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FREQUANCY OF ABO AND RHESUS INCOMPATIBILITY IN NEONATAL JAUNDICE
نسبة انتشار ABOو RHعدم التوافق في الأطفال حديثي الولادة المصابين باليرقان الولادي

Author: Hithab jawad muhsen
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2017 Volume: 15 Issue: 4 Pages: 255-260
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: jaundice is the commonest medical condition affecting infants in first week of life. the cause is bilirubin deposition in the skin. jaundice in newborn is a result of increased RBC destruction and decreased bilirubin elimination. Aim of study: The aim of this study is prescribe the frequency and severity of Rh and ABO incompatibility in neonates admitted to Pediatrics & Neonatology unit, al-Zahraa teaching Hospital, Najaf, Iraq.Patients and methods: This descriptive study done in neonatal intensive care unit, in al- Zahraa teaching hospital ,Najaf ,Iraq. 300 neonate admitted to neonatal unit from period of first of May 2014 to august 2014 with jaundice were included in the study.Results: from 300 neonate with jaundice , 144( 48%) were female and 156( 52% ) male , the frequency of ABO , combined ABO and RH and RH incompatibility in neonates with jaundice was 99(33%), 36(12%), 51 ( 17%) respectively .15(22.7%) of neonate with ABO and 21( 31.8%) with RH incompatibility treated with exchange transfusion. While 4 (1.3 %) and 10 (3.3 %) of patient with ABO and RH incompatibility respectively developed sign of kernicterus on discharge. Conclusion: out of 300 neonate presented with jaundice , most common hemolytic cause was ABO-incompatibility 99( 33%), followed by Rh –incompatibility 51(17%), Rh –incompatibility is more severe than ABO , 21(31.8%) of patients with RH incompatibility treated with exchange transfusion and 10(3.3%) of them discharge with sign of kernicterus

الخلفية: تحديد مدى حدوث حالات عدم التوافق لل- ABO and RH في الأطفال حديثي الولادة المصابين باليرقان وتقدير الخطورة لكل الأنواع المختلفة من اليرقان الولاديالطريقة: دراسة وصفية في المستشفى اجريت في وحدة العناية المركزة لحديثي الولادة في م.الزهراء ,نجف,عراق, 300 ادخلوا إلى الوحدة من الفترة بين آذار 2014 الى أب 2014 مشخصين سريريا باليرقان الولادي ادخلوا الدراسة.النتائج: من 300 طفل حديث الولادة مصابين باليرقان الولادي 156% كانوا ذكور و48% اناث نسبة حدوث ,ABO and RH ABOمعا ,RH في هذه الدراسة كان 33%,12%,17% بالتعاقب و38% للأسباب الاخرى وتشمل اليرقان الفسلجي ,G6PD , وتعفن الدم. 22.7% من الاطفال مع ABO و 31.8% مع RH عولجوا بتبديل الدم بينما 1.3% و3.3% من المرضى مع ABO و RH بالتعاقب اظهروا علامات ضرر الدماغ(كيرنكترس).الاستنتاج: من 300 طفل حديث الولادة مصابين باليرقان الولادي اكثر نوع وجد هو ABO 33% ثم RH 17%. نوع RH اكثر خطورة3.3 % سرحوا مع علامات ضرر الدماغ .التشخيص المبكر والإجراءات الوقائية للأطفال في خطر يقلل من الإصابة بضرر الدماغالمفتاح: زيادة البلروبين ,ضرر الدماغ, ABO,RH نجف -عراق

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Article
The Effect of Birth Asphyxia on the Coagulation Status in Neonates

Authors: Ashwaq Ali Hussein --- Hithab Jawad Muhsen --- Rajaa Jabbar Kadhum
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2017 Volume: 10 Issue: 2 Pages: 2719-2724
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Birth asphyxia has multi system effect, which predisposes to coagulopathy by enhancing consumption of platelets & some clotting factors as a results of the associated sever hypoxemia, acidaemia & sepsisObjective: To study the effects of birth asphyxia & perinatal events on the coagulation status of newborn infants. Patients & Methods: Across sectional study was done on 27 neonates with birth asphyxia in AL-Zahraa teaching hospital in Najaf city from period of first of February 2012 to first of July 2012. Blood samples were collected from the neonates within the first 24 hrs. After birth and sent for investigations including PT, PTT, plasma fibrinogen and platelet count.Results: The study showed statistically significant effect of birth asphyxia on platelet count especially in severely asphyxiated neonates with Apgar score of 0 – 3 at 5 min after birth (plat. Count < 100,000 per mm3) in comparison to neonates with Apgar score of 4 – 6 at 5min after birth. Infants who have very low birth wt. (i.e. <1500 gms) had significantly lower platelet count (< 100,000 per mm3) than infants with birth wt.>1500 gmsBirth asphyxia had no significant effect on PT, PTT, or fibrinogen level. Other perinatal and prenatal variables examined as (sex, maternal hypertension, DM, mode of delivery gestational age) did not show any significant association with coagulation status.Conclusion: Thrombocytopenia (plat. <100.000 per mm3) is seen in neonates with Apger score (0-3) at 5 min. and in neonates with very low birth wt. <1500gms). No statistically significant relation between birth asphyxia and PT, PTT and plasma fibrinogen level.

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