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Article
Histopathological and Histochemical Changes of the Popliteal Artery in Diabetic Patients

Authors: Payman Jamal Muhamad Ameen --- Talib Jawad Kazim --- Hewa Baker
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2014 Volume: 7 Issue: 1 Pages: 8-17
Publisher: Diyala University جامعة ديالى

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Abstract

Back ground: A lot of previous researches studded the endoneural microangiopathy and small vessels diabetic pathological change, but little studded about the diabetic angiopathy of the larger vessels like popliteal artery and related diabetic risk factors .Accordingly the present work designed to study the structural and histochemical changes of the popliteal artery as one of the medium size vessels.Objective: Evaluation of the histopathological and histochemical measurement, of the popliteal artery in diabetic male and female patients with different duration of the diseases, in comparison with normal non diabetic samples. Patient and methods: Histological sections, taken from amputated legs of 30 diabetic patients (8 females and 22 males) at age of (55-75) years, and 30 cadavers (4 females and 26 males) at age of (25-50) years as control group. Results: Histological sections from the popliteal artery of diabetic patients, showed marked decrease in the diameter of the lumen, reduced thickness of tunica media and adventitia, but increase in the thickness of tunica intimae and basement membrane. The loss of endothelium in some places, cellular infiltrations in tunica media with Periodic Acid Schiff positive particles, and in more advance cases calcifications, and organized thrombus was also detected. The multiple regression analysis, showed significant effect of duration of diabetes on the diameter of the lumen, and thickness of the wall and the tunica intima and media of the popliteal artery.


Article
Neuropathic Changes of Osmicated Common Peroneal and Tibial Nerve in Diabetic Patients and the Related Risk Factors

Authors: Payman Jamal Muhamad Ameen بيمان جمال محمد امين --- Talib Jawad Kathum طالب جواد كاظم --- Hewa Baker هيوا بكر
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2011 Volume: 1 Issue: 2 Pages: 68-77
Publisher: Diyala University جامعة ديالى

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Abstract

So much studies done to present the diabetic neuropathic changes of the peripheral nerves but most of them were done experimentally on laboratory animals , but little about human diabetic neuropathic and structural changes specially of large nerves like common peroneal and tibial nerve .Accordingly the present work designed to study the neuropathic changes of the tibial and common peroneal nerve samples, taken from amputated legs of 30 diabetic patients (8 females and 22 males) at age ranging between (55-75) years, and from 30 cadavers (4 females and 26 males) at age ranging between (25-50) years as control group. The teased and osmicated tibial and common peroneal nerve fibers, and histological sections taken from diabetic patients showed different deformity and Morphometrical changes, of that ; paranodal swelling, segmental demyelination, some areas with an areas of un even myelin and shortest segmentation the (common peroneal nerve 22μ and tibial nerve 265μ ) in comparison to the control group. The multiple regression analysis, showed significant effect of age of the patient and duration of diabetes on the neuropathic changes.

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