research centers


Search results: Found 14

Listing 1 - 10 of 14 << page
of 2
>>
Sort by

Article
Radiation Stimulates Nitric Oxide Release from Isolated Protein of Patients with End Stage Renal Failure: In Vitro Study

Author: Marwan S. M. AL-Nimer
Journal: Al-Mustansiriyah Journal of Science مجلة علوم المستنصرية ISSN: 1814635X Year: 2012 Volume: 23 Issue: 2 Pages: 1-10
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

It is well known that exposure of human protein to the ultraviolet radiation resulted in denaturation. Few data explore the importance of the production of non enzymatic nitric oxide from endogenous sources. This study is aimed to explore the effect of ultraviolet radiation, monochromatic light and day light on the production of non-enzymatic nitric oxide from isolated serum protein of patients with end stage renal failure. The sera protein of 12 patients with end stage renal failure were isolated by precipitation methods and exposed to UVA (365 nm), UVC (254 nm), monochromatic light (sodium lamp; 589.3 nm) or sun light for 2hours. Nitrogen species in term of nitric oxide and peroxynitrite were determined in patients sera, and in the protein aliquots before and after irradiation. Production of non-enzymatic nitric oxide was significantly observed in protein aliquot exposed to UVA (1586±763.8 μmol), monochromatic light (1047.7±397.7 μmol) and UVC (919.3±794.6) compared to that exposed to the sun light (687.7±531.4 μmol). It concludes that ultraviolet radiation or monochromatic lighting are good stimulator of nitric oxide production from isolated sera protein of patients with end-stage renal failure. Such effect may produce harmful as well as beneficial effect.Key words: Nitric oxide. Serum protein, Renal failure

من المعروف ان تعرض البروتين البشري الى الاشعة فوق البنفسجية يحصل له تمسخ . وان معلومات قليلة قد اوضحت اهمية انتاج اوكسيد النتريك بطريقة غير انزيمية من مصادره داخلية المنشأ . هدفت الدراسة لكشف تأثير التشعيع بالأشعة فوق البنفسجية، ضوء احادي اللون وضوء الشمس على انتاج تحرر اوكسيد النتريك بتفاعل غير أنزيمي من بروتين مصل الدم المعزول من مرضى الفشل الكلوي في مرحلته النهائية. عزل بروتين مصل 12 من مرضى الفشل الكلوي في مرحلته النهائية بطريقة الترسيب وتم تعريضه الى الأشعة فوق البنفسجية نمط A(طول الموجي 365 نانومتر) ، الأشعة فوق البنفسجية نمط C (طول الموجي 254 نانومتر)، ضوء احادي اللون (مصباح صوديوم ذو طول موجي 589.3 نانومتر) او اشعة الشمس لمدة ساعتين. تم قياس مستويات الانواع النتروجينية بصورة اوكسيد النتريك وبيروكسي نتريت في مصل المرضى وفي مستخلص البروتين قبل وبعد التشعيع . فقد لوحظ زيادة في انتاج اوكسيد النتريك بطريقة غير انزيمية من مستخاص البروتين عند تعرضة الى الأشعة فوق البنفسجية نمط A(1586±763.8 ماكرومول) ، الأشعة فوق البنفسجية نمط C (919.3±794.6ماكرومول)، ضوء احادي اللون (919.3±794.6 ماكرومول) مقارنة بضوء الشمس (687.7±531.4). نستنتج ان الاشعة فوق البنفسجية او الضوء احادي اللون محفز حيد لانتاج اوكسيد النتريك من البروتين المعزول من مرضى الفشل الكلوي في مرحلته النهائية وان مثل هذا الفعل قد يتسبب بتأثيرات ضارة ونافعة.مفتاح الكلمات: اوكسيد النتريك، بروتين المصل، الفشل الكلوي

Keywords


Article
The limitations and pitfalls in clinical implications of Bragg's peak: A theoretical SRIM – TRIM model of human breast tumor

Author: Marwan S.M. Al-Nimer
Journal: Al-Mustansiriyah Journal of Science مجلة علوم المستنصرية ISSN: 1814635X Year: 2010 Volume: 21 Issue: 5 Pages: 103-122
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Proton beam therapy is unique because it allows for minimal scattering as particulate beam pass through tissue and deposing ionizing energy at precise depth i.e. Bragg peak. This study is aimed to investigate the limitations and pitfalls in clinical application of Bragg peak in theoretical model of human breast tumor. The Microsoft; "The Stopping and Range of Ions in Matter (SRIM)" version 1998, and 2003 was used. A model of breast tumor was designed and the projection of irradiated ions (hydrogen or carbon) crossed multi-layers including skin, adipose tissue, normal and abnormal breast tissues of different densities. The results showed that the stopping power of carbon ions was higher than corresponding hydrogen ions and proportionally increased with tissue density. The longitudinal range was directly correlated with acceleration potential energy for both hydrogen and carbon ions. The straggling of the hydrogen ions and to lesser extent the carbon ions tended to be declined, for each accelerated potential, with increment in density of breast tissue. The energy loss was higher with carbon ions compared with hydrogen ions. Irradiation with hydrogen or carbon ions resulted in breast tissue damage which was proportionally related to the accelerated potentials and inversely with target density. The damaging effect of carbon ions was inferior to that of hydrogen ions. It concludes that typical Bragg's peak can be achieved when the density of irradiated tissue , the localization of abnormal tissue , the type of ions radiation and the acceleration potentials are taken collectively in consideration.

تعد معالجة حزمة البروتون فريدة لأنها تسمح بوضع طاقتها الأيونية في عمق محدد مع تبعثر ضئيل جدا في الطاقة والتي تعرف بقمة براك. هدفت الدراسة الى التقصي عن الهفوات التي يمكن ان تحصل عند تطبيق قمة براك لنموذج نظري لأورام الثدي في الانسان. تم استعمال برنامج سرم – ترم طبعة 1998 و2003 وتم تصميم نموذج لسرطان الثدي بحيث تخترق الايونات (الهيدروجين او الكاربون) وبطاقات مختلفة طبقات الجلد والشحم وانسجة الثدي الطبيعية ونسيج ورم في الثدي ذو كثافات مختلفة. اظهرت النتائج ان الطاقة المكبوحة للكاربون هي اكبر من الهيدروجين وتتناسب طرديا مع كثافة النسيج. وتناسب المدى الأفقي عند اختراق الأيونات مع الطاقة المسلطة وقد تدنى اقتحام ايونات الهيدروجين بزيادة كثافة نسيج الورم في حين كانت الطاقة المفقودة في الورم عالية مع تشعيع الكاربون. وقد تسبب التشعيع الأيوني الذي تناسب طرديا مع الطاقة المسلطة وعكسيا مع كتلة الورم في تلف الورم . نستنج من هذه الدراسة انه بالأمكان الحصول على قمة براك وتطبيقه في معالجة اورام الثدي اذا ما اخذ بنظر الاعتبار كثافة او كتلة الورم ، و موضع الورم في النسيج الطبيعي و طبيعة الأيون المشعع والطاقة المسلطة مجتمعة.

Keywords


Article
Glutamine addiction: A fatal ignorance in prescription of glutamine supplementation

Author: Marwan S.M. Al-Nimer
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2015 Volume: 14 Issue: 1 Pages: 85-88
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Keywords


Article
Measurements of serum high sensitivity C-reactive protein, and procalcitonin levels in type1 and 2 Diabetes complicated with diabetic foot syndrome
قياسات C-reactive protein عالي الحساسية ، ومستويات البروكالسيتونين في داء السكري من النوع 1 و 2 المصحوبة بالمضاعفات بسبب متلازمة القدم السكرية

Authors: Zhian M.I. Dezayee --- Marwan S.M. Al-Nimer
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2017 Volume: 21 Issue: 3 Pages: 1869-1877
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objective: There is evidence that the procalcitonin levels are usually correlated with the high sensitivity C-reactive protein levels in inflammatory conditions. Therefore, this study aimed to assess the simultaneous changes of the procalcitonin and hs-CRP levels in the diabetic foot syndrome complicated type 1 and 2 diabetes.Method: This observational study was carried in the Center of Diabetes Mellitus in Erbil, Iraq from 1st January to the 30th September 2015. A total number of 170 participants were enrolled in this study. They grouped into Group I (healthy subjects, n=30), Group II (type 1 diabetes with diabetic foot syndrome, n=70) and Group III (type 2 diabetes with diabetic foot syndrome, n=70). The anthropometric measurements, blood pressure, fasting serum glucose and lipid profile, and the inflammatory markers included high sensitivity C-reactive protein and procalcitonin were determined.Results: Group III patients had a significant longer duration and score of diabetic foot syndrome, higher anthropometric measurements, higher blood pressure and fasting lipid profile levels compared with Group II. Serum procalcitonin and high sensitivity C-reactive protein levels were significantly higher in diabetic patients compared with Group I subjects. The serum levels of procalcitonin and high sensitivity C-reactive protein of Group III patients (1.11±0.47 ng/ml; 12.48±2.57 mg/L) were significantly higher than corresponding values of Group II patients (0.334±0.094 ng/ml; 5.73±0.89 mg/L). A non-significant correlation between procalcitonin with high sensitivity C-reactive protein in Group II and III was observed.Conclusion: We conclude that the simultaneous measurements of high sensitivity C-reactive protein and procalcitonin as inflammatory biomarkers are not necessary because the correlation was not significant.


Article
Effect of chlorpromazine on intact and irradiated aliquot

Authors: Mohammad A. ALhamdany* --- Marwan S.M. Al-Nimer --- Ali M. Abbed*
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 157-161
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Bagkground:Chlorpromazine is widely used in human medicine in the therapy of schizophrenia,organic psychosis and the manic phase of manic depressive illness. It expressed a selectivecytotoxicity and the results of genotoxicity were positive.Objectives: This study is designed to explore the effect of chlorpromazine on irradiated and nonirradiated calf thymus double strands DNA (ctdsDNA) molecule.Methods: Aliquots of irradiated (subjected to UVB light) and non-radiated ctdsDNA sampleswere incubatyed with different concentrations of chlorpromazine. Further series of experimentsstudied the simultaneous effects of chlorpromazine and UVB light on aliquots of ctdsDNA, Thechanges in optic densities of ctdsDNA aliquots were mointered and recorded bu UVspectrophotometerat 260 nm.Results: Chlorpromazine exerts dual effects on non-radiated ctdsDNA aliquots represented byhyperchromasia and hypochromasia in regard to its concentration. It potentiates the effect of UVBradiation on ctdsDNA molecules. Its effect is differed in respect to the radiation status.Conclusion: chlorpromazine exerts several effects on aliquot ctdsDNA samples which arerelated to the nature of DNA molecule as well as to the concentration of chlorpromazine.Alsochlorpromazine potentiates the hyperchromasic effect of UVB radiation on aliquot ctdsDNAsamples but it produces completely damage of DNA molecule when the aliquot ctdsDNA samplesirradiated in presence of chlorpromazine.

Keywords


Article
Ciprofloxacin but not amoxicillin significantly elevated serum peroxynitrite level in patients with enteric (typhoid fever): In vitro study

Authors: Nada A. Abd al-Husain Al-Jrah --- Marwan S.M. Al-Nimer
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 3 Pages: 305-308
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Peroxynitrite is one intermediate of reactive nitrogen species with bactericidal and cylotoxic effects. Fluoroquinolones. drugs used for salmonella infections, are interacted vith nitrogen species and their baeterieida effect is influenced by these species. This study aims to assess serum peroxynitrite level in patients with enteric (typhoid) fever and. to investigate the effect of ciprofloxacin or amoxicillin on serum peroxynitrite level as well as in aqueous buffer solution in vitro. Thirty patients with enteric fever diagnosed clinically and serologically and twenty healthy individuals served as controls were admitted in this study. None of our sample was received anli-salmonellosis agents. Our results show that serum peroxynitrite level tended to be significantly less in patients with typhoid fever in comparison with controls. In in vitro experimental model, ciprofloxacin but not amoxicillin at 6.25 ug elevate significantly serum peroxynitrite level. In aqueous solution, the ability of ciprofloxacin to produce peroxynitrite is higher than that of amoxicillin. We conclude that Ciprofloxacin . as bactericidal agent against salmonellosis, may act via producing or elevating peroxynitrite level.

Keywords


Article
The Clot-lysis Effect of Selective α1-Adrenoceptor Antagonist in Vitro Model Associated with High Peroxynitrite Level

Authors: Marwan S.M. Al-Nimer --- Ali Ismail A. AL-Gareeb --- Hayder M. Al-Kuraishy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 2 Pages: 269-272
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Alpha1-adrenoceptor blocking agents showed several effects beyond their action on the vascular smooth muscles. They improve the lipid profile and inhibit the aggregation of blood platelets.OBJECTIVE:To investigate the clot-lysis effect of selective α1-adrenoceptor antagonists and its relation to peroxynitrite level in vitro experimental model.MATERIALS AND METHODS:Venous blood samples obtained from ten healthy subjects. To each pre-weighed clot, 100 μL of either distilled water as a negative control, prazosin (10 μg), terazosin (20 μg) and alfuzosin (25 μg) were added. Peroxynitrite level was measured in sera and sangious fluid that formed after clot-lysis.RESULTS:Prazosin, terazosin and alfuzosin,in order, significantly reduced the clot weight up to 3.7%. Peroxynitrite level in sangious fluids was higher in treated groups than that of negative control or sera levels.CONCLUSION:α1-adrenoceptor antagonists induced clot-lysis effect. This effect is associated with generation peroxynitrite


Article
Assessment of therapeutic modalities of aseptic subacromial bursitis in Iraqi patients

Authors: Riyadh A. Sakeni --- Marwan S.M. Al-Nimer --- Rafid.A.jassam alkhazaly
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2011 Volume: 24 Issue: 4 Pages: 331-334
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Objectives: This study is aimed to evaluate the beneficial effect of intra-bursal injection of single dose of triamcinolone acetonide and lidocaine mixture in patients with subacromial bursitis and to practice it as dramatic outpatient response. Methods: Patients with shoulder pain who referred to the outpatient consultant clinic of rheumatic diseases at Al-Yarmouk teaching hospital in Baghdad, Iraq were allocated for the study. One hundred patients fulfilled the clinical diagnosis of subacromial bursitis were managed either with injection of a mixture of triamcinolone acetonide (40 mg/ml) and 1ml of 2% lidocaine in the subacromial bursa (Group I, n= 56) or oral nonsteroidal anti-inflammatory drugs (NSAIDs) combined with ultrasound therapy (Group II, n=44). The patients were clinically assessed. Results: Full recovery was observed in all patients of group I, while only 5 patients were responded in group II (one of them is on selective cyclooxygenase enzyme inhibitors). A trial of intra-bursa injection of triamcinolone acetonide and lidocaine was done to patients not responded (n =39) to NSAIDs (Group II). The trial showed full recovery in 34, partial recovery in 4 and no effect in one patient. Diabetic patients responded better to intra-bursa steroid than NSAIDs (12 vs 1 respectively).Conclusion: We concluded that intra-bursa injection of a triamcinolone acetonide and lidocaine mixture afforded high percent of recovery within short period of time. Key words: Subacromial bursitis, Triamcinolone acetonide, nonsteroidal anti-inflammatory drugs.


Article
Short Term Effects of Antiepileptic Drugs on the Heart Using Electrocardiograph as an Assessment Tool of Investigation: A Pilot case Finding Study

Author: Sura A. Al-Mahdawi *, Marwan S.M. Al-Nimer**,Namir M.T. Bdullah ***
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 4 Pages: 492-498
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND: Antiepileptic drugs can induce changes in the electrocardiograph (ECG) records including prolongation of QT interval but there is no evidence to link this effect with the sudden death that reported in epilepsy. The new generations of antiepileptic drugs showed variable effect on the heart. Lamotrigine did not prolonged the QT interval in healthy subjects while levetiracetam prolonged the QT interval in patients cardiac channelopathy presented with congenital long QT syndrome.OBJECTIVE:This study aimed to investigate effects of antiepileptic drugs that prescribed in a therapeutic regimen to new cases of epilepsy as a part of management on the ECG records at the end of the 1st three months of treatment.PATIENTS AND METHODS: A total number of 25 patients, presented for the first time with epilepsy, were recruited from Al-Yarmouk Teaching hospital. Each patient was assessed clinically by consultant neurology prior to enrollment in the study. An electrocardiogram (ECG) was obtained at the time of entry into the study prior to the admission of the study and after three months of treatment with antiepileptic drugs. In addition to the measurements of heart rate and different ECG intervals, a QT-nomogram and cardiac restitution were used in analysis.RESULTS:At the time of entry, three patients had a significant short corrected QT interval (QTcB); four patients had a borderline QTcB interval; and one patient had prolonged QTcB interval. QT-nomogram revealed that many patients have abnormal interval and antiepileptic drugs significantly reduced the relaxation phase of cardiac cycle and prolonged the ventricular repolarization.CONCLUSION:Antiepileptic drugs carried a harmful effect on the heart and their assessment should be not restricted in the measurement of QT interval before and after treatment or to study their effects on the healthy subject as epilepsy is commonly associated with mutation of sodium and/or potassium channels. Case finding of significant prolonged QT interval in respect to gender and age, assessment of QT nomogram and cardiac restitution are useful tools to identify the patients who are at risk of arrhythmias.

Keywords

KEY WORDS: epilepsy --- ECG --- QTcB --- restitution.


Article
Effects of vitamin D supplementation on red cell indices and cytokines in patients with thalassemia: An open-label randomized clinical trial
آثار مكملات فيتامين (D) على مؤشرات الخلايا الحمراء ومستويات السيتوكينات في المرضى الذين يعانون من ثلاسيميا بيتا الرئيسية; تجربة سريرية عشوائية ذات علامة مفتوحة.

Authors: Raz Muhammed HamaSalih راز محمد حمه صالح --- Marwan S.M. Al-Nimer مروان صالح النمر
Journal: Al-Mustansiriyah Journal for Pharmaceutical Sciences مجلة المستنصرية للعلوم الصيدلانية ISSN: 18150993 Year: 2019 Volume: 19 Issue: 4 Pages: 170-179
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Background and aimDeficiency of vitamin D is known as a health problem all over the world and a recognized clinical complication of beta thalassemia patients. Vitamin D acts as a hormone at the nuclear receptor rendering it a beneficial medication for a number of diseases. It is believed that vitamin Dis important in the modulation of the inflammation system by regulating the formation of inflammatory cytokines and immune cells. This study aimed to investigate the effect of vitamin D supplementation on the red cell indices and cytokines levels in patients with beta thalassemia major, in an open label randomized clinical trial.Patients and Methods: this study performed an open-label randomized clinical trial in patients with beta thalassemia major. Forty-six patients completed the eight weeks clinical trial and were allocated to administer oral vitamin D3 supplement of 100,000 IU every two weeks as an add-on treatment. During the study, hematological indices, serum iron, ferritin, vitamin D, calcium and inflammatory markers (interleukin-6, interleukin-2 and interleukin-10) were evaluated before (at baseline) and after vitamin D supplementation for 8 weeks.Results: Vitamin D3 supplements significantly decreases interleukin-6 levels and elevates the serum levels of anti-inflammatory cytokines IL-2 and IL-10, it also significantly reduced serum ferritin level, but it did not alter the hematological indices.Conclusion: Our results suggest that administration of vitamin D has a potential anti-inflammatory role in beta thalassemia patients and reduces serum ferritin levels, which may reduce the burdens of iron overload in thalassemia patients.

خلفية:يعرف نقص فيتامين (D) بأنه مشكلة صحية في جميع أنحاء العالم ومضاعفات سريرية معترف بها لمرضى الثلاسيميا بيتا. يعمل فيتامين (D) كهرمون في المستقبل النووي مما يجعله دواء مفيد لعدد من الأمراض. ويعتقد أن فيتامين (D) مهم في تعديل نظام الالتهابات من خلال تنظيم تشكيل السيتوكينات الالتهابية والخلايا المناعية.الهدف: تهدف هذه الدراسة إلى دراسة آثار مكملات فيتامين (D) على مؤشرات الخلايا الحمراء ومستويات السيتوكينات في المرضى الذين يعانون من ثلاسيميا بيتا الرئيسية، في تجربة سريرية عشوائية ذات علامة مفتوحة.الإعداد: مركز الثلاسيميا ، دليل الصحة ، المستشفى العام فی السليمانية، إقليم كوردستان - العراق.الطريقة:أجرينا تجربة سريرية عشوائية مفتوحة التسمية علی المرضى الذين يعانون من ثلاسيميا بيتا الرئيسية. أكمل ستة وأربعون مريضا التجربة السریریة (الكلينيكية) التي استمرت ثمانية أسابيع وتم تخصيصها لإعطاء مكملات فيتامين D3عن طريق الفم والتي تبلغ 100000 وحدة دولية IU كل أسبوعين كعلاج إضافي. خلال الدراسة، تم تقييم مؤشرات الدم، الحديد في الدم، فيريتين، فيتامين D ، الكالسيوم وعلامات الالتهابات (إنترلوكين -6، إنترلوكين -2 وإنترلوكين -10) قبل (في الأساس) وبعد مكملات فيتامين (D) لمدة ثمانیة أسابيع.النتائج: مكملات فيتامين D3 تقلل بشكل كبير مستويات إنترلوكين -6 وترفع مستويات مصل السيتوكينات المضادة للالتهابات IL-2 و IL-10 ، كما أنه يقلل بشكل كبير من مستوى فيريتين المصل، لكنه لم يغير مؤشرات الدم.خاتمة:تشير نتائجنا إلى أن تناول فيتامين (D) له دور محتمل مضاد للالتهابات في مرضى الثلاسيميا بيتا ويقلل من مستويات فيريتين المصل، مما قد يقلل من أعباء الحديد الزائدة في مرضى الثلاسيميا.

Listing 1 - 10 of 14 << page
of 2
>>
Sort by
Narrow your search

Resource type

article (14)


Language

English (12)


Year
From To Submit

2019 (1)

2017 (1)

2016 (1)

2015 (2)

2014 (1)

More...