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Article
Immunophenotypic study of non-Hodgkin lymphomas in adult and elderly patients at National Center of Hematology-Baghdad.

Authors: Abdusalam Hatim Mohammed --- Sajid Saad Mohammed --- Jawad. k. Mashaali
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2014 Volume: 3 Issue: 2 Pages: 127-131
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Non-Hodgkin lymphomas (NHL) are a heterogeneous group of lymphoproliferativemalignancies with different patterns of behavior and responses to treatment. The understanding andhistopathological diagnosis of NHL has improved with the use of advanced technology. Theimmunophenotyping of tumors of hematopoietic origin serves in the first place to distinguish theseneoplasms from others, and to distinguish neoplasms from reactive processes.Objectives: The aim of this study was to determine the percent of each category of NHLPatients and Methods: Sixty eight patients who were diagnosed to have stage 4 non-Hodgkin lymphomaby histopathological examination of bone marrow aspirate and biopsy at National Center ofHematology/Baghdad were subjected to immunohistochemistry examination, two cases diagnosed ashairy cell leukemia by histopathological examination but not by immunohistochemistry as there were noCD markers available at the time of study so they were discarded from this study. Immunohistochemistrywas done either in hospital or in private laboratory for proper subtyping of the disease and yet to receivecorrect therapy and better response.Results: Cases were diagnosed as fallowsB-cell lymphoma constitute 57 cases 86.36%T-cell non-hodgkin lymphoma 6 cases 9.09%Splenic lymphoma 1 case 1.5%Mantle cell lymphoma 2 cases 3.03%Conclusion: Immunohistochemical study is a specific method to aid histopathology in proper diagnosisand subtyping of non-Hodgkin lymphoma


Article
Lipid Profile in Iraqi Children with ß-thalassemia Major

Authors: Jawad k.Mashaali --- Fatma A. Obed --- Noor Thair Tahir
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2014 Volume: 3 Issue: 2 Pages: 108-115
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

ABSTRACTBackground: Thalassemia are group of genetic disorders in which production of normalhemoglobin (Hb) is partly or completely suppressed because of defective synthesis of one ormore globin chains, vary from asymptomatic forms to severe or even fatal entities . Peoplewith thalassemia make less hemoglobin which results in mild or severe anemia presentas microcytic anemia. thalassemias are classified according to which chain of the hemoglobinmolecule is affected. In α thalassemias, α globin chain is affected, while in β thalassemia,production of the β globin chain is affected. Lipid abnormalities have been detected indifferent types of beta thalassemia, suggested mechanisms including plasma dilution due toanemia, accelerated erythropoiesis resulting in increased cholesterol uptake by macrophagesand histiocytes of the reticuloen-dothelial system, defective liver functioning due to ironoverload, macrophage system activation with cytokine release, and hormonal disturbances,Objectives: The purpose of the study was to examine the blood lipid profile in children withbeta-Thalassemia major in Iraq , and to determine the factors that affect it.Material and Method: Blood lipid profiles of forty-five patients between the ages of threeand ten years with beta-Thalassemia major who were receiving regular chelation therapyfollowed by from paediatric clinic of Ibn-albalady hospital were examined retrospectively.Blood lipid profiles of thirty healthy children were taken for use as the control group.Results: Hb and Hct values of the group with Beta-Thalassemia major were significantlylower than the control group . Ferritin values in the group with Beta-Thalassemia major werefound to be significantly higher than in the control group . Cholesterol, HDL-cholesterol,LDL-cholesterol levels were found to be significantly lower in patients with Beta-Thalassemia major than in the control group , while the triglyceride level was found to behigher .Conclusion: lower total cholesterol, LDL-HDLcholesterol and high TG was found in BTMgroups compared to healthy control participants. The suggested mechanisms for the decreasesin lipids are increased erythropoiesis and cholesterol consumption, iron overload, hormonalchange and oxidative stress in BTM.

Keywords

lipid --- thalassemia --- children


Article
Bacterial contamination in platelet concentrates versus single donor plateletpheresis

Authors: Nidal Karim Al-Rahal --- Fatma Abd Al Hamza --- Jawad K Mashaali
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2016 Volume: 29 Issue: 3 Pages: 173-177
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Transfusion of platelets is commonly indicated in patients with thrombocytopenia due to hematological or oncological diseases. These platelets are obtained either through apheresis from a single donor or derived from the whole blood of several donors. The risk of bacterial infections with platelet transfusions is increased due to platelet storage at 22 C̊ rather than the 4 C̊ required by red cells.Aim: to determine the prevalence of bacterial contamination in platelet units either of random platelet concentrates or single donor platelets and to establish a strategy to reduce the risk of platelet unit’s contamination to limit and eventually prevent transfusion of bacterially contaminated units.Material and Methods: This study was conducted in the National Center of Hematology Al-Mustaniriyah university during the period from 2nd of January till the end of May 2013 a total of 150 platelet donors, 100 random platelet concentrates derived from whole blood received from National Blood Bank in Baghdad of different donors &50 single donor platelets leukodepleted obtained from a single donor by apheresis using Haemonetics (MCS +) cell separator machine. Platelet bacterial contamination was studied by prospective (active) measure for five months. From all the 150 platelet units Gram stain &culture were done.Results: Positive Gram stain was observed in 13(13%) of random donor platelet samples,7 units of random donor platelet (7%) samples yield positive culture (true positive rate )and 6 units of random donor platelet (6%) yield negative culture results (false positive rate) .Microscopy stain was negative in 87 samples, of which 8(8%) yield positive culture (false negative rate) and 79(79%) produce negative Gram stain & culture. No positive Gram stain noticed in all 50 single donor platelet samples otherwise positive culture observed in one sample. The sensitivity of Gram stain was o.46%. Culture were positive 15(15%) of random donor platelets units and one (2%) of single donor platelets units with P- value 0.026. fourteen of random donor platelet units were found to be positive for bacterial growth, with coagulase-negative staphylococcus species 93.33%, plus one gram-negative rod (Klebsiella pneumonia) 6.67% .From the second group of 50 single donor platelet units, 1 of PLT units was found to be positive for bacterial growth, with coagulase-negative Staphylococcus species 100% . Conclusion: The use of single donor platelet s is a simple measure to reduce platelet unit’s contamination which is high in Iraq. Other measures will be required to eliminate all platelet units’ contamination

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