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The Role of Garlic Extract on the Effect of Organic Pesticides on Murine Liver Cells

Author: Khalid Hamdan Gathwn
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 3 Pages: 344-350
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACK GROUND:Organic phosphorus pesticides are most widely preferred pesticides, and know to have detrimental effect on various living organisms.METHODS:Twenty four male Balb/c mice were used. These were divided into four group (1,2,3,4) . Chlorpyriphos was given orally on alternate days by garage (20mg/kg body weight), aqueous garlic alone was given orally daily by garage (200mg/kg body weight, while garlic extract followed by chlorphriphos was also given.RESULTS:Lipid peroxidation (LPO) was measured in liver homogenate . The extent of LPO was significantly increased in animals treated with pesticide while non-significant result were obtained with garlic extract alone . Pretreatment with garlic followed by pesticide showed similar values. The levels of glutathione and total thiol was significantly decreased in animals treated with pesticide and non- significant with garlic . pretreatment with garlic followed by pesticide showed similar value. The free radical scavenging enzyme like SOD , as well as GSH- dependent enzyme (GPx, GST and GR) show significant decrease in animals treated with pesticide and non-significant with garlic. Pretreatment with garlic followed by pesticide showed similar to that of control.CONCLUSION:Pesticide exposure could be prevented by Co-administration of garlic extract.

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