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A Comparative Study of Immunohistochemical Expression of Moesin, Cytokeratin 14 andMMP7 in Oral Squamous Cell Carcinoma and Oral Verrucous Carcinoma

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Abstract

Background: Squamous cell carcinoma (SCC) is the most prevalent malignant neoplasm of the oral cavity thatexhibits certain histological variations. Verrucous carcinoma (VC) is an uncommon exophytic low-grade welldifferentiatedvariant of SCC. Cellular differentiation and morphology play important roles in cell functions andmaintenance of structural integrity .As the cancer is a malignant process in which disorder of the cell growth andbehavior occurs, such changes may differ in different tumor types and within different grades of the same tumor.Materials and Methods:Forty two formalin – fixed, paraffin – embedded tissue blocks were included in this study (30blocks were diagnosed as OSCC and 12 blocks were diagnosed as OVC). An immunohistochemical staining wasperformed using anti moesin, anti CK14 and anti MMP7 monoclonal antibodies.Results: Moesinimmunoreactivity was recognized in all the studied groups with predominant cytoplasmic expressionin OSCC & membranous expression in OVC. No difference was noticed between 2 studied groups &betweendifferent grades of OSCC. Cytokeratin 14 positivity was noticed in all studied groups with significant differencebetween OSCC&OVC (p=0.012) & there was a significant difference between the different grade of OSCC(p=0.047). MMP7 expression was observed in the all studied groups with predominant cytoplasmic pattern in OSCC &nuclear pattern in OVC. No difference was found between the 2studied groups &between the different grades ofSCC. A Strong positive linear correlation between MMP7&CK14 was noticed.Conclusion: Verrucous carcinoma has a specific pattern for moesin and MMP7 that differs from OSCC, however; thedifference is not significant. CK14 immunoreactivity indicated a significant difference in the degree of cellulardifferentiation between OSCC &OVC

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