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Article
Bacteriological and immunological study of aggressive periodontitis in Mosul

Authors: Alaa M. Altaei --- Mahmoud Y.M. Taha
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: 3 Pages: 207-214
Publisher: Mosul University جامعة الموصل

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Abstract

Aims of the study: to isolate and identify microorganisms causing aggressive periodontitis, and to estimate the changes in the levels of IL-1, TNF- and CRP in serum as well as to determine peroxidase activity in saliva of patients with aggressive periodontitis. Materials and Methods: This study was carried out on total number of 40 (35 patients with aggressive periodontitis, 18 females and 17 males aged between 16-35 years and 5 control group between 20-30 years old). Samples were taken from the lesion for bacteriological study. Serum and saliva were collected and ELISA test was performed. Results: The bacteriological results showed that A. actinomycetemcomitans was the most prevalent bacteria in aggressive periodontitis, followed by facultative anaerobic. The serological and biochemical studies showed that interleukin-1 was significantly elevated in the study group while tumor necrosis factor was not, whereas peroxidase enzyme activity and C-reactive protein were also highly significant elevated in the study group. Conclusion: Actinobacillus actinomycetemcomitans was the major etiologic bacteria of this disease as well as significantly high levels of, CRP, peroxidase activity and IL-1 could be regarded as strong markers for more precise understanding the immunological aspect of this disease


Article
Efficiency of diode laser and sodium hypochlorite as root canal disinfectant against Enterococcus Faecalis: An In vitro study

Authors: Mahmoud Y.M. Taha --- Nawfal A. Zakaria --- Nagwan F. Shehab
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: 3 Pages: 330-338
Publisher: Mosul University جامعة الموصل

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Abstract

Objectives: The main objective of the current in vitro study is to compare the antimicrobial efficiency of diode laser 1064nm at different output powers and times with sodium hypochlorite at different concentrations and times against E. faecalis when used as root canal disinfectant. Materials and methods: 140 human extracted single-rooted teeth were decoronated to a length 14mm from the apical foramen to the cervical border of the root, then adjusted working length to 13mm, autoclaved and inoculated with a suspension of E. faecalis at a concentration 4×105 cfu and incubated at 37˚C for 24 hours. Samples were divided into 14 groups each group consisted of 10 prepared roots, sixty samples were irrigated with NaOCl solution at different concentrations and times. Sixty samples were irradiated at different powers at the total irradiation time 30 and 60 sec, the remainder twenty samples were control positive and negative groups. Results: All concentrations, powers and times for both diode laser 1064nm and NaOCl had significant antimicrobial effects against E. faecalis. 5.25% NaOCl at both 2 minutes and 5 minutes had the highest antimicrobial effect with no significant differences from 3W laser/10sec and 2.5W/10sec for (6 cycles) but significantly different from 3W/5sec (6 cycles). The lowest effect was 0.5% NaOCl/2min that significantly different from all other groups. Conclusion: Diode laser device seems to be highly suitable for killing E. faecalis as NaOCl irrigant in root canals if appropriate energy and irradiated time used


Article
Biochemical and immunological study of saliva in relation to oral health status in thalassemia major patients in Mosul

Authors: Mahmoud Y.M. Taha --- Raja H. Al-Jubori --- Ahmed S. Khudhur
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: 3 Pages: 265-276
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: The present study aimed to investigate some biochemical (Lysozyme and Peroxidase enzymes) and immunological (S-IgA) changes in saliva of thalassemia major patients and the correlation of these changes with the oral health status measured by the dmft/DMFT (decay, missing, filling tooth index for deciduous and permanent dentition), plaque and gingival indices.Materials and Methods: The study was carried out in Ibn Al-Atheer Teaching Hospital in Mosul and involved (91) subjects. The study group (70 thalassemia major patients) and the control group (21 normal non-thalassemic subjects). The study group was divided into two subgroups (35 each) according to the history of disease. Data was collected from each patient including medical status and oral health status indices and saliva samples were collected from each patient and stored at -20 oC to be analyzed for salivary Lysozyme by lysoplate method, salivary Peroxidase activity and salivary secretary S-IgA by ELISA.Results: Showed that the dmft/DMFT plaque and gingival indices in thalassemia major patients were significantly higher (P < 0.001) than normal subjects. The salivary lysozyme in thalassemia major patients was significantly lower (P < 0.001) than normal subjects. The salivary peroxidase activity was nearly higher in thalassemic patients than normal subjects. The salivary S-IgA in thalassemic patients was significantly lower (P < 0.001) than normal subjects. Conclusions: The study showed a significant correlation between the changes in some of the salivary constituents and the high prevalence of dental caries, plaque and gingivitis in thalassemia major patients

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