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Preparation of Condensed Polymers of Sulfonated Aminoacids with Benzidine.
تحضير البوليمرات التكاثفية للحوامض الامينية المسلفنة مع البنزدين

Authors: Firyal M.A فريال محمد علي السلامي --- Amel A.A امل عبد الامير --- Khudheyer G.K. خضير جواد كاظم
Journal: Journal of College of Education مجلة كلية التربية ISSN: 18120380 Year: 2011 Issue: 6 Pages: 333-343
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

In this paper many new condensed polymers were synthesized from reactionof sulfonated amino acids such as histidine, alanine and asparging with benzidine. Thenew condensed polymers were characterized by FTIR and UV. spectroscopy.The physical properties were measured, and the swelling % were studied withdifferent non solvents. The intrinsic viscosity was measured by Ostwald-viscometer,using DMF as a solvent The TGA and DTA were studied. The high softening pointswere measured for all condensed polymers which have higher than 240 OC. Thecontrolled release were studied in different pH values at 37 0C.The inserted moiety units of sulfonated aminoacids could enhanced thebiocompatibility, bioactivity and biodegradability properties for these preparedbiomaterials polymers, and the incorporation of aminoacids through backbone of thecondensed polymers.

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Preparation of Poly (N-Cephalexin Amic Acids) as Drug Polymers

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Abstract

Abstract:In this work new monomers have been prepared such as N-Cephalexinmaleamic acid M1 and N-Cephalexin citriconamic acid M2 , from reaction ofCephalexine with maleic anhydride and citraconic anhydride at room temperatureusing dioxane as a solvent.The new prepared monomers M1and M2 were polymerized free radicallywith AIBN as initiator to their corresponding poly amic acids P1 and P2. Whichwere converted to their sodium salt polymers P3 and P4 to enhance their solubilityin water.The physical and chemical properties were studied; the prepared monomersand polymers were characterized by FTIR, 1H-NMR and UV. Spectroscopy, theintrinsic viscosity was measured by Ostwald viscometer at 30 0C with DMF as asolvent; the drug release rate was studied. Experimental results showed that thehydrolysis of Cephalexin in alkaline medium was higher than acidic medium.

الخلاصة:سیفالكسین - N و M سیفالكسین حامض المالي امیك 1 - N حضر في هذا البحث المونومراتمن تفاعل السیفالكسین مع حامض المالیئك او الست ا ركونیك اللامائي وبدرجة ح ا ررة M حامض الست ا ركونیك 2الغرفة باستخدام الدایوكسان مذیبا.بادئا, الى البولیمرات المقابلة AIBN بالجذور الحرة باستخدام M و 2 M بلمر المونیم ا رن المحض ا رن 1لتسهیل قابلیة الإذابة بالماء. P و 4 P ثم حولت الى املاح الصودیوم للبولیم ا رت المحضرة 3 ,P و 2 P1درست الصفات الفیزیائیة للمونمرین المحضرین والبولیم ا رت المقابلة، ثم شخصت بواسطة استخدامأطیاف الأشعة تحت الحمراء والرنین النووي المغناطیسي والأشعة فوق البنفسجیة و وتم قیاس اللزوجة الجوهریةمذیبا، كما تم قیاس سرع التحرر الدوائي DMF باستخدام استوالد فسكومیتر بدرجة 30 م واستخدامللسیفالكسین وكانت في الوسط القاعدي أعلى من الوسط ألحامضي.130.23-138.35 والطاقة المصروفة لقیاس درجة التلین هي 0C تساوي P درجة التلین للبولیمر 1.207-220 0C تساوي P 190.17 ودرجة التلین للبولیمر 2 mj

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