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Article
Study Effect of Glimepiride and Repaglinide on CIMT and Long Glycemic Control in Type 2 Diabetic Patients Double Blind Study

Author: Hussein Aziz Naser
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2013 Volume: 10 Issue: 3 Pages: 683-698
Publisher: Babylon University جامعة بابل

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Abstract

Background Diabetes mellitus (DM) is one of the main risk factors for cardiovascular complications ,namely coronary ischemia, Peripheral vascular disease, and stroke. Atherosclerosis is highly associated with Diabetes mellitus . Carotid intima media thickness (CIMT) is used extensively as a method to detect atherosclerosis.Aim of the study repaglinide and glimepiride are newly introduced and used for non–insulin-dependent diabetes mellitus (NIDDM) ,the study aim to compare the difference in their effect on CIMT. Patients and Methods The study enrolled 62 patients NIDDM all from Al Hakeem Diabetic center in Najaf in period from January 2011 to the March 2012 all had their recording files with mean age (53±0.23), 35females and 27 males with body mass index (BMI) Mean( 28±0.4 ) divided into two groups (blindly grouped) each one 31used Repaglinide 3mg/day and second one used Glimepiride 3mg/day. followed after 6 months and then after 12 months record the hemoglobin A1c(HbA1c), lipid profile , CRP, blood pressure ,the blood urea and serum Creatinine and studying the CIMT of both internal carotid and the common carotid arteries using ultrasonic Doppler study .Results There was a significant( p<0.05) reduction in CIMT of left internal carotid and the right common carotid arteries in patients treated with repaglidine compares to those patients treated with glimepiride and there was also reduction in the other parameters Low-density lipoprotein (LDL) , Triglyceride (TG) ,HbA1c still these decrement were not a significant one.Conclusion and recommendation repaglinide is better in reduction of the CIMT than Glimepiride in spite of insignificant reduction in the lipid profile or HbA1c. We recommend to study what dose required to achieve a best reduction in CIMT.

دراسة مزدوجة غير محددة لتاثيرعقار كلمبرايد وعقار رابكليدين على ثخن الطبقة المبطنة الداخلية للشرايين العنقية في النوع الثاني لمرض السكري مرض السكر يشكل احد اخطر عوامل مضاعفات إمراض جهاز الدوران و الأوعية الدموية وبالأخص عدم كفاءة الشرايين القلبية وإمراض الأوعية الدموية للأطراف والجلطة الدماغية إن تصلب الشرايين يتصاحب مع مرض داء السكر وان قياس ثخن الطبقة المبطنة الداخلية للشرايين العنقية يستخدم بشكل واسع للتعرف على تصلب الشرايين-تهدف الدراسة إلى مقارنة الفرق في التأثير بين العقارين على ثخن الطبقة المبطنة الداخلية للشرايين العنقية-شملت الدراسة62مريضا من النوع غير المعتمد على الأنسولين في مركز الحكيم للسكري في الفترة بين كانون الثاني2011واذار2012وكان عمر المصابين بالمتوسط 53,2 سنة وتوزعوا على 35 من الإناث و27 من الذكور وبمعدل كتلة الجسم 28.4وقد وزع المرضى وبشكل غير محدد على مجموعتين 31استخدموا كلمبرايد 3ملغم و31استخدموا 3ملغم رابكلدين تم إعادة فحص ثخن الطبقة المبطنة الداخلية للشرايين العنقية بواسطة جهاز الأمواج فوق الصوتية بعد 6شهور وبعد 12شهرا مع دراسة مستوى الدهون وحساب معدل السكر التراكمي أثبتت النتائج الإحصائية أن عقار رابكليدين أفضل من عقار كلمبرايد في خفض تخن الطبقة المبطنة الداخلية للشرايين العنقية.

Keywords

diabetes --- glimepiride --- repaglinide --- CIMT


Article
Basophil count as predictor to the deep vein thrombosis and the thrombo-embolization

Author: Hussein Aziz Naser
Journal: Muthanna Medical Journal مجلة المثنى الطبية ISSN: 2226146x Year: 2018 Volume: 5 Issue: 2 Pages: 95-106
Publisher: Al-Muthanna University جامعة المثنى

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Abstract

Basophil is one of the granulocytes leukocytes that has many functions, one of them is the secretion of heparin. The aim study is investigated the correlate the basophilic count with the low endogenous heparin and thrombosis in the deep veins and the thromboembolism. A cross-sectional study conducted at Al Sader Medical City (radiology unit, Doppler unit study and emergency room) during the period from December 2015 to February 2017 included 203 patients with diagnosis of deep vein thrombosis (DVT) by Ultrasonic Doppler study or pulmonary embolism (PE) by CT pulmonary angiography. A group of 205 subjects without evidence of DVT were used as a control. One hundred sixty seven patients (82.3%) had DVT for first time, while 14 (6.9%) had recurrent DVT, and 22 (10.8%) had PE. The total male number has thromboembolism disease 52 but total female number is 151 with a male to female ratio was 1: 2.9. At current study founded the basophil percent and basophil count in patient with thromboembolism disease was decreased than normal value, The mean basophil percent in thromboembolism disease was 0.35% ± 0.28% while mean basophil count is 30 ± 26, It had been significantly found that basophil percent and basophilic cell count had a strong association with thromboembolism. Basophil percent had a sensitivity of 82%, specificity 79.5% and accuracy of 80.8%. The corresponding values of these parameters for the basophil count were 85%, 73.2% and 79.1%. In conclusion; both low basophil percent and the basophilic count are significantly associated with DVT, recurrent DVT and PE.

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