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Article
HISTOLOGICAL STUDY ON THE STRUCTURAL CHANGES OF PLACENTA IN SMOKING IRAQI MOTHERS

Author: KHALIDA K JBARA
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2008 Volume: 14 Issue: 2 Pages: 18
Publisher: Basrah University جامعة البصرة

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Abstract

The placenta was chosen as a possible sample for detection of degenerative changes bytobacco smoking in the human pregnant female. Passive smoking mother during pregnancy isassociated with increase of collagen content of the villi, decrease fetal weight, increase in thenumber of villi, increase of trophoblastic apoptosis and increase in the thickness of maternofetalbarrier. Sections, 3-5 micron thickness of 40 full term placentae of passive smoking mothersand 30 number of gestational matched placenta were used as control, they were studiedunder light microscope. Appreciable degenerative changes were found in the group of passivesmoker females, he main findings were: thickening of the basement membrane of placentalvillus, increase in the collagen content of the villus, and increase in the syncytial budding,increase in the materno-fetal barrier thickness and extensive loss of trophoblast. This studyconcluded that tobacco is harmful to the human tissue and vascular system in generalsuggesting that smoking results in deteriorating organ structure and function.�

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Article
Stereological study of the mid piece of ductus epididymis In human and other animal species

Author: Khalida K. Jbara خالدةكاظم جبارة
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2012 Volume: 8 Issue: 13 Pages: 195-202
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

A stereological study of a (middle piece) of ductus epididymis between normal adult human, bulls, rams, goats and buffalos was conducted using routine histological techniques. The following stereological parameters were determined; Stereocilia height, epithelial height, muscular wall thickness, lumen and tube diameters. The human epididymal stereocilia height is shorter than in goat only and higher than bulls and goats in both the epithelial height and muscular wall thickness. Human ductile diameter is smaller than in other animals. In conclusion, all human epididymal mid piece parameters in the present study differ significantly than in the other animals. Because human epididymis differs from other animals in fine structure and luminal contents, the present stereological study shows how structural data obtained from histological micrographs of the intact tissue and cells can be different between human and other animals mid peiece ductus epididymis.

دراسة مصلية للجزء الوسطي لقناة البربخ مابين الانسان البالغ ,الثيران,الخرفان,الماعز,الجاموس حيث تمت باستخدام التقنيات النسيجية الاعتيادية.العوامل المصلية التي حدثت هي كالتالي : ارتفاع الخلايا النجمية الهدبية ,ارتفاع الخلايا الطلائية , سمك جدار العضلة ,قطر التجويف والانبوب البرزخي.كان ارتفاع الخلايا النجمية الهدبية في الانسان لقناة البربخ اقصر مما هو عليه في الماعز فقط واعلى بالمقارنة مع الثيران والماعز في كلا عاملي ارتفاع الخلايا الطلائية وسمك الجدار للعضلة اما قطر القناة في الانسان اصغر مقارنتا في الحيوانات الاخرى.استنتج من هذا ان كل العوامل المدروسة لهذا الجزء من البربخ في الانسان يختلف بصورة معنوية عن الحيوانات الاخرى بتركيبه الدقيق ومحتوى التجويف .الدراسة الحالية ايضا بينت كيفية الحصول على نتائج تركيبية من خلال القياسات الدقيقة النسيجية للانسجة والخلايا التي يمكن تمييزها عن الخلايا في الانسان او الحيوانات الاخرى لقناة البربخ.

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Article
HISTOLOGICAL AND STRUCTURAL STUDY OF PROLAPSED INTERVERTEBRAL DISC

Authors: Khalida K Jbara --- Thamer A Hamdan
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2006 Volume: 12 Issue: 1 Pages: 2
Publisher: Basrah University جامعة البصرة

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Abstract

The research of the etiology of low back pain and right leg pain has been focused on the study of histological degenerative changes of human intervertebral disc prolapse. In patients with low back pain & right leg pain and disc prolapsed according to magnetic resonance imaging (MRI), histological and histochemical studies have demonstrated several histological degenerative changes in the structure of the prolapsed intervertebral disc. Surgically excised intervertebral disc from 105 patients with lumber disc prolapsed were studied by histomorphology aided with histochemistry this include patients with prolapsed disc due to several causes. 5 control intervertebral discs were studied for comparison. Our result indicated that their was a degenerative structural changes of the intervertebral disc prolapse. Chondrocytes cloning, invasion of blood vessels into the disc matrix, disorganisation and disorientation of collagen fibers, matrix depletion and many other changes were observed.

Keywords

HISTOLOGICAL --- PROLAPSED --- INTERVERTEBRAL --- DISC


Article
Relationship of Granulated Metrial Gland cells to the trophoblastic barrier of mice and human placenta
العلاقة بين حبيبات خلايا غدة الأرومة الغاذية الرحمية لحاجز المشيمة للفئران والمشيمة البشرية

Author: Khalida K. Jbara, Hanaá Khazal Jaber
Journal: The Medical Journal of Basrah University المجلة الطبية لجامعة البصرة ISSN: 02530759 Year: 2013 Volume: 31 Issue: 2 Pages: 79-88
Publisher: Basrah University جامعة البصرة

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Abstract

Background: A study was performed on the presence of Granulated Metrial Gland (GMG) cells in mice uteri, similarly in human, the presence of human Decidual Granular Leukocytes (DGLs) in aborted placental samples was also studied. Aim of the study: to demonstrate further evidence which may lead to the suggestion that the granulated metrial gland (GMG) cells are specialized immune cells which are involved in inhibition of the rejection reaction of the mother to her foetus as an allograft in pregnant mice uterus and it's relation to the decidual granular leukocytes (DGLs) in human pregnant mothers during early pregnancy. Material and Method: Tissue samples of uterus were taken from mice on each of days (6, 10, 12, 14 and 16) of pregnancy, also human aborted placental tissue samples were taken at 2, 3 &5 months. All samples were prepared by using routine histological techniques.Results: Granulated cells were found in small numbers randomly distributed through out the endometrium on day 6 of pregnancy with a subsequent loss from areas of the antimesometrial and lateral decidua but increase dramatically in number in the developing decidua basalis sharing an intimate association with fibroblast-like stromal cells. Regarding human aborted placental tissue samples, similar to GMG cells, human Decidual Granular Leukocytes (DGLs) are the dominant cell population in 2 months aged deciduas, while in 3 and 5 months aged placenta, the placenta appeared with reduced populations and distribution of DGLs, they looked unhealthy. The loss of (GMG) cells from the implantation sites is accounted for either by degeneration in situ or by migration via vascular channels to the blood vessels of maternal placenta which suggested that it could be of functional significance. Conclusion: Our results indicate that DGLs probably protect the materno-foetal unit from other effects causing disorders to the placental development, and it may play a role in the pathogenesis of idiopathic repetitive abortion.

المقدمة: دراسة أجريت على ألخلايا ألحبيبيه لغدة ألمتريال لأنثى ألفأر ألحامل في ألأيام 6و10و12و14 و16 من ألحمل, وكذلك أجريت دراسة مماثله للخلايا ألحبيبيه ألبيضاء للساقط ألقاعدي و لمشيمة ألنساء ألحوامل في ألأشهر 2و 3و5 بعد الأجهاض.المواد وطرق العمل : تم أخذ عينات الأنسجة من الرحم من الفئران في كل أيام (6،10،12،14 و 16) من الحمل، اتخذت إحباط عينات أنسجة المشيمة البشرية أيضا في 2،3 و 5 أشهر أعدت جميع العينات وباستخدام التقنيات النسيجية الروتينية. ألنتائج: بينت ألدراسة بأن عدد قليل من ألخلايا ألحبيبية ظهرت في رحم أنثى ألفأر ألحامل في أليوم ألسادس من ألحمل وبدأت بزيادة ملحوضة مع تطور ألساقط ألقاعدي، وأظهرت علاقة متينة مع ألخلايا المكونة للألياف. أما بالنسبة الى ألخلايا ألحبيبية ألبيضاء لمشيمة ألنساء ألحوامل ألمشابهة للخلايا ألحبيبيه لغدة ألمتريال لأنثى ألفأر ألحامل، وجدت هذه ألخلايا بشكل سائد في ألمشيمة للشهر ألثاني من ألحمل. بينما أخذ ألعدد بالتناقص في ألشهر ألثالث والخامس بعد الإجهاض وكذلك ظهرت ألمشيمة متخلفة صحيا.ألمناقشة: فقدان ألخلايا وقلتها من مكان تطورها في غده ألمتريال في رحم أنثى ألفأر الحامل أثناء فترة ألحمل ربما يرجع ألى هجرة هذه ألخلايا بواسطة ألأوعية ألدمويه خاصة وأنها شوهدت في هّذه بعض ألأوعية ألمتصلة بالمشيمة أذ ربما تقوم بعمل وظيفي معين في ألمشيمة خاصة وان ألمِشيمة هي ألرابط ألرئيسي بين ألأم والجنين، ربما يكون هذا ألعمل هو حماية لأنسجه ألأم والجنين من أي تفاعلات مضادة.ألخلفيه: دراسة أجريت على ألخلايا ألحبيبية لغدة ألمتريال لأنثى ألفأر ألحامل في ألأيام 6و10و12و14 و16 من ألحمل، وكذلك أجريت دراسة مماثله للخلايا ألحبيبيه ألبيضاء للساقط ألقاعدي و لمشيمة ألنساء ألحوامل في ألأشهر 2و 3و5 بعد الإجهاض.هدف ألدراسة: الهدف من هذه الدراسة هو إظهار أي أدلة أخرى مما قد يؤدي إلى القول بأن خلايا الغدة الرحمية المحببة (GMG) هي الخلايا المناعية المتخصصة التي تشارك في تثبيط رد فعل الرفض من الأم إلى جنينها بمثابة طعم خيفي في رحم الفئران الحوامل و كذلك متابعة هذه ألخلايا في ألمشيمة ألبشرية لغرض أثبات بأنها تقوم بنفس ألعمل والوظيفة آلتي تؤديها في مشيمة ألفئران وعلاقتها بخلايا الكريات البيض ساقطي الحبيبية (DGLS) في الأمهات الحوامل في الإنسان أثناء الحمل المبكر. ألاستنتاجات: الخلايا القاتلة الطبيعية (NK) هي نوع من خلايا الجهاز المناعي التي تحتوي على حبيبات مع المواد الكيميائية وهي ربما تكون القامع الطبيعي لحماية ألتفاعل بين انسجه ألأم و الجنين من الآثار الأخرى التي تسبب اضطرابات في تنمية المشيمة. وقد تجلى النشاط المثبط للمناعة في الأشهر الثلاثة الأولى من ألحمل في مشيمة ألنساء الحوامل في الإنسان والتي من الممكن أن تلعب دورا في الوقاية من هجوم مناعي خيفي من قبل ألأمهات على الجنين وبالتالي منع الإجهاض العفوي. البحوث التي أجريت مؤخرا تسلط الضوء على حقيقة أن الخلايا القاتلة الطبيعية قد يكون بمثابة خلية قامعة و هي أيضا خلايا تنظيمية تعمل في التفاعلات المتبادلة مع الخلايا الجذعية، الضامة، وخلايا T والخلايا البطانية.


Article
HISTOLOGICAL DEMONSTRATION OF PAINFUL PROLAPSED INTERVERTEBRAL DISC WITH HISTOCHEMICAL DETECTION OF NERVES INGROWTH

Authors: Eman A Hashimra� --- Khalida K Jbara� --- Thamer A Hamdan�
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2007 Volume: 13 Issue: 1 Pages: 1-5
Publisher: Basrah University جامعة البصرة

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Abstract

Microscopic study was done on surgically collected samples of prolapsed intervertebral disc. These samples were collected from patients suffered from low back pain associated with right or left leg pain. The study was focused on patients below 40 years. Magnetic resonance imaging (MRI) was used to confirm the diagnosis.The study demonstrates the degenerative changes that occur early in these patients which may be resulted from any traumatic causes which lead to series of degenerative changes that occur faster and differ from that changes which occur with age progress.Forty samples of prolapsed intervertebral discs were collected surgically and 5 control intervertebral disc were studied for comparison.Nerve ingrowths have demonstrated (histological and histochemical) in region of the excised tissue of prolapsed disc. This feature is accompanied with several degenerative changes like cloning of chondrocytes, irregularity of collagen fibers, and invasion of newly formed blood vessels into the disc matrix.

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Article
HISTOLOGICAL CHANGES OF LIGAMENTA FLAVA IN ‎LUMBAR DISC HERNIATION AND SPINAL CANAL ‎STENOSIS

Authors: Hatem A Hatem --- Khalida K Jbara --- Thamer A Hamdan
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2005 Volume: 11 Issue: 2 Pages: 24-37
Publisher: Basrah University جامعة البصرة

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Abstract

‏ ‏Samples of ligamenta flava were obtained after surgical operations from 50 patients with a ‎lumbar disc herniation, another 50 patients with a lumbar canal stenosis, and 25 patients with ‎spinal fractures who were used as control group. ‎‎ Ligamenta flava from control patients aged below 46 years consisted of large elastic fibers, ‎thin bundles of collagen fibers, and few spindle-shaped fibroblast cells.‎In close proximity to the laminal insertion, the ligamentum flavum had fibrocartilagineous ‎features. in the control patients who were aged 46 or older, the areas that had fewer and thinner ‎elastic fibers and a more abundant collagen component were visible occasionally. The spindle-‎shaped fibroblast cells were fewer compared with control patients aged below 46 years. Also ‎remnants of necrotic cells and few, short, thin, interwoven, fragmented, non-branching elastic ‎fibers, as well as small calcified areas, were occasionally visible. ‎‎ In close proximity to the laminal insertion, the ligamentum flavum had larger fibrocartilaginous ‎features with more collagen fibers compared with younger patients. ‎‎ In patients with disc herniation, the ligamenta flava had nearly similar morphologic features to ‎those of the control patients of similar ages. The ligamenta flava from patients with lumbar ‎spinal stenosis aged below 46 years showed areas of fibrosis in which the cells were often ‎represented by fibroblast cells and in stenotic patients older than 46 years, central portion of ‎ligamentum flavum showed areas of fibrosis, in which the elastic fibers appear normal in some ‎areas, showed little changes in others and in most of these areas showed great changes. ‎Fibrous septa, degenerating elastic fibers as well as small calcified areas were observed often.‎‎ In conclusion, Lumbar ligamentum flavum as any tissue in human body undergo degenerative ‎changes during aging. In lumbar canal stenosis, the degenerative changes were more obvious ‎compared with normal spine or lumbar disc herniation. In stenotic patients, ligamenta flava ‎show a significant decrease in the elastic component as a result of fibrosis and chondroid ‎metaplasia of the tissue, as well as degeneration of the elastic fibers. These changes, and the ‎presence of calcified areas within the tissue, decrease the elasticity of the ligaments. An elastic ‎tissue can be deformed under traction and gradually return to its normal size, proportional to ‎the decrease of the elastic tension. Ligamenta flava do not normally bulge into the spinal canal ‎when spine is in the neutral position.‎

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