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The Levels Of Some Serum Complement Among Seropositive Individuals After Measles Vaccination

Author: Layla S. Al-Omar
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 1 Pages: 32-35
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Measles remains a major cause of worldwide childhood mortality. The use of current live attenuatedvaccine control the disease, and measles has been targeted by the WHO for global eradicationfollowing the eradication of poliomyelitis.Objective:To determine the C3 and C4 complement response to measles virus in seropositive volunteers aftervaccination with live attenuated measles vaccine.METHODS:Thirty seven measles virus seropositive normal volunteers have been enrolled in this study, they were25 males and 12 females, their age ranged between 15-45 years. 22 of them were vaccinated withmeasles virus vaccine and 15 were injected with diluent supplied with measles virus vaccine(placebo).C3,C4 complement against measles virus were detected in volunteer's sera prior to, 1,2,3 and 4 weeksafter vaccination, using Radial Immunodiffusion Assay method.RESULTS:There was a significant difference in the concentration of serum C3 complement at week 3 ,following receipt of live measles virus vaccine in seropositive individuals, while no marked changewas observed in the concentration of C4.CONCLUSION:Rising C3 level in the sera of seropositive volunteers after measles virus vaccine administration playa role in increasing immune response against measles virus infection

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