدء وتطور لويحات تصلب الشرايين. رزيستين هو ببتيد السيستين الغنية التي أعرب عنها في مستويات منخفضة نسبيا في adipocytes الإنسان، ولكن مستويات أعلى في الضامة. الأنسولين هو هرمون مهم لأنه ينظم مستوى السكر في الدم. ويتكون هذا البروتين في الخلايا المتخصصة في البنكرياس تسمى خلايا بيتا جزيرة. المواضيع والأساليب: وشملت الدراسة 50 مريضا مع AMI ومواضيع صحية وأربعين الضوابط. تم قياس مستويات رزيستين، الأنسولين وتروبونين. النتائج: كانت مرتفعة بشكل ملحوظ في مستويات الانسولين ورزيستين مع (P <0.001)، وكان هناك ارتباط إيجابي بين رزيستين مع الانسولين وتروبونين في احتشاء عضلة القلب الحاد. الاستنتاجات: كان هناك زيادة كبيرة في مستويات رزيستين، في الحاد مرضى احتشاء عضلة القلب، وربما يرجع ذلك إلى زيادة الالتهابات. يمكن أن مستويات مرتفعة من رزيستين يؤدي إلى الحساسية المفرطة تجاه الجلوكوز في المرضى الذين يعانون AMI.


Article
GLUTATHION, GLUTATHION REDUCTASE AND GAMA-GLUTAMYL TRANSFERASE BIOMARKERS FOR TYPE 2 DIABETES MELLITUS AND CORONARY HEART DISEASE

Authors: Hedef D El-Yassin هدف ظافر الياسين --- Zainab AA Al-Shamma زينب عبد الامير الشماع
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2011 Volume: 9 Issue: 3 Pages: 218-226
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

BackgroundHypercholesterolemia, one of the major risk factors of atherosclerosis, is a major health problem in the world that enhances the free radical generation in various ways. The level of antioxidants was decreased in hypercholesterolemic patients. This depletion of antioxidants may increase in type 2 diabetic patients with hypercholesterolemia, which also may increase the risk of complications from the most common form of diabetes mellitus.ObjectiveTo evaluate serum reduced glutathione and glutathione reductase as an antioxidant, and gamma-glutamyl transferase as a marker of oxidative stress in both hypercholesterolemic and diabetic-hypercholesterolemic patients.MethodsThe study involved 33 diabetic hypercholesterolemic patients, 37 hypercholesterolemic and 54 healthy control subjects. Ten ml of blood were collected from each patient and normal control subject after an overnight fast for the measurement of gluathion (GSH) glutathione reductase (GR) and gamma-glutamyl transferease (GGT), glucose, lipid profile, urea, creatinine and glycated Hb (HbA1c). The last was for the diabetics only.ResultShowed a significant decrease in GSH and GR in diabetic-hypercholesterolemic patients compared with hypercholseterolemic patients and a significant increase in GGT in both groups compared with controls. There was a negative correlation between cholesterol with GR in both groups of patients involved in this study and a negative correlation between HbA1c and each of GSH and GR in the diabetic-hypercholesterolemic patients.ConclusionsHigh levels of oxidative stress and reduced antioxidants in people with coronary heart disease, previously thought to be markers of the heart condition, could also, indicate a condition of glucose abnormality, such as overt type 2 diabetes.Key wordshypercholestermia, type 2 diabetes, antioxidants, oxidative stress, GGT.


Article
Unstable Angina Biomarkers and Their Main Risk Factors in Iraqi Patients

Authors: Ammal E. Ibrahim امال ابراهيم --- Hiba A. Hasan هبة حسن --- Hedef D. El-Yassin هدف الياسين
Journal: Al-Mustansiriyah Journal for Pharmaceutical Sciences مجلة المستنصرية للعلوم الصيدلانية ISSN: 18150993 Year: 2012 Volume: 11 Issue: 1 Pages: 92-99
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract:The presented study focuses on the main role of leptin and lipid profilelevel in Iraqi patients with unstable angina to indicate the main risk factors thatplay a role with their elevation.This is a case control study conducted on (37) unstable angina patientsand (20) healthy control who were closely similar by age, gender and BMI.The main statistical analysis used was student t test, linear regression testand correlation test. Significance was set at P < 0.05. Sampling method used forthis study was convenience sampling method.The main results of this study showed that leptin and lipid profilespecifically LDL, TG, TC and VLDL are the main biomarker for the futureincidence of unstable angina in Iraqi patients. Doctors should focus on bothleptin level and lipid profile level as biomarkers for future incidence of unstable

ألخلاصة:تهدف هذه الدراسة لتوضیح دور مستوى هرمون اللبتین والدهون عند المرضى العراقیینالمصابین بالذبحة الصدریة غیر المستقر ة و كذلك لتحدید عوامل الخطورة الاساسیة التي تتسبب فيارتفاعهما.تشتمل هذه الدراسة على ( 37 ) مریض مصاب بالذبحة الصدریة غیر المستقر ة و ( 20 ) منالأشخاص الأصحاء المتقاربین بكل من العمر والجنس وكتلة الجسم.اختبار الارتداد الخطي واختبار ,t التحلیل الإحصائي المستخدم في هذه الدراسة هو اختبار.p< العلاقة. تعتبر الزیادة معنویة إذا كانت قیمة 0.05طریقة جمع العینات كانت بواسطة طریقة الانتقاء المریح. أظهرت النتائج الاساسیة لهذه الدراسةهي العوامل HDL لكن لیس VLDL و LDL, TG, TC هي إن اللبتین و مستوى الدهون وخصوصاالبیولوجیة الرئیسیة في حدوث ألذبحة ألصدریة غیر المستقر ة المستقبلیة عند المرضى العراقیین.


Article
Thyroid Disorders and the Level of Malondialdehyde

Authors: Eham A. Ali * PhD PhD --- Yildiz H. Tahseen** --- Hedef D. El-Yassin** PhD هدف ظافر الياسين
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 1 Pages: 67-70
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Free radicals have been implicated in many pathological processes, includingischemia, inflammation, and malignancy. The free radicals may affect tissues damage by lipidperoxidation which generate malondialdehyde (MDA) as a by byproduct of the reaction. Theobjective of this study is to examine the dynamics of lipid peroxidation in patients withthyroid disorders using the measurement of malondialdehyde level as a marker for the degree ofthyroid disorder.Methods: Two hundred and forty five subjects were enrolled in this study. Hundred andninety five were patients with different thyroid disorders (88 yperthyroidism, 63hypothyroidism and 44 thyroid carcinoma) the remaining 50 subjects were healthy oneswithout any apparent functional disorders served as a control. Malondialdehyde (MDA) levelwas estimated in the sera of all subjects.Results: A significant increase in the level of serum MDA concentration was observed inpatients with all types of thyroid disorders as compared with the control groups.Conclusion: The findings obtained showed a high


Article
the role of hyperlipidemia on nerve conduction

Authors: shaymaa J. Al- Shareefi --- hedef D.El-Yassin هدف ظافر الياسين --- Abdul-Raheem H.Dawoud
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 1 Pages: 105-109
Publisher: Baghdad University جامعة بغداد

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