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Article
Comparative study among aqueous, hexane extracts of sweet almond (Prunus amygdalus) with Atorvastatin for treating hyperlipidemia induced in mice

Authors: Lubna A. Kafi --- Noor TH. N. Al- Ezzi
Journal: Kufa Journal For Veterinary Medical Sciences مجلة الكوفة للعلوم الطبية البيطرية ISSN: 20779798 Year: 2015 Volume: 6 Issue: 1 Pages: 176-183
Publisher: University of Kufa جامعة الكوفة

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Abstract

This research was developed to find out the treatment impact of aqueous and hexane extracts of sweet almond (Prunus amygdalus) on some biological indicators related to hyperlipidemia that induced in mice and comparative with Atorvastatin which was dried and grinded by an electrical grinder to form fine crude powder that extracted by two ways: by using 95% hexane and water by using the distilled water with Soxhlet apparatus, (40) of mature mice were randomly separated into 8 categories (5 mouse per group) and treated every day for 60 days, the first group was fed and drank normally and regarded as a negative control group (NC1), a second group was given polypropylene glycol offered as negative control group (NC2), third group was given normal water containing 0.5% of hydrogen peroxide and 1% of cholesterol in the feed for 60 days for induction of hyperlipidemia and offered as positive control group (PC), hyperlipidemia was induced in the other five categories as in the third group. Treated hyperlipidemia by hexane extract at a dose of 500 mg/ kg of body weight and aqueous extract of sweet almond with three different doses (500, 750 and 1000) mg/ kg of bodyweight and compared with the other groups that treated with atorvastatin (Lipitor) ® 20 mg/ kg B.W. as antihyperlipidemic drug. The outcomes discovered that oral dosing with extracts of sweet almond and medication therapy led to acquire beneficial changes in the parameters, which were showed incident of a significant decrease (P<0.05) at a concentration of malondialdehyde (MDA), total cholesterol (TC), triacylglycerol (TAG), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and atherogenic index (AI) in serum, moreover to a significant improved (P<0.05) in the concentration of high density lipoprotein cholesterol (HDL-C) and serum reduced glutathione (GSH) compared with untreated group and has been proven that a dose of 1000 mg/kg of aqueous extracts of sweet almond was the best in therapy.


Article
Stability of Resistance Induced by Escherichia coli in Comparison with That Carried by Clinical Isolates in Vivo

Authors: Lubna A. Kafi --- Sajaa R. kareem Al-Saedi --- Ali A. Al-Khayyat
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2013 Volume: 6 Issue: 1 Pages: 1546-1551
Publisher: Kerbala University جامعة كربلاء

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Abstract

ackground: The increasing incidence of resistance to a wide range of antibiotics bymicroorganisms is a major concern facing modern medicine because these antibioticsare widely used in human and veterinary medicine to treat and prevent diseases and asgrowth promoters in animal intensive industries. The consequences are severe. Infectionscaused by resistant microbes fail to respond to treatment, resulting in prolonged illness andgreater risk of death.Objectives: The aims of this study are: 1-Comparing the changes of induced resistance inE.coli with that present in clinical isolates of the same microorganism. 2-Determine theproperties of cefquinome especially the development of resistance and the stability of itMethods: fourteen strains of E.coli were collected from different disease cases: diarrhea(children= 6, calve= 3, poultry= 1), UTI (urine= 2), mastitis (milk= 2) from Al-Yarmookhospital and farms of veterinary college (Baghdad). The MIC was estimated eight selectedstrains (4 sensitive and 4 resistances) before and after passages these strains in vivo forcarried out the comparison.Results: A significant drop in induced resistance for sensitive strains as compared withclinical isolates which are not significant elevate in resistance. Most E.coli strains showedhighly susceptible to cefquinome but some of them were appeared resistance although thisantibacterial was newly used in this country.Conclusion: loss of induced resistance when passing in vivo because the resistantmicroorganisms actually were unstable group when comparison with stable resistance inclinical isolates was not changed when exposed to the same condition.Keywords: E. coli, MIC, in vivo, antibacterial.

Keywords

E. coli --- MIC --- in vivo --- antibacterial.


Article
Study The Effect of Two Crude Ethanolic extracts of Eruca sativa and Zingiber officinale in comparison with Tadalafil on Sperm Parameters in Rats

Authors: Ali A. Al-khayyat --- Lubna A. Kafi --- Bassam A. A. Al-Shimmary
Journal: Kufa Journal For Veterinary Medical Sciences مجلة الكوفة للعلوم الطبية البيطرية ISSN: 20779798 Year: 2016 Volume: 7 Issue: 2 Pages: 1-4
Publisher: University of Kufa جامعة الكوفة

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Abstract

Two ethanolic extracts of Eruca sativa(Rocket) and Zingiber officinale(Ginger) were studied after 42 days of treatment with effective dose (ED)of 200 mg per kg of BW for rocket and 400 mg per kg of BW for ginger. The results indicate significant increase in sperm count for groups of rocket and tadalafil, while significant decrease in sperm motility for tadalafil as compare with control, however, no indication of significant change in sperm abnormalities for all groups as compare to control.

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Article
The Effects of Ethanolic Extracts Roots of Zingiber officinale and Leaves of Eruca sativa Extract on reproduction as compare with Tadalafil on Male Rats

Authors: Ali A. Al-khayyat --- Lubna A. Kafi --- Bassam A. A. Al-Shimmary
Journal: Kufa Journal For Veterinary Medical Sciences مجلة الكوفة للعلوم الطبية البيطرية ISSN: 20779798 Year: 2016 Volume: 7 Issue: 2 Pages: 5-8
Publisher: University of Kufa جامعة الكوفة

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Abstract

Two ethanolic extracts of Eruca Sativa (Rocket) and Zingiber officinale (Ginger) were studied after 42 days of treatment with effective dose (ED), as 200 mg per kg of B.W. for rocket and 400 mg per kg of B.W. for ginger, the results were 100% for fertility index(FI) for the two extracts , and , 60% for Tadalafil and 80% for control group. While, the result of pregnancy index(PI)was 100%, that give life babies after successful mating.

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Article
STUDY OF ACUTE TOXICITY OF DIFFERENT PREPARATION OF OLEANDER LEAVES IN MICE
دراسة السمية الحادة لثلاث تحاضير من أوراق الدفلة في الفئران

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Abstract

Three preparations of dried oleander leaves were prepared. The first one was by extraction with hexane; the second by extraction with 70% ethanol while the third was suspended as a whole ground leaves in distilled water. Different concentration of each form was prepared and the range of lethal dose in mice had estimated by pilot studies. The acute toxicity study was carried out by determine the median lethal dose (LD50) after administration of each preparation using 5 subgroups (10 mice) each receive dose range from 60-64 mg/kg, 504-536 mg/kg and 1100-1300 mg/kg for the hexane extract , ethanol extract and leave suspension respectively. The lethal dose calculated by employing probit method and found to be; 62.6 mg/kg for hexane extract, 521.0 mg/kg for ethanol extract and 1164.8 for leave suspension. This result indicates that the toxic constituents of the leaves are mostly non-polar, also that the potency of toxicity is far less than that mention in some literature.

تم عمل ثلاث مستحضرات من أوراق الدفلة المجففة ، كانت الأولى عبارة عن مستخلص الاوراق في الهكسان والثانية مستخلصها في 70 % ايثانول والثالثة عالق مسحوق الأوراق في الماء. وقد حضرت تراكيز مختلفة من كل من هذه المستحضرات وأختبرت في تجربة أولية لمعرفة مدى الجرعة القاتلة في الفئران عند اعطائها عن طريق الفم . قدرت الجرعة القاتلة الوسطية ( LD50 ) لكل مستحضر باستخدام خمس مجاميع ( 10 فئران لكل مجموعة ) ،اذ أعطيت مجاميع مستخلص الهكسان ومستخلص الايثانول وعالق الاوراق جرع تراوحت بين 60- 64 ملغم / كغم و 504- 536 ملغم / كغم و 1100- 1300 ملغم / كغم على التوالي . تم حساب ال LD50 بواسطة طريقة البروبت ووجدت بأنها 62.6 ملغم / كغم لمستخلص الهكسان و 521 ملغم / كغم لمستخلص الايثانول و 1164.8 ملغم / كغم للعالق المائي للاوراق. تدل النتائج ان المحتويات الاكثر سمية هي المتمركزة في المستخلص العضوي أي الهكسان كونها غير مستقطبة ، كذلك تشير النتائج ان شدة السمية لهذا النبات هي أقل مما ذكرته بعض المراجع .

Keywords

Hexane Extract --- Oleander --- Toxic.


Article
Effect of sweet almond suspension as anti-inflammatory in experimental infected mice with arthritis
تاثير عالق اللوز الحلو كمضاد للالتهاب في الفئران المصابة تجريبيا بالتهاب المفاصل

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Abstract

The current study was conduct to determine the effects of oral treatment of sweet Almond Suspension (SAS) on induced arthritis by Incomplete Freund’s Adjuvant (IFA).Seventy mice, with close age and weight were used; they were equally divided in to 7 groups (10 mice per group). The first group served as negative control (non infected – non treated (NINTC). The second group was the positive control (infected non treated, (NINTC) the third and fourth groups were those treated with 1.42 or 2.84 g/kg of SAS respectively. The fifth group was treated with voltarin (ITV), while the sixth and seventh groups were treated with the same closes of SAS but before infection (Prophylactic infected groups, PI1, PI2).The size of knee joint, carrageenan test, level of alkaline phosphatase and histopathological changes in the knee joint used as parameters to compare between groups. The results showed that SAS was able to subside signs of arthritis by decreasing the size of knee and decrease the formation of edema which was induced by injection of carrageenan in the paw of the animal, Histopathological study showed that joints of treated groups by SAS had no signs of arthritis. However, there was slight infiltration of netrophile in treatment and prophylactic group.

اجريت الدراسة الحالية لتحديد بعض التاثيرات التي يمكن ان يؤديها تناول عالق اللوز الحلو Sweet Almond Suspension (SAS) عن طريق الفم في علاج التهاب المفاصل المحدث تجربيا في الفئران باستخدام (Incomplete Freund’s adjuvant (IFA), استخدم في هذه الدراسة (70) فارا ذو اعمار متقاربة واوزان متساوية تقربيا قسمت الى سبع مجموعات متساوية العدد (10 فار لكل مجموعة), وهي مجموعة السيطرة غير المصابة وغير المعالجة (السالبة), ومجموعة السيطرة المصابة غير المعالجة, ومجموعتا الاصابة المعالجة بعالق اللوز الحلو وبالجرعتين (1.42-2.84) غم/كغم من وزن الجسم, والمجوعة المصابة والمعالجة بالفالتارين بجرعة (2 ملغم/كغم) من وزن الجسم (ITV) ومجموعتا الوقاية والمعاملة بعالق اللوز الحلو وبالجرعتين السابقة الذكر والمصابة بالتهاب المفاصل. اعتمد قياس مفصل الركبة وفحص الكارجينان وقياس انزيم الفوسفاتيز القاعدي والفحص النسيجي للمفصل معيارا للقياس والمقارنة بين المجاميع.اظهرت النتائج ان عالق اللوز الحلو سبب تثبيط ظهور مرض التهاب المفاصل وكذلك تثبيط الوذمة الموضعية المحدث بوساطة حقن مادة الكارجينان, وبينت الدراسة قدرة اللوز الحلو على تثبيط الالتهابات الجهازية من خلال خفض انزيم الفوسفاتيز القاعدي من خلال وجود فروق معنوية في جميع مجاميع التجربة, اما الفحص النسيجي فلم يظهر المفصل المعالج بعالق اللوز الحلو تفاعلات التهابية واضحة للمفصل في المجموعتين, وقد ظهر ارتشاح بسيط لخلايا العدلات, في المجموعات المعالجة والوقاية.

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