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ASSESSMENT OF SERUM ZINC LEVEL IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Author: Iqbal G. Farhood اقبال غالب فرهود
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2017 Volume: 15 Issue: 1 Pages: 39-47
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder affecting women of reproductive age characterized by multiple hormonal imbalances, reflecting on a clinical presentation dominated by manifestations of hyperandrogenism, which generate short and long term consequences on female health. Skin is a major target for androgen activity, several hyperandrogenemia-triggered dermatologic alterations can be seen in PCOS, most commonly hirsutism, androgenic alopecia, acne, seborrhea, onycholysis, and onychorrhexis. Zinc is one of the most important trace elements required as a catalytic, structural, and regulatory ion for the activities of more than 300 enzymes, proteins, and transcriptional factors. Zinc insufficiency in the female can lead to complications such as impaired synthesis/secretion of follicular stimulating hormone (FSH) and luteinizing hormone (LH), abnormal ovarian development.Objective:To assess serum zinc level in patients with PCOS.Methods:A case-controlled study was conducted in Al-Imamein Al-Kadhemein Medical City from the period of March to June 2016. Eighty females were enrolled in this study; their age ranged from 20 to 32 years. They were divided into 4 groups: Group I: Twenty patients with PCOS with body mass index (BMI) ranged from 30.0-40.0. Group II: Twenty normal healthy control obese ladies with BMI ranged from 30.0-40.0. Group III: Twenty patients with polycystic ovary syndrome with BMI ranged from 18.5-29.9. Group IV: Twenty females as a healthy control non-obese ladies with BMI ranged from 18.5-29.9.Results:Serum zinc level was significantly decreased in obese PCO group than in non-obese PCO group. Serum prolactin (PRL) level and LH levels were elevated in PCO group which was highly significant. There was negative correlation between serum zinc level and BMI in PCO patients. Also, negative correlation was observed between serum zinc level and serum PRL level in non-obese PCO patients.Conclusion:Serum zinc level reduced in obese PCOS than in non-obese PCO.Keywords: Serum zinc level, polycystic ovary syndrome


Article
RE-EVALUATION THE FREQUENCY OF CUTANEOUS MANIFESTATIONS IN PATIENTS ON HEMODIALYSIS

Authors: Zainab R. Naief زينب رائد نايف --- Iqbal G. Farhood اقبال غالب فرهود
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2013 Volume: 11 Issue: 4 Pages: 388-392
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Hemodialysis patients experience frequent and various cutaneous manifestations. Chronic renal failure (CRF) is a clinical state, which results in declining of kidney functions.Objective:To evaluate the frequency and nature of cutaneous lesions associated with CRF patients on hemodialysis.Methods:Fifty patients with chronic renal failure on hemodialysis in Al-Kadhimiya Teaching Hospital, Dialysis Center from the period of February 2012- May 2012 were conducted in this case series study.Results:All patients included in this study had at least one cutaneous manifestation related to chronic renal failure. The most frequent findings were pruritus (100%), pallor (100%), xerosis (100%), hyperpigmentation (74%), petechae (40%), ecchymosis (30%) and wrinkles (30%). Nail changes were half and half nail (76%), koilonychias (48%) and splinter hemorrhage (28%). Oral changes were xerostomia (88%) and ulceration (52%). Other manifestation like hair changes (42%) was seen.Conclusion:Chronic renal failure is associated with various cutaneous manifestations caused by hemodialysis or the disease itself. The most frequent findings; pruritus, pallor and xerosis. The early diagnosis of cutaneous changes may decrease the morbidity and eventually lead to the improvement of life quality in these patients.Keywords:Chronic renal failure, hemodialysis, cutaneous manifestations.


Article
2.ASSESSMENT OF SERUM ZINC LEVEL IN PATIENTS WITH ATOPIC DERMATITIS

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Abstract

Background:Atopic dermatitis (AD) is a common inflammatory skin disease with a chronic relapsed-remitting course with manifestations started at early childhood. AD is two types; extrinsic and intrinsic. Zinc has a crucial role in the immune system functions and antioxidant mechanisms, it also serves in the metabolism and cell growth through signaling several enzymes.Objective:To assess serum zinc level in patients with childhood AD.Methods:A case-controlled study was conducted in Dermatology outpatient’s clinic in Al-Imamein Al-Kadhimein Medical City, from the period of September 2016- June 2017. Twenty patients with AD were enrolled in this study. AD severity was graded using the Scoring Atopic Dermatitis Index (SCORAD). The control group consisted of age-matched and sex-matched twenty healthy children were taken with weight above 80%. Fasting blood samples were taken from patients and controls between 8 AM and 10 AM.Results:Of the twenty patients of AD, 13 (65%) were males and 7 (35%) were females. Their mean age was 4.58±3.13. Regarding the control group 9 (45%) were males and 11 (55%) were females, their mean age was 4.29±2.46. No statistical difference in serum zinc level between AD patients and control groups. Concerning zinc level in males and females, no statistical differences was found in AD patients, but highly significant difference was found in control group. Serum zinc level was highly significantly low in patients with moderate AD than in those with mild AD. There was negative correlation between serum zinc level and severity of AD.Conclusion:There is a negative correlation between serum zinc level and severity of AD, also there is a gender variation in serum zinc level in normal children.Keywords:Serum zinc level, atopic dermatitisCitation: Farhood IG, Ahmed MA, Al-Bandar RT, Farhood RG. Assessment of serum zinc level in patients with atopic dermatitis. Iraqi JMS. 2019; 17(2): 103-107. doi: 10.22578/IJMS.17.2.2

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