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The effect of sulcular injection of meloxicom on biochemical parameter of rabbit

Authors: Hashim D. Musa هاشم موسى --- Lekaa M. Ibrahim لقاء ابراهيم
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 4 Pages: 88-91
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Meloxicam is an NSAID of the oxicam class that acts by inhibiting prostaglandin synthesis and inducibleCOX-2, thereby exerting anti-inflammatory effect. This study aimed to evaluate the level of alkaline phosphetase andhigh sensitivity C - reactive protein as response to sulcular injection of meloxicom using a rabbit model.Material and method: Forty five male rabbits of the same species were divided into three groups. Group 1 whichincluded 20 rabbits that injected with meloxicon in a dose equal to the human therapeutic dose /kg .Group 2 whichincluded 15 rabbits that injected with normal saline. Group 3 which included 10 rabbits used as control group. Five mlof blood was collected from the rabbits ear vien for biochemical analysis at deferent time interval. Biochemicalanalysis included alkaline phosphetase (ALP) which analyzed by using Biolabo kit and High sensitivity C- reactiveprotein (hs- CRP) was measured using ELISA technique.Results: The result showed that the level of ALP after 1 day of sulcular injection in group 1 was 101.25 then it wasdecrease to 97.50 after 14 days while mean of ALP in group 2 was 70.33 After 1 day of injection and reach to 74.67After 14 days and this almost near to the mean value of control groupStatistic description of hs-CRP for group 1 was decreased. The mean value from 11.617 after 1 day to 3.639 after 14days. For group 2 also there was decreased in the mean from 11.556 after 1 day to 3.536 after 14 days, while for thecontrol group the mean value was 3.170 .Conclusions: The sulcular injection of NSAIDs seems to be of particular interest. This may help to further reduceadverse systemic effects of NSAIDs in treatment of periodontal disease safely.


Article
Correlation between Periodontal Health Status and Salivary Matrix Metalloproteinase-9 Levels in Smoker and Non-Smoker Chronic Periodontitis Patients (A Comparative Study)

Authors: Sura D. Jassim سرى جاسم --- Lekaa M. Ibrahim لقاء ابراهيم
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 4 Pages: 128-133
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Periodontal diseases are inflammatory diseases affecting the supporting tissues of the teeth. One of the leading environmental factors that are closely related not only to the risk but also to the prognosis of periodontitis is smoking. This study aimed to evaluate the influence of smoking on periodontal health status and to measure the levels of matrix metalloproteinase-9 in smokers and nonsmokers chronic periodontitis patients, also it aimed to test the correlation between the levels of matrix metalloproteinase-9 and the clinical periodontal parameters.Materials and Methods: Five milliliters samples of un-stimulated whole saliva and full-mouth clinical periodontal recordings (plaque index, gingival index, bleeding on probing, probing pocket depth and clinical attachment level) were obtained from forty patients of two groups (non smokers with chronic periodontitis and smokers with chronic periodontitis). All subjects were systemically healthy males, with age range (35-50) years. Salivary matrix metalloproteinase-9 levels were analyzed by using Enzyme-linked Immunosorbent Assays.Results: Statistical analysis revealed that probing pocket depth and clinical attachment level were higher in smokers than non smokers, while there were decreases in the numbers of bleeding sites in smoker when compared with non smoker subjects. Salivary matrix metalloproteinase-9 levels were significantly higher in smoker with chronic periodontitis patients than their non smoker counterparts.Conclusion: Salivary matrix metalloproteinase-9, as a biomarker, could reflect the increased periodontal tissue destruction due to the smoking

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