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The Role of Gabapentin in Prevention of Remifentanil-Induced Hyperalgesia

Author: Iyad Abbas Salman*, Bashar Zuhair Talib**
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2018 Volume: 17 Issue: 1 Pages: 1-5
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية


ABSTRACT:BACKGROUND: Remifentanil is widely used as intraoperative analgesic. Post infusion hyperalgesia has been documented experimentally in both animal and human volunteers. Gabapentin has anti-hyperalgesic effect.OBJECTIVE: To evaluate the effect of single preoperative oral dose of 300 mg gabapentin in attenuation of postoperative hyperalgesia induced by remifentanil and the decrease in post-operative analgesic requirement.PATIENT AND METHOD: A prospective randomized clinical trial conducted in Tikrit teaching hospital/ Iraq, at 2013. It involves 60 patients who underwent appendectomy. All patients were randomly allocated into two equql groups (each of 30 patients): First controlled group (CG) didn’t pre-medicated with gabapentine and 2nd gabapentine group (GG) pre-medicated with gabapentin. Intraoperative infusion of remifentanil was used & postoperative pain was assessed in all cases. RESULTS: The numerical analog scale NAS score and analgesia requirement post operatively was significantly higher in most times in the (CG) as compared with those of the (GG).CONCLUSION: Premedication with 300mg gabapentin orally decreased hyperalgesic effect induced by remifentanil and so decreased the pain score and the analgesic requirement postoperatively.

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