Background: Aloe vera is an evergreen perennial plant. It is widely used in modern herbal practice. The clear gel contained within the leaf makes an excellent treatment for wounds, burns and other skin disorders, speeding up the rate of healing and reducing the risk of infection. Aloe vera is also taken internally in the treatment of chronic constipation, poor appetite, and digestive problems. Semen analysis is the cornerstone of the evaluation of male fertility. Routine semen analysis can many times allow a definitive diagnosis of infertility. Therefore, the typical measurements done in a semen analysis include: sperm concentration, sperm motility, progressive sperm motility, sperm morphology, and foreign cell contamination. Objective: The present investigation was carried out to study the effect of low dose of fresh Aloe vera leaf gel extracts on in vitro sperm parameters for asthenozoospermic patients. Materials and Methods: Thirty semen samples of asthenozoospermic patients were used in this study. 5 µL of Aloe vera extract was mixed with 1 ml of each sample, left in the incubator for one hour, and then the sperm parameters including concentration, motility, morphology, agglutination, viability, and HOS test were recorded. Results: Highly significant increase at (P≤ 0.01) was recorded in the sperm concentration, percentages of sperm motility, progressive motility grade A, and normal sperm morphology, as well as sperm viability and HOS test. While a highly significant decrease (P≤ 0.01) was record in the percentages of sperm grades C and D, agglutination, and number of round cells. Conclusion: Using low dose of fresh Aloe vera extract enhanced sperm parameters especially in relation to motility, morphology and viability.

اجريت هذه الدراسة لمعرفة تاثير الجرع الواطئة من مستخلص نبات الصبار Aloe vera على معايير نطف الانسان في الزجاج للمرضى الذين يعانون من وهن النطف. شملت الدراسة ثلاثون عينة مني من مرضى وهن النطف وبعد اجراء تحليل السائل المنوي وفقا للمعايير القياسية لمنظمة الصحة العالمية (WHO, 2010) تمت اضافة 5 مايكروليتر من مستخلص نبات الصبار لواحد مل من السائل المنوي لكل عينة وتركت في الحاضنة لمدة ساعة ثم سجلت معايير النطف والتي شملت تركيز النطف والحركة والنسبة المئوية لشكلياء النطف السوية والتلازن واجراء فحص انتفاخ الغشاء البلازمي للنطفة وحيوية النطف. اظهرت النتائج زيادة معنوية عالية(P≤ 0.01) في معدل تركيز النطف والنسبة المئوية للحركة التقدمية ((A للنطف ونسبة الشكلياء السوية كذلك حيوية النطف كما سجل انخفاض معنوي عالي (P≤ 0.01) في النسبة المئوية للحركة غير التقدمية (C) والنطف غير المتحركة (D) والتلازن وعدد الخلايا الدائرية. يمكن الاستنتاج من الدراسة الحالية بان اضافة جرع واطئة من مستخلص نبات الصبار الى عينات السائل المنوي للمرضى الذين يعانون من وهن النطف لمدة ساعة ادى الى تحسين في معالم ووظائف النطف الرئيسية.

Aloe vera --- male infertility --- sperm --- asthenozoospermia

BackgroundAmong various natural therapeutic remedies, Aloe vera, a medical plant widely used in food supplements, beverages, pharmaceutical and cosmetics. Aloe vera has been widely reported for its numerous medicinal effects.Ob,jertivesThe present investigation was carried out to study the histological changes inthe mice testis consumed low doses of Aloe vera leaf gel extractsMethodsForty immature male Swiss Webster mice divided into two equal groups (experimental and control) (G and C respectively). The experimental group (G) was given 10 µI of Aloe vera extract orally for 21 days. While the control groups (C) were given by the same dose and rout of administration with normal saline only.After Six weeks (around puberty) the male were sacrificed to get their testes; each testis was fixed .Then histological sections with athickness of 5 microns were prepared.ResultsHistological studies of mice testes from groups that consume low dose Aloe vera extracts showed enhanced the entire structure of spermatogenic layer of semineferous tubules that composed of extensive normal arranged germ cells layer.A significant increase in the numbers of spermatogonia, primary spermatocytes and spermatids, rates of normal supporting (Sertoli cells) and Leydig's cells. A significant increase in the rate of height of epithelial cells, and rates of sperms concentration in the semineferous tubules were observed too.ConclusionUsing low dose of Aloe vera extract enhanced the histological structure of male mice testis and may be usefulto produce drugs to improve malefertility.

Aloe vera --- testis --- male reproductive system.