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Inhibitory Effects of Aqueous Extract of Garlic on Growth and Keratinase Activity of Trichophyton Mentagrophytes

Author: Israa M. Abd AL-Khaliq
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2011 Volume: 7 Issue: 2 Pages: 33-36
Publisher: Baghdad University جامعة بغداد


Background: The effect of garlic extracton fungal growth and keratinolytic activity was studied in Trichophytonmentagrophytes as one of the major etiologic agents of human and animal dermatophytosis in Baghdad and other parts of the World. Objective: To investigated an alternative antidermatophyte with minimum side effects which is plant based and biodegradable natural product Methods: Culture conditions for 30 isolates of T. mentagrophytes isolated from human dermatophytosis from both sexes with ages of 5-63 years in Central Medical city for the period July 2009 to October 2009 were cultured on specific solid medium. Results: The aqueous extract of garlic at various concentrations inhibited the growth of T. mentagrophytes. This inhibition reached to a maximum of 100٪ for extract at 10٪concentration. Keratinase synthesis was also inhibited by the extract about 91 ٪at 8 ٪ concentration. Conclusion: Fungal growth and keratinolytic activity are important factors in pathogenesis of the dermatophytes, their inhibition by garlic indicate that this substance may have potential values for treatment of human and animal dermatophytosis.

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