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Article
Assessment of serum levels of MMP-8 and hs CRP in chronic periodontitis patients in relation to atherosclerotic cardiovascular disease

Authors: Zainab J. Raheem --- Maha A. Ahmed
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 4 Pages: 141-146
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Periodontitis and Atherosclerosis Cardiovascular disease are chronic inflammatory diseases which arehighly prevalent. During the last two decades, there has been an increasing interest in the impact of oral health onatherosclerosis and subsequent cardiovascular disease. The aims of the study were to evaluate the periodontalhealth status in study groups (Atherosclerotic cardiovascular disease patients with chronic periodontitis and patientshaving chronic periodontitis),to estimate the serum levels of Matrixmetalloproteinase-8(MMP-8) and high sensitive Creactiveprotein(hs CRP) in study and control groups and compare between them. Also,test the correlationbetween the serum levels of MMP-8 and hs CRP with clinical periodontal parameters at each study groupSubjects, materials and methods: Eighty subjects, males and females were included in this study with age range (35-50) years old, they were divided into study groups [ATH+CP group: Atherosclerotic cardiovascular disease& chronicperiodontitis group (30 patients), CP group: chronic periodontitis group (30 patients)] andcontrol group: (20systemically healthy subjects, have healthy periodontium). Periodontal health status was determined by measuringthe following clinical periodontal parameters (Plaque index (PL.I), Gingival index (GI), Bleeding on probing (BOP),Probing pocket depth (PPD) and Clinical attachment level (CAL)).Serum levelsof (MMP-8and hs CRP) weredetermined by mean of ELISA.Results: The results showed that the mean values of clinical periodontalparameters (PL.I, GI, PPD and CAL), werehigher in the ATH+CP group than in the CP group with significant differences except in PL.I there was no significantdifference. A higher percentage of score 1of BOP sites demonstrated by CP groupthan in ATH+CP group with highlysignificant difference.The levels of serum (MMP-8 and hs CRP) were higher in ATH+CP groupwhen compared with CPgroup and control group, with highly significant differences between all pairs of study and control groups.Regardingthe Correlation between serum levels of (MMP-8 and hs CRP) and clinical periodontal parameters, were positivecorrelation in both study groups.Conclusion: The present results my provide evidence that Chronic Periodontitis may contribute to the inflammationassociatedto atherosclerotic process

الخلفیة :یعد مرض النساغ ومرض التصلب العصیدي من الامراض الالتھابیة المزمنة الواسعھ الانتشار . خلال العقدین الماضیین كان ھناك اھتمام متزاید في تاثیر صحة الفم علىالتصلب العصیدي ومرضالقلبي الوعائي50 )سنة. تم تقسیمھم الى مجموعتي الدراسة (ج 1 مجموعھ التصلب - الاشخاص ,المواد وطرائق العمل : 80 شخصا ذكورا واناثا ادرجوا في ھذه الدراسة تتراوح اعمارھم بین ( 35العصیدي لدیھم النساغ المزمن ( 30 مریضا) وج 2 مجموعھ النساغ المزمن ( 30 مریضا) ج 3 مجموعھ الضابطھ ( 20 شخصا اصحاء سریریا / یملكون انسجھ ماحوا الاسنان صحیة).قدرت الحالة للانسجة ماحول الاسنان عن طریق قیاس موشرات ماحول الاسنان السریریة التالیة (مؤشر الصفیحة الجرثومیة ,مؤشر التھاب اللثھ ,مؤشر النزف عند التسبیر ,مؤشرعمق الجیوب بلاظافة الى فقدان الانسجة الرابطھ سریریا). تم تحدید مستویات المصل لكل من المصفوفھ الفلزیة - 8و البروتین الارتكاسي العالي الحساسیھ باستخدام تقنیة مقایسة الانزیمالمرتبط الممتز المناعيالنتائج :اظھرت النتائج ان قیم المتوسط الحسابي لكل من ((مؤشر الصفیحة الجرثومیة ,مؤشر التھاب اللثھ , ,مؤشر عمق الجیوب بلاظافة الى فقدان الانسجة الرابطھ سریریا) اعلى لدىج 1 من ج 2 .ھنالك نسبة عالیھ لمناطق التسبیر عندج 2 من ج 1 مع فروقات معنویة عالیة . مستویات المصل لكل من من المصفوفھ الفلزیة - 8و البروتین الارتكاسي العالي الحساسیھكانت اعلى عند ج 1 عند مقارنتھا مع ج 2 وج 3 مع وجود فروقات معنویة عالیة بین كل ثنائي من مجموعات الدراسة والضابطھ . فیما یخص العلاقھ بین مستویات المصل لكل من منالمصفوفھ الفلزیة - 8و البروتین الارتكاسي العالي الحساسیھ ومؤشرات ماحول الاسنان السریریھ كان ھناك ارتباط معنوي طرديالاستنتاج :النتائج الحالیة قد توفر دلیل على ارتباط بین مرض النساغ المزمن ومرض التصلب العصیدي . وتشیر الى ان مرض النساغ قد یلعب دورھاما في الالتھاب المصاحبلمرضالتصلب العصیدي


Article
Assessment of some salivary enzymes levels in type 2 diabetic patients with chronic periodontitis (Clinical and biochemical study)

Authors: Ghasaq A. Abdul-wahab --- Maha A. Ahmed
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 1 Pages: 138-143
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Diabetic patients have been reported to be more susceptible to gingivitis and periodontitis thanhealthy subjects. Many intracellular enzymes like (alkaline phosphatase- (ALP), aspartate aminotransferase- (AST)and alanine aminotransferase- (ALT) that are released outside cells into the gingival crevicular fluid (GCF) and salivaafter destruction of periodontal tissue during periodontitis. This study was conducted to determine the periodontalhealth status and the levels of salivary enzymes (ALP, AST and ALT) of the study and control groups and to correlatethe levels of these enzymes with clinical periodontal parameters in each study group.Subjects, Materials and Methods: One hundred subjects were enrolled in the study, with an age range of (35-50)years, only males were included. The subjects were divided intostudy groups (group-I consists of 30 patients withcontrolled type 2 diabetes mellitus(T2DM), group-II consists of 30 patients with uncontrolled T2DM, group-III consists of25 patients non-diabetics, all of them have chronic periodontitis(CP) and group-IV consists of 15 apparentlysystemicallyhealthy subjects and have healthy periodontium, as control group. Unstimulated saliva samples werecollected for biochemical analysis of salivary enzymes (ALP, AST and ALT).The clinical periodontal parametersincluding: plaque index (PLI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD) andclinical attachment level (CAL) were recorded for all subjects at four sites per tooth except third molars.Results: All clinical periodontal and biochemical parameters were highest in uncontrolled T2DM with CP patients andall enzymes levels revealed highly significant differencesbetween all pairs of the study and control groups except ASTenzyme level which demonstrated a non-significant difference between controlled T2 diabetics with CP and nondiabeticswith CP. There were weak correlations between all clinical periodontal parameters and biochemicalparameters except between PPDand ALT enzyme in non-diabetics with CP group and between CAL and ASTenzyme in uncontrolled T2 diabetics with CP which demonstrated highly significant strong positive correlations.Conclusion: It was concluded that T2DM and poor glycemic control have negative impact on periodontal healthstatus. Salivary enzymes were considered as good biochemical markers of periodontal tissue destruction and usefulin diagnosis, monitoring and efficient management of periodontal diseases and T2DM


Article
Assessment of Salivary Lactoferrin and pH Levels and Their Correlation with Gingivitis and Severity of Chronic Periodontitis (Part: 2)

Authors: Haider J. Talib --- Maha A. Ahmed
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2018 Volume: 30 Issue: 1 Pages: 46-52
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Periodontal diseases are bacterial infections of the gingiva, bone and attachment fibers that support the teeth and hold them in the jaw. Lactoferrin is a multifunctional glycoprotein and it is the main component of neutrophil polymorphonuclear leukocytes that activated during inflammatory processes such as Periodontal diseasesAims of the study: Determine the salivary levels of Lactoferrin and pH and their correlations with clinical periodontal parameters(Plaque Index , Gingival Index , Bleeding on Probing , Probing Pocket Depth , and Clinical Attachment Level ) and the correlation between Lactoferrin with potential of hydrogen ion (PH) ,flow rate and α-amylase of study groups that consisted of patients had gingivitis and patients had chronic periodontitis with different severities(mild ,moderate ,severe) and control group .Materials and Methods: Salivary Lactoferrin and pH levels were measured from 75 males, age ranged (30-45) years old, that divided into study groups (group of 45 chronic periodontitis patients with different severities which sub-grouped into (Mild=15, Moderate=15 and Severe=15), group of 15 patients with gingivitis) and control group comprised 15 subjects had clinically healthy periodontium.Results: The levels of salivary Lactoferrin in patients had severe chronic periodontitis were the highest followed by moderate chronic periodontitis then the mild chronic periodontitis then patients had gingivitis. Highly significant differences were demonstrated among the control, gingivitis and chronic periodontitis subgroups and between each pairs of chronic periodontitis subgroups. pH increased in gingivitis group and decreased in chronic periodontitis group with its different severities. Highly significant strong positive correlations between Lactoferrin with clinical periodontal parameters at all groups and subgroups.Conclusions: The findings of the present study suggest that salivary Lactoferrin can help to monitor the progression of the periodontal disease


Article
Assessment of Salivary α-amylase and Flow Rate Levels and Their Correlation with Gingivitis and Severity of Chronic Periodontitis (Part: 1)

Authors: Haider J. Talib حيدر طالب --- Maha A. Ahmed مها احمد
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 4 Pages: 115-121
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Periodontal diseases are bacterial infections of the gingiva, bone and attachment fibers that support the teeth and hold them in the jaw. α-amylase is an enzyme, produced mainly by parotid gland and it seems to play a role in maintaining mucosal immunity.Aims of the study: Determine the salivary levels of α-Amylase and flow rate and their correlations with clinical periodontal parameters(Plaque Index , Gingival Index , Bleeding on Probing , Probing Pocket Depth , and Clinical Attachment Level ) and the correlation between α-Amylase with flow rate of study groups that consist of ( patients had gingivitis and patients had chronic periodontitis with different severities(mild ,moderate ,severe) and control group .Materials and Methods: Salivary α-Amylase and flow rate levels with clinical periodontal parameters(Plaque Index , Gingival Index , Bleeding on Probing , Probing Pocket Depth , and Clinical Attachment Level ) were measured from 75 males , age ranged (30-45) years old, that divided into study groups(group of 45chronic periodontitis patients with different severities which sub-grouped into (Mild=15, Moderate=15 and Severe=15), group of 15 patients with gingivitis) and control group comprised 15 subjects had clinically healthy periodontium.Results: The levels of salivary α-amylase in patients had chronic periodontitis were the highest followed by patients had gingivitis .Highly significant differences were demonstrated between each pairs of chronic periodontitis subgroups hence, the highest level at severe chronic periodontitis subgroup patients. Flow rate decreased in gingivitis group and chronic periodontitis with its different severities. Highly significant strong positive correlations were found between α-amylase with clinical periodontal parameters at all groups and subgroups.Conclusions: The findings of the present study suggest that salivary α-Amylase can help to monitor the progression of the periodontal disease.


Article
Evaluation of serum levels Superoxide dismutase in women with polycystic ovarian syndrome and gingivitis

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Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women, there is an increasing evidence for an oxidative stress in PCOS that induce genomic and mitochondrial deoxyribonucleic acid damage that leads directly to reduced fertility. The objectives of this study are to assess and compare the periodontal health status by measuring clinical periodontal parameters (PLI, GI and BOP)as well as serum levels of superoxide dismutase at gingivitis ,gingivitis with PCOS and healthy periodontium groups, then correlate between clinical and biochemical parameters.Materials and Methods: 60 females with an age range between (25-40) years old had been tested and divided into3 groups ,the control group consists of (20) females with healthy periodontium, group of (20) females with gingivitis and group of (20) females with gingivitis and PCOS. After completion of clinical periodontal parameters recording (PLI, GI& BOP), blood samples were collected and biochemical analysis of serum samples were carried out by using [Super oxide dismutase Assay kit] to evaluate serum super oxide dismutase levels.Results: The highest mean values of PLI,GI and BOP score1 were found in gingivitis+PCOS group. Highly significant difference was revealed among the groups regarding mean values of Superoxide dismutase with the highest mean value at gingivitis+ PCOS followed by gingivitis groups. Non-significant correlation were demonstrated between clinical and biochemical parameters except the significant moderate positive correlation of BOP at gingivitis+PCOS group.Conclusion: It could be certified that severity of gingivitis may increase in patients with PCOS. The concentration of serum SOD increased with the severity of gingival inflammation as well as the presence of PCOS. Serum SOD may be useful biochemical marker for early detection of periodontal disease and PCOS

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