research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients

Authors: Khalida M .Al-Moussawy --- Nahla Ghanim --- Wifaq M. AL-Wattar
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 111-115
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Tinea versicolor is a common dermatological problem ,world wide distribution ,caused by a dimorphic fungus called Malassezia furfur ,it live normally on skin as a commensal .Many factors play a role in the etiology of TV among these could be the disturbed immune systemwhich may be related to the ability of TV alter the immune system by a process calledImmunomodulation leading to subsequent infection.Immuno-inflammatory activity mediated by different cytokines could have a role in the etiologyof TV.Objective: To evaluate the serum level of the inflammatory cytokines ,IL-4andIL-8,in patients withTV as compared to immunocompramized patients and healthy groups.Patients and methods: This study enrolled 50 total patients, 15 of them were as patients controlgroup who were immunocompramized with evident skin lesion ,to be compared serologically with 15patients who had TV and normal immunity, the control group composed of20 healthy volunteers.Using ELISA test technique the following tests were done :detection of IL-4 and IL-8 in the sera ofall groups.Results and discussion: The statistical differences in the rate of detectable IL-4 level between TVand healthy control p< 0.001,while the difference was a highly significant between the healthycontrol and immunocompramized patients with TV,P<0.00338.The difference between twodiseased groups was(p< 0.219)which is non significant , when p<0. 05 was considered significant.IL-8 the results of our study showed a significant difference between the healthy control and thepatients with tinea versicolor, p-value was( 0.05).In this study there was a nice findings by which the difference between the healthy control and theimmunocompramized patients was highly significant as ,p<0.005.Conclusion :The genus Malassezia is an immunological paradox. In some circumstances, it actsas an adjuvant, activates the complement cascade, and elicits both cellular and humoral immuneresponses in healthy individuals, among which IL8 and IL-4 were notably increased . In contrast,it also seems to have the ability not only to evade the immune system but actually to suppress theresponse directed against


Article
HLA Antigens Among Iraqi Muslims Arabs And Kurds

Authors: Batool M. Mahdi --- Khalida M. Al-Moussawy --- Abdul Wahab A.R. Al-Shaikhly --- Ali H. Ad’hiah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 1 Pages: 94-97
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT: BACKGROUND: The HLA system is a relevant tool in population genetics analysis. From the genetic point of view, the HLA system is of general interest because of the extreme polymorphism of all known HLA loci. The allele and haplotype frequencies have a wide diversity among human population and differ in geographically and racially among populations. Iraq had a high percentage of Muslims people that distributed in two groups (Arab and Kurd). These groups are ancient populations and affected by many settlement in many centuries ago. These ancient settlements had left marks on the genetic structure of the modern Iraqi populations. The later immigrations to other countries were high in later years. The aim of study is to estimate the gene frequency of HLA class I (A, B, Cw) alleles in Iraqi Arab Muslims and Kurd Muslims and determine the genetic differences between them. METHODS: A total of unrelated 1400 Iraqi Arab Muslims (AM) and 705 Kurd Muslims (KM) healthy volunteers and individuals referred to Immunology and Tissue Typing Center in Al-Karamah Teaching Hospital for organ transplantation and Forensic medicine, were examined for HLA polymorphism using complement dependent cytotoxicity test from June-2003 to April-2004. RESULTS: The phenotypes of HLA typing of Iraqi Arab Muslims (AM) and Kurd Muslims (KM) were in agreement with Hardy-Weinberg equilibrium. Regarding HLA class I (A and Cw loci), there was a significant differences between these groups. Lasly, there was no significant difference between them in HLA-B. CONCLUSIONS: This may be due to their inhabitants different area in Iraq, and also due to their different origin as Arab and Kurd races with mild differences due to outbreeding and migration. The effects of invaders and settlements from out side the country and intermixing with them may play an important role in these differences

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2007 (1)

2006 (1)