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Effect of Continuous Darkness on Immune Response (In vivo Assay)

Authors: Ikbal Kh. Al-Joofy (Ph.D.) Thana J. Al-Khishali (M.Sc.) --- Ikbal Kh. Al-Joofy (Ph.D.) Thana J. Al-Khishali (M.Sc.)
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 162-164
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Reports denote that changes in day length enhance or suppress components of immune function in several mammalian species. The aim of present experimental study is directed to test the hypothesis deals with the effect of photoperiods on some immune limbs responsiveness. Materials and Methods: Twenty six male and female BALB/C mice, 5-7 weeks old, 14-18gm weight divided into two groups, test groups (n.=8 mice for each sex) and control groups (n.=5 for each sex). Test groups were kept in a dark room for a month, while control groups were kept in a room where the photoperiod was day light: darkness 12:12hr. All studied groups immunized with o.2ml (10% sheep red blood cells) on day 4 and 8 of the last 12 days of the experiment. The weight of all animals were measured at the beginning and the end of the experiment. Arthus reaction, delayed type hypersensitivity and serum antibody titer were assessed on day 11 and 12 of program. J Fac Med Baghdad Vol. 49, No. 1, 2007 Received: May 2006 Accepted: Oct. 2006Results: Significant increased (P<0.005) in body weight, index level of Arthus reaction, delayed type hypersensitivity and serum antibody titer in the test groups in comparison with the control groups. Conclusion: Data are consistent with the hypothesis that immune parameters are enhanced in short photoperiods or continuous darkness. Keywords: Photoperiod, immune response

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