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Article
Thyroid Auto-antibodies in Goitrous Euthyroid Patients in Iraq
الأجسام المضادة ذاتية المنشأ لدى المرضى العراقيين المصابين بتضخم الغدة الدرقية ذات الافراز الطبيعي

Author: Khalid Ibrahim AL-Lehibi خالد ابراهيم اللهيبي
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2007 Volume: 12 Issue: 1 Pages: 90-95
Publisher: Tikrit University جامعة تكريت

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Abstract

Thyroid auto-antibodies, especially anti-thyroglobulin antibodies (TgAb) and anti-thyroperoxidase antibodies (TPO) are present in positive titers in over 90% of auto-immune thyroiditis, but they are also present in positive titers in about 10-20% of the general population and females outnumber males.Among the 112 patients with goiter, 99 were females (88.39%) and 13 were males (11.60%), with most of patients fall in the age range of 26-46years (60.68%). Fine needle aspiration biopsy (F.N.A.) which was performed on 39 patients showed a colloid goiter in 79.48% of them..Out of those 112 patients, 42 (37.5%) have a positive thyroid auto-antibody titer, while the other 70 (62.5%) have either a borderline or a negative titer ( p-value< 0.05).Among the positive 42 (37.5%) patients, most of cases (64.2%) fall in the age range between 26-45, with female predominance (90.47% for females and 9.52% for males).Mean titer of anti-thyroglobulin antibodies (anti-TgAb) was 577.88 i.u./mL and that for anti-thyroperoxidase antibodies (anti-TPOAb) was 203.21 i.u./ml ( p-value < 0.001) . Among the normal 80 persons, 70 (87.5%) were females, and 10 (12.5%) were males. The auto-antibody test was positive in 18 persons (22.5%), 17 females and 1 male only.Key words: Anti-thyroglobulin auto-antibodies (TgAb), anti-thyroperoxidase auto-antibodies (TPOAb), auto-immune thyroid disease (AITD).

ان الاجسام المضادة للدرقية ذاتية المنشأ وخاصة المضادة لـ Thyroglobulin وتلك المضادة لـ ((ثايروبيروكسيديز)) موجودة بمستويات عالية لدى اكثر من 90% من المصابين بالتهاب الغدة الدرقية المناعي ذاتي المنشأ، لكن هذه الاجسام موجودة ايضا بمستويات عالية عند حوالي (10-20%) من عامة الناس وخاصة لدى النساء.من مجموع 112 مريضا كان عدد الاناث 99 (88.39%) وعدد الذكور 13 (11.60%) ومعظم المرضى تتراوح اعمارهم بين 26-45 سنة (60.68%)،ان خزعة الدرقية التي تم انجازها على 39 مريضا اظهرت ان 79.48% منهم كان لديهم تضخم الدرقية الغرواني colloid goitreمن مجموع 112 مريضا تحت الدراسة كان 42 منهم (37.5%) لديهم مستويات عالية من الاجسام المضادة للدرقية ذاتية المنشأ في حين ان الباقي وهم 70 مريضا (62.5%) كانت مستويات الاجسام المضادة لديهم سالبة او ذات مستويات واطئة (p<0.05) .ان المرضى الذين لديهم مستويات عالية من الاجسام المضادة وعددهم 42 (37.5%) تتراوح اعمار معظمهم بين 26-45 سنة واكثرهم من الاناث (890.4% اناث ، 9.52% ذكور).ان متوسط مستوى الاجسام المضادة ل Thyroglobulin كان 577.88 وحدة عالمية لكل ملي لتر من الدم في حين كان 203.21 وحدة لكل ملي لتر بالنسبة للاجسام المضادة ل Thyroperoxidase (p<0.001) . ضمن مجموعة السيطرة البالغ عددهم ثمانين (80) كان اكثرهم من الاناث (70 انثى 87.5%) في حين كان عدد الذكور عشرة (10 ذكور 12.5%) .كانت مستويات الاجسام المضادة مرتفعة لدى 18 شخصا (22.5%) بضمنها 17 انثى وذكر واحد.

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Article
The Role of Metformin in patients with Primary Hypothyroidism

Authors: ,Anmar Alharganee *** --- ,Marwah Isam Abdulrahman **, --- Khalid Ibrahim Al-Lehibi* ,
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2019 Volume: 15 Issue: 1 Pages: 79-85
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Insulin resistance is present in 50% or more of patients with primary hypothyroidism. Metformin can decrease TSH levels in these patients by a complex matter, this can be of great help in clinical practice.Objective: This study was designed to evaluate the effect of metformin in reducing TSH levels in patients with primary hypothyroidism.Methods: Hundred patients with primary hypothyroidism, 82 females, 18 males were included in this study, everyone was followed up for two months after adding metformin 850 mg twice daily in addition to thyroxin.Results: 36 patients (36%) have a normal baseline TSH and no change after 2 months, 64 patients (64%)have a change in TSH either a decrease(49 patients ,79.56%) or an increase (15 patients , 23.44 % ).Conclusion: Metformin therapy is highly effective in reducing TSH levels in patients with primary hypothyroidism


Article
The Necessity of Teaching Diabetic Patients the

Author: *Khalid Ibrahim Al- Lehibi FRCP (Edin),**Yousif Abdul Raheem FICMS/CM ***Ibtisam Shilbah Hussein
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 1 Pages: 136-144
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: It is important to achieve good glycemic control to avoid long-term diabetic complications. It has been largely debated about the role of correct way of insulin administration to get the desired glycemic control.Objective: To evaluate the effect of teaching diabetic patients who are on insulin therapy the correct way of injecting insulin and its effect on glycemic control.Methods: A non randomized clinical trial with 820 diabetic patients on insulin therapy on whom A1 c estimation was performed before and after three months of teaching them the right injection technique.Results : Sixty seven patients (8.17%) had A1 c 6.5% before they were enrolled in the study while the majority (753 patents, 91.82%) had A1 c 6.5% and the last group showed the best benefit of teaching them the correct way of injection when compared with first group (P= 0.0001). Also patient with age 20-40years showed the best results (P=0.0001), while the poorest results were observed in those aged 40 years and above.Conclusion: Teaching patients the right injection technique is important to achieve good glycemic control in those who already had poor one.Keywords: glycemic control, A1 c, injection technique.


Article
The Necessity of Teaching Diabetic Patients the Correct way of Insulin Administration: A Clinical Trial to Improve Glycemic Control

Author: *Khalid Ibrahim Al- Lehibi FRCP (Edin),**Yousif Abdul Raheem FICMS/CM ***Ibtisam Shilbah Hussein
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 2 Pages: 137-146
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: It is important to achieve good glycemic control to avoid long-term diabetic complications. It has been largely debated about the role of correct way of insulin administration to get the desired glycemic control.Objective: To evaluate the effect of teaching diabetic patients who are on insulin therapy the correct way of injecting insulin and its effect on glycemic control.Methods: A non randomized clinical trial with 820 diabetic patients on insulin therapy on whom A1 c estimation was performed before and after three months of teaching them the right injection technique.Results : Sixty seven patients (8.17%) had A1 c 6.5% before they were enrolled in the study while the majority (753 patents, 91.82%) had A1 c 6.5% and the last group showed the best benefit of teaching them the correct way of injection when compared with first group (P= 0.0001). Also patient with age 20-40years showed the best results (P=0.0001), while the poorest results were observed in those aged 40 years and above. Conclusion: Teaching patients the right injection technique is important to achieve good glycemic control in those who already had poor one. Keywords: glycemic control, A1 c, injection technique.


Article
Prevalence Some Pathogenic Bacteria Causing UTI in Diabetic Patients In / Specialized Center For Endocrinology and Diabetes of Baghdad City–Iraq

Authors: Nihad Khalawe Tektook --- Khalid Ibrahim Al- Lehibi --- Raad K. Al-Husseinei
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 2 Pages: 260 -266
Publisher: Babylon University جامعة بابل

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Abstract

Urinary tract infections (UTIs) are caused by microorganisms but Bacteria are the most common cause when they overcome the natural defenses and causing infection, especially in patients with diabetes mellitus and its may present as asymptomatic bacteriuria, leading more serious infections. The aim of this study was to assess the prevalence of bacteria causing UTIs among diabetic patients. Collected one hundred and seventy five samples of sera and urine form diabetic patients with & without UTIs were studied from the specialized center for Endocrinology and diabetes All urine samples were tested by General urine examination (G.U.E) in addition to urine culture. On MacConkey and blood agar then identify the presence of the bacteria.Urinary tract infection increased with aging and increase percentage of UTI among individuals above 40 years so, high incidence of UTI among diabetic females (75%) rather that in diabetic males (25%). prominent UTI among females (68.8%) rather than males (31.1%) either diabetic or non-diabetic patients, as well as prevalence of smoking among males (74 %) than females (26%), So, Escherichia coli (15 isolates) most of them (13 isolates) in the urine sample of type II D.M particulary, the elderly ≥40 years females (11 isolates), and conclude from this study the duration of diabetes can affect the development of complication especially UTI complications, where their prevalence increases with longer duration of disease,Women with diabetes have more frequent and more sever UTI, and Escherichia.coli was the most common pathogen isolated in both groups.


Article
Metabolic syndrome in women with polycystic ovary syndrome

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Abstract

Objectives: To report the Cesarean section rate in Al-Batool Maternity Teaching Hospital and to identifyhow many of them were done for maternal and fetalcondition.Design: A statistical cross sectional study.Setting: The study was conducted at Al-BatoolMaternity Teaching Hospital (13000 deliveries peryear).Participants: The patients group consists of 4556patients admitted for delivery (vaginal and abdominal)during a period of four months commencing fromJanuary 2003.Main outcome measures: calculation of all livebirths, calculation of cesarean section rate, percentageof the primary cesarean sections and the repeatcesarean sections and listing the indications of theoperation according to maternal and fetal conditionwith their percentage.Results: Total births during the period of this studywere 4556 births, 3732 vaginal deliveries and 824cesarean sections. Cesarean section rate was found tobe 17.94% of total live births, the most frequentindication for cesarean section was malpresentation(24.3%). Primary cesarean sections contribute to 75%of cases.Conclusions: A primary cesarean section is one of themost important causes of high cesarean section rate.Decreasing the incidence of primary operations willhelp in reducing cesarean section rate.

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