research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
QT interval analysis in type 2 diabetic patients

Author: Kawthar H. Msayer
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 4 Pages: 462-467
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Summary:-Background: The electrocardiographic QT interval has been extensively studied in diabetes mellitus. Recently, there has been increasing interest in the relationship between diabetes and QT abnormalities .The QT interval, which is easily obtained from a standard resting electrocardiogram( ECG), reflected the total duration of ventricular myocardial depolarization and repolarization. The heart rate corrected QT interval (QTc) by Bazett's formula on the electrocardiogram has been proposed as a risk factor for ventricular arrhythmias in diabetes mellitus. Dispersion of QT(QTd) is defined as the difference between maximum and minimum QT interval QT interval on 12 lead ECG, which reflected spatial ventricular repolarization in homogeneity ,has been report to increase in diabetic subjects compare with non diabetic subjects. Patients and Methods: Type 2 diabetic patients (n=80) and healthy subjects (n=25) were required to have 12-lead ECG suitable for QT analysis ,QT interval was measured in each lead to found(maximum, minimum, and mean ).QT interval vary according to the heart rate, it can be corrected using Bazett's formula to give QTc interval, and to found (maximum, minimum, and mean).Dispersion of QT interval(QTd) was calculate using the difference between the maximum and minimum QT interval duration as same as for dispersion of corrected QT interval(QTcd). Result: There were significant difference in QT interval indices between type 2 diabetic and healthy subjects (P<0.05) as well as the correct QT interval indices. ROC curve analysis of QT and QTc interval duration parameters demonstrated that no QT parameters performs better than maximum and minimum of QT and QTc, areas under ROC curve were(0.69 and 0.66 P<0.001)for maximum and mean QT respectively and (0.80 and 0.75 P<0.001) for maximum and mean QTc respectively. From this result we can say that QTc parameters better than QT parameters in context of patients and control differences. In multiple linear regression models, maximum, mean, and dispersion of QT interval were significantly affect by diabetes mellitus after adjustment for age, gender, body mass index (BMI), and heart rate. Whereas, only maximum and mean QTc were significantly affected by diabetes mellitus after adjustment for age, gender, and BMI. Prolongation of QT interval (QTc and QTd) also seen in a diabetic subjects which significant different as compare to the healthy subjects. Conclusion: The result of this study indicate that corrected QT interval (maximum and mean)in a routine ECG is a useful marker to identify the QT abnormalities differentiating diabetes type 2 from healthy subjects.


Article
HEMODYNAMIC FACTORS DETERMINING IMMEDIATE RESPONSE OF LEFT ATRIAL PRESSURE REDUCTION ATTRIBUTED TO BALLOON MITRAL VALVOTOMY

Authors: Mawada Mousa Funjan --- Kawthar H. Msayer --- Zaid Mohammed Taha
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2010 Volume: 13 Issue: 3 Pages: 88-98
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

Rheumatic mitral stenosis is a chronic cardiac disease that results in considerable anatomicaland functional alternations. Mitral stenosis (MS) is associated with elevated left atrial pressure(LAP). Balloon Mitral Valvuloplasty (BMV) is a proven modality in the treatment of mitral valvestenosis. The purpose of this study was to assess the success of balloon mitral Valvotomy via themeasurements of LAP and PAP before and after procedures and to determine the hemodynamicfactors that may influence reduction in mean LAP in patients with adequate relief of mitral valveobstruction after BMV.Twenty seven patients with moderate to severe mitral stenosis underwent cardiaccatheterization. Hemodynamic measurements were recorded at pre-valvuloplasty and after balloonvalvuloplasty. All patients were submitted to an echocardiography before BMV and the test wasperformed after the procedure to measure the mitral valve area. The results presented in this studywere based on analysis of changes in mean left atrial pressure (LAP) attributed to BMV procedurequartiles in a sample of 27 patients with MS. The study subjects were categorized into orderedcategories based on resulting quartiles of LAP change. The group with highest change includedthose in whom LAP was ( 18) mmHg after BMV, the second group with average responseincluded those in whom LAP was (17) to (7) mmHg after BMV, and third group with lowestresponse included those in whom LAP was ( 6) mmHg after BMV. The changes in mean LAPattributed to procedure showed a statistically significant linear correlation with mean (LAP) beforeBMV (r  0.712, p<0.001), and mean pulmonary artery pressure (PAP) before BMV had astatistically significant linear correlation with changes in mean LAP attributed to procedure(r  0.68, p < 0.001). By using receiver operator characteristic curve (ROC) can distinguish thebest homodynamic measurements before BMV that can be efficiently determine change in meanLAP attribute to BMV procedure. The (mean LAP and mean PAP) before the procedure (pretreatment)are an important contributing factors for determine the reduction in mean LAP attributedto BMV procedure.

تضيق الصمام الإكليلي الروماتيزمي هو احدأمراض القلب المزمنة التي تنتج عنها تغيير تشريحي ووضيفي للصمام الإكليلي، وتضييق هذا الصمام يؤديإلى ارتفاع ضغط الأذين الأيسر وأحدى طرقعلاج تضيق الصمام الإكليلي هي توسيع الصمامباستخدام البالون في عملية القسطرة القلبيةيرتكز البحث [Balloon Mitral Valvatomy (BMV)]على مدى نجاح عملية توسيع الصمام الاكليلي من خلالقياس ضغط الأذين الايسر قبل وبعد العملية و تحديدالعوامل الهيمودايناميكية التي قد تؤثر في انخفاض ضغطالأذين الأيسر لمرضى تضيق الصمام الإكليلي بعد إجراء.(BMV) عملية توسيع الصمام الإكليليشملت الدراسة 27 مريضا عانوا من تضيق الصمامالاكليلي، خضعوا لعملية القسطرة القلبية حيث تتراوح شدة(moderate to sever) المرض بين المتوسط الى الشديدوتم اخذ القياسات الهيموديناميكية لكل مريض قبل وبعدكما تم استخدام تصوير .(BMV) عملية توسيع الصمام(2-D echocardiograph) القلب الصدوي ثنائي البعدوذلك (BMV) لجميع المرضى قبل وبعد توسيع الصماملقياس مساحة الصمام الإكليلي.النتائج المقدمة في هذه الدراسة هي حول تحليل التغيرالحاصل في ضغط الأذين الأيسر بعد عملية توسيع الصمام،تم تقسيم المرضى الى ثلاثة مجاميع اعتمادأ على مقدارالانخفاض الآني في ضغط الاذين الايسر او الاستجابهلعملية التوسيع. المجموعه الاولى هي المجموعه الاكثراستجابه او الاكثر انخفاض في ضغط الاذين الأيسر حيثكان ضغط الأذين الأيسر لديهم (اقل أويساوي 18 ملمزئبق)، والمجموعة الثانية ذات الانخفاض المتوسط، حيثكان ضغط الذين الأيسر لديهم من [( 17 ) إلى ( 7) ملمزئبق] والمجموعة الثالثة التي أظهرت اقل استجابةوانخفاض في ضغط الاذين الأيسر حيث كان ضغط الذينالأيسر لديهم (اكبر أو يساوي 6 ملم زئبق) بعد عمليةتوسيع الصمام.هذه الدراسة بينت ان معدل التغير في ضغط الاذينالايسر نتيجة لعملية توسيع الصمام يرتبط ارتباط قوي معضغطي الشريان الرئوي والاذين الايسر قبل التوسيع. وحيث إن العوامل المشمولة بالدراسة (ضغط الاذين الايسروالشريان الرئوي) هي عوامل وثيقة الصلة ببعضهاالبعض.للتمييز (ROC curve) تم استخدام التحليل الاحصائيبين اي عامل من العوامل المقاسة قبل توسيع الصمام يكونالاكثر ارتباطا بانخفاظ ضغط الاذين الايسر بعد التوسيع منخلال معرفة المساحة تحت المنحني لكل عامل من العواملالمذكورة انفا. حيث تبين من خلال هذه الاجراءاتالاحصائيه ان قيمة ضغط الشريان الرئوي قبل اجراء عمليةالتوسيع هما من العوامل الاساسيه في تحديد مدى الاستجابةاوالانخفاض في ضغط الاذين الايسر بعد اجراء عملية.(BMV) توسيع الصمام الاكليلي

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2010 (2)