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Assessment Of Vascular And Lymphatic Vessels Density In Benign Vascular Lesions Using CD34 And D2-40 Immunohistochemical Markers

Authors: Jawaher M. Tater --- Bashar H. Abdullah
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2017 Volume: 29 Issue: 2 Pages: 61-64
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Vascular tumors and malformations, comprising a broad category of lesions often referred to asvascular anomalies. Hemangioma, represents a variety of vascular lesions (both malformations and tumor), whilelobular capillary hemangioma is a common vascular lesion of the skin and mucous membranes that occurs mainly inchildren and young adults. Lymphangiomas are malformations of the lymphatic system. At the level of lightmicroscopy the small lymphatics vessels may be similar to capillaries and sometimes are only tentatively identified bythe nature of their contents or by immunohistochemical staining procedure. This study aimed to assess the vascularand lymphatic vessels density in benign vascular lesions using CD34 and D2-40 immunohistochemical markers.Materials and Methods: Twenty two formalin-fixed paraffin-embedded tissue blocks of Hemangioma/vascularmalformation, thirty of lobular capillary hemangioma and another twenty of lymphangioma.Results: Lymphatic vessel density expressed by D2-40 immunomarker was found in all cases with mean (24.01±14.74)in lymphangioma ,for lobular capillary hemangioma it was (12.67±6.66) and for hemangioma was (9.77±6.82)where as the mean of microvessel density count measured by CD34 immunomarker was (49.87±31.97) for lobularcapillary hemangioma , in hemangioma it was (37.42±23.40) and (25.90±12.23 ) for lymphangioma.Conclusions: All vascular lesions are a mixture of blood and lymphatic vessels with different proportions,hemangioma shows high percentage of blood vessels and lymphangioma shows high percentage of lymphaticvessels.


Article
Immunohistochemical expression of endocan, as a marker of assessment of angiogenic potential in benign vascular lesions (hemangioma, lymphangioma and lobular capillary hemangioma) of head and neck region

Authors: Jawaher M.Tater --- Bashar H. Abdullah --- Wisam A.Hussain
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2018 Volume: 30 Issue: 4 Pages: 24-27
Publisher: Baghdad University جامعة بغداد

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Abstract

BACKGROUND: Vascular tumors are a heterogeneous group of diseases with biological behavior ranging from a hamartomatous growth to frank malignant. The pathophysiology of lymphangioma, vascular malformation and hemangioma is interconnected, blood vessels known to be the site of origin of hamartomas, venous malformations and some neoplasms as benign, tumor-like growth of vessels (hemangiomas). Angiogenesis is the process of formation of new blood vessels from an existing structure.Aims of study Assessment of angiogenic potential in benign vascular lesions (hemangioma, lymphangioma and lobular capillary hemangioma) of head and neck region.Materials and Methods: Twenty-two formalin-fixed paraffin-embedded tissue blocks of Hemangioma/vascular malformation, thirty of lobular capillary hemangioma and another twenty of lymphangioma to be stained with Endothelial cell-Specific Molecule-1 (ESM-1) monoclonal antibody.Results: Microvessel density expressed by Endothelial cell-Specific Molecule-1 (ESM-1) immunomarker was found in all cases with mean density of (37.44±23.16) for lobular capillary hemangioma and (25.02±13.89) for hemangioma and (6.34±3.52) for lymphangioma. According to post hoc test ESM-1 marker expression showed a high significant difference between (hemangioma and lymphangioma=0.001), (lymphangioma, pyogenic granuloma=0.000), and it was significantly different between (hemangioma, pyogenic granuloma=0.011)Conclusions: The obvious capillary growth in lobular capillary hemangioma revealed that lobular capillary hemangioma showed the highest activity of angiogenic potential in comparison to hemangioma and lymphangioma

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