research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Histopathological evaluation of bone healing using Nanobone in experimentally induced frontal bone defects of rabbits

Authors: Alaa S. Jaber علاء جبار --- Kadhim A. Al-Soudani كاظم السوداني
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 4 Pages: 40-45
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: The bone substitute biomaterials are used in reconstruction of bone defects and one of them isNanobone. It consists of nanocrystalline hydroxyapatite embedded in a highly porous matrix of silica gel. It promotesthe healing of bone defects and increases the amount of new bone formed. It is degraded and resorbed byosteoclasts after a period of time. The aim of study was to evaluate the effects of Nanobone on bone healing inexperimentally frontal bony defects of rabbits.Materials & Methods: Thirty five indigenous rabbits were used in this study. Granules of Nanobone were implanted insurgically induced defects of 5mm size in one side in the frontal bone of rabbits, while the other side defects were leftfree to heal spontaneously as controls. Samples were taken after 2, 6, 9, 12 and 24 weeks and demineralized. Theamount of new bone formed around implanted granules and the inflammation present were analyzed by means oflight microscopy in both Nanobone granules-filled defects and controls.Results: At 2 weeks, there was no new bone formed in both defects with few amount of inflammation whichconsiders normal at this time. At 6, 9 and 12 weeks , the amount of new bone formed in Nanobone filled defects wasmuch more than that formed in controls (statistically significant correlation, P<0.05), no inflammation seen in boths. At24 weeks, the Nanobone granules were degraded and completely replaced by new bone while in controls therewas few spaces not filled with bone (statistically highly significant correlation, P<0.01), no inflammation seen also.Conclusions: Results of present study revealed that Nanobone material promotes healing of bony defects incomparison to controls and is degraded and replaced by new bone after a period of time


Article
Histopathological evaluation of aragonitic calcium carbonate as a bone graft substitute in rabbit's mandible (An experimental study)

Authors: Samir W. Abrahem سامر ابراهيم --- Kadhim A. Al-Soudani كاظم السوداني
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 4 Pages: 58-61
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Augmentation of the craniomaxillofacial region is required for many aesthetic and reconstructiveprocedures. Many bone grafts substitutes have been developed .These products differ in their osteoconductive andosteoinductive properties .The use of bone graft substitutes offers the ability to lessen the possible morbidity of theharvest site inautograft. Aragonitic calcium carbonate has proved to have biocompatible properties as bone graftsubstitute. This study aimed to evaluate the histopathological effects of aragonitic calcium carbonate inexperimentally induced bone defect in rabbit's mandible.Material & method: Twenty five adult male healthy rabbits were used in current study. Two holes were prepared inthe rabbit's mandible, first hole remain empty as control, the second filled with aragonitic calcium carbonate.Samples were taken after 2, 6,8,12 and 24 weeks. Histopathological evaluation include; examination of new boneformation and inflammatory response, in both control and experimental groups.Results: At 2 weeks, there was no new bone formation in both defects with moderate amount of inflammation .At6,12 and 24 weeks the amount of new bone formation in implant group was more than that formed in control group( statistically highly significant correlation, p<0.01). At 8 weeks, less bone amount in implant group .There weremarked degradation of implant particles at 6 weeks.Conclusions: ACC is suitable bone graft substitute and induce new bone formation by acting as bioactive,osteoconductive bone graft when come in contact with bone.

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2012 (2)