research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
EFFECTS OF SEX HORMONES ON PROSTATE VOLUME IN PATIENTS WITH LOWER URINARY TRACT SYMPTOMS

Authors: Murtatha M Salih --- Jamal A Al-Dohan --- Ihsan S Mahmood
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2013 Volume: 19 Issue: 2 Pages: 19-22
Publisher: Basrah University جامعة البصرة

Loading...
Loading...
Abstract

Ihsan S Mahmood*, Jamal A Al-Dohan@ & Murtatha M Salih$*,@Department of Biochemistry, $Department of Surgery, College of Medicine, University of Basrah, Basrah, IRAQ.Abstract The objective of this study is to investigate the relationship between sex hormone levels and prostate volume in patients with lower urinary tract symptoms (LUTS). This study involved 66 patients suffering from LUTS for more than one month, with age ranged from 36 to 85 years who attended Basrah General Hospital outpatient clinic of urological surgery seeking management, eleven of them were suffering from non-insulin dependent diabetes mellitus (NIDDM). The medical and surgical history were taken through special questionnaire and the severity of LUTS was assessed by International Prostate Symptom Score (IPSS). General and urological examinations were done to them. Four ml of venous blood was drawn from each patient to measure luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone (TT), free testosterone (fT), estradiol (E2) and prostate specific antigen (PSA) and the results were used to assess the presence of any association with IPSS or prostate volume. Also fasting blood sugar, blood urea, serum creatinine and thyroid stimulating hormone (TSH) were measured to identify unknown diabetic patients and exclude those with renal failure or dysthyroidism. Mean±SD of age and prostate volume of the patients were (63.8±9.5) years and (45.5±24.8) ml, respectively. The IPSS and bother scores were (17.3±6.5) and (3.8±1.4), respectively. Mean serum FSH, LH, TT, fT and E2 were (11.5±13.0) mIU/ml, (6.7±5.9) mIU/ml, (4.6±2.4) ng/ml, (6.5±4.8) pg/ml and (47.9±24.4), respectively. Patients with larger prostate volume (>40 ml) had significantly higher mean age and also had higher mean estradiol level after age adjustment (p value <0.05). Prostate volume showed significant correlations with age, PSA and with E2 after age adjustment, but not with IPSS or any of the other sex hormones. The most important other correlation is the negative correlation between total testosterone and IPSS. Diabetes mellitus, hypertension and family history of BPH didn’t seem to have significant effect on prostate volume. In conclusion, age is the main determiner of prostate volume. Sex hormone doesn’t affect prostate volume significantly apart from estradiol, and their contribution to severity of LUTS may have other mechanisms.


Article
Estimation of vitamin E level and its relation to lipid profile in patients with type II Diabetes Mellitus

Loading...
Loading...
Abstract

Background: Type 2 diabetes mellitus (T2DM) is considered a global disease as it affects over 150 million people worldwide, a number that is supposed to be doubled by 2025. High glucose levels, in vitro, appear to raise the extent of LDL oxidation, and glycated LDL is more prone to oxidative modification.Objective: To investigate the relationship between serum level of vitamin E and lipid profile in patients with type II DM.Methods: This study involved 28 patients suffering from type II DM diagnosed 1-4 years ago and with age ranged from 17 -60 years old, with different residence around Basra ; In addition to 56 apparently healthy persons matched in age and sex to the patients as a control group. The medical histories were taken and General examinations were done to them with measurement of their height and weight. Four milliliters of venous blood was drawn from each patient and control to measure TG, TC, VLDL, HDL, LDL, HbA1C and Vitamin E and the results were used to assess the presence of any association between Vit E levels and lipid profile.Results: The mean levels for patients and controls of TG were (157.1± 24.9 and 119.8 ± 29.0) mg/dl, of TC were (204.0 ± 43.2 and 168.0 ± 31.5) mg/dl, of VLDL was (31.5 ± 5.0 and 24.2 ± 5.9) mg/dl, of LDL was (129.6 ± 42.8 and 97.6 ± 30.8) mg/dl, of HDL was (42.9 ± 10.2 ± 46.0 ± 9.0) Mg /dl, of HbA1C were (9.4 ± 3.0 and 5.0 ± 0.7) % and of vitamin E were (3.7 ± 1.3 and 6.8 ± 2.0) mg/dl, respectively.There was a significant difference between all the above measured parameters, except of HDL, between cases and controls. Also there was a significant association between DM type II and low level of vitamin E. there was a significant negative correlations between vitamin E and TG, TC, LDL, VLDL but not HDL, even after adjustment for age, sex and BMI.Conclusion: Diabetes mellitus type II has a significant effect on vitamin E which is an important guard against dyslipidemias, one the major causes of diabetes vascular complications.

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

Arabic and English (1)

English (1)


Year
From To Submit

2015 (1)

2013 (1)