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Article
Possible Role of Interleukins 6 and 10 in Colorectal Carcinoma in Iraqi Patients

Author: Khalida M. Mousawy,
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2005 Volume: 47 Issue: 1 Pages: 86-88
Publisher: Baghdad University جامعة بغداد

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Abstract

Background : It is quite accepted that interleukins (IL) in general play a crucial role in response to injuy , infection and on cogenic trans formation , among there are IL-6 and ILJO.Aim of this study is to find out the possible role of IL_ and IL, 10 in colo rectaI carcima in Iraqi patients.Subjects and Methods: forty patients with colorectal cancer (CRC) composed with 30 healthy controls were enrolled in this study. Serum conc. Of IL-6 and IL -lOwere estimated in both groups using ELIZA technique.Results: Serem levels of IL-6 and IL-10 were significantly increased (P<0.001) in compassion with control group.Conclusion: these cytokins could be used as a markers for tumor progression .

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Article
antimicrobial susceptibility test of microorganisms isolated from sputum culture of leukaemic patients with lower respiratory tract infections

Authors: mohammed Al-Neaimy --- suhaila Al-Salloum --- Khalida M. Mousawy,
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2005 Volume: 47 Issue: 3 Pages: 259-262
Publisher: Baghdad University جامعة بغداد

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Abstract


Article
Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients

Authors: Raghad J H AL-Akayshi --- Khalida M. Mousawy --- Eman Sh. AL-Obeidy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2009 Volume: 51 Issue: 1 Pages: 43-47
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: genetic factors were considered to play a possible role the development of autoimmune hepatitis.
Patients and methods: polymerase chain reaction-sequence specific primers (PCRSSP) was the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls.
Results: comparison between AIH patients and healthy controls showed several antigens deviations in their frequencies. HLA-A*113 (A1/-/Null) observed to play a possible risk factor in this disease while significant loss of HLA-A*2 allele were clearly observed which prompt us to believe that it could act as a protective factor, on the other hand, increased frequency of HLA-B*8 & B*14 were statistically significant in AIH which is most likely to be considered as a rather risk factor, while most HLA-B*16 were lost which led us to think of being acting as a rather protective factor.
Conclusions: this finding reflects a preliminary picture that HLA antigens might play a role in AIH susceptibility and further studies are worth being carried out.
Key words: AIH, HLA antigen, PCR-SSP.

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Article
Some Immunological Profile of Rheumatoid Arthritis

Authors: Sami Salman سامي سلمان ، ناهدة عباس ، خالدة الموسوي --- Khalida M. Mousawy --- Nahida R. Abbas
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2006 Volume: 48 Issue: 3 Pages: 293-296
Publisher: Baghdad University جامعة بغداد

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Abstract

Seventy- four cases of clinically diagnosed Rheumatoid Arthritis (RA), fifty cases of systemic lupus erythematosus (SLE), and thirty healthy normal controls were investigated for detection of rheumatoid factor (RF), total serum immunoglobulins (Igs), antinuclear antibody (ANA), and ANA subtype anti-double stranded DNA (anti-ds DNA).
Patients with RA showed 58.1% positive for RF comparable with 14% positivity in SLE patients and 6.6% in normal individuals. Serum Igs (IgA,IgG) were found to be elevated in RA and SLE patients (62.2% , 36.5%) (54% , 38%) respectively. This study revealed that ANA is found in 88% of SLE patients sera and 78% of these ANA is ds DNA in comparison with only 6.8% of RA sera were found positive for ANA.

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Article
Gene frequency and haplotype analysis of HLA class I in patients with simple renal cysts

Author: Aroub A.R Al-kaisi M.B.Ch.B, F.I.C.M.S*, Khalida M. Mousawy M.B.Ch.B, Ph.D **, Usama N. Rifat M.B.Ch.B, F.R.C.S ***
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2015 Volume: 11 Issue: 1 Pages: 58-61
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The study of human leukocytes (HLA) alleles, and haplotype frequencies within populations provide an important source of information for anthropological investigation, organ and hematopoietic stem cell transplantation as well as disease association, certain diseases showed association with specific alleles specially those of known or suspected hereditary origin or immunological basis, whether simple renal cyst is congenital or acquired is still unclear and need to be investigated.Objectives: To study the genetic aspect of simple renal cysts by detecting the gene frequency and the haplotype of HLA class I of patients with simple renal cysts, and to find the presence of these cysts in other family members.Method: Thirty patients with simple renal cysts who were attending the outpatient clinic of urosurgery in the medical city were tested for HLA class I antigen using the microlymphocytotoxicity technique, in the period from February to June 2004 compared to 50 unrelated apparently healthy individuals. Gene frequency were calculated using square root formula (g=1-√1-f), full history were taken including the family history.Results: Certain gene frequencies were higher in the patients group than in the controls, yet not reached to a statistical significant level. No haplotype association with simple renal cysts was detected in this study; family history was detected in two patients which were proved by ultrasound examination.Conclusion: Increasing the sample size may contribute to best results regarding gene frequency, haplotype and family study.Key words: Gene frequency, Haplotype, Human Leukocyte Antigens.

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