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Article
Viral hepatitis markers screen in children with cute Lymphoblastic Leukemia

Author: Mazin F. Al-Jadiry
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2008 Volume: 50 Issue: 2 Pages: 223-230
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:Patients treated for pediatric malignancy are at high risk of parenterally transmittedviral hepatitis.Objectives:To detect the seroprevalence of hepatitis B and C viral infections in children withAcute Lymphoblastic Leukemia & identify some variables that could affect itsprevalence in these patients.Patients and Methods:One hundred fifty pediatric acute lymphoblastic leukemia patients, presented toChildren Welfare Teaching Hospital, Baghdad, during the period from March 11th2007 to July 31st 2007 were enrolled in this study; they were 103 males, 47 females,aged (2.25 months- 16 years). Sera of these patients were investigated for hepatitismarkers including HBsAg and Anti HCV antibody.ResultsThe majority of patients were from Baghdad 104 (69.33%). Almost all childrenreceived 3 doses of hepatitis B vaccine according to the national Iraqi vaccinationschedule & 111 (74%) of them received another course of vaccination during theiradmission to the oncology unit at CWTH.Screening for hepatitis B virus infection was positive in 54 (36%) of cases while forhepatitis C virus infection was positive in 4 (3.25%) of cases.ConclusionMultiple blood transfusions and prolonged duration of observation of patients showedsignificant statistical impact on the incidence of HBV infection.


Article
LANGERHANS CELL HISTIOCYTOSIS IN CHILDREN

Authors: KHALID Q. ABD --- SALMA A. AL-HADAD --- MAZIN F. AL-JADIRY
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2008 Volume: 50 Issue: 3 Pages: 296-302
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of histiocytes
encompasses a wide clinical spectrum, ranging from a benign localized disease to acute
generalized disease with fatal outcome.
Objectives: to retrospectively evaluate clinical characteristics at diagnosis and outcome of
patients with Langerhans cell histiocytosis.
Patients and methods: A retrospective analysis of data on 21 children with Langerhans cell
histiocytosis followed at Oncology unit, Children Welfare Teaching Hospital, Medical City,
Baghdad, between 1999 and 2006.
Results : The age at time of diagnosis of LCH ranged from 3 months to 9 years, with a median of
22 months, and male to female ratio was 1:1.1. The duration of the onset of the disease before
diagnosis ranged from 1month to1 year. Bone lesions, skin lesions and LAP were the common
presenting features. Skull was the major site of lytic lesions 10(47.6%) patients. Tissue biopsy
and/or aspiration were the main diagnostic procedures. Twenty patients treated by different
combinations of chemotherapy. Ten patients survived (50%), and the mean time of follow up
was 28 months.
Conclusion : The study showed a relatively high incidence of advanced (III and IV) stages of
disease 12 patients (57.1 %) with subsequent poor outcome and survival.
Recommendation : Long term follow-up by a multidisciplinary care team is required


Article
Serological and molecular detection of parvovirus b19 in children with acute lymphoblastic leukemia

Authors: Mazin F. Al-Jadiry --- Shatha F. Abdullah شذى فاروق --- Iqbal M. Abdullah
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2014 Volume: 56 Issue: 3 Pages: 318-321
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Human parvovirus B19 (B19V) is the only human pathogenic parvovirus, It is highly erythrotropic and preferentially replicates in erythroid progenitor cells (EPCs). Recently the effects of B19 infection have been well studied in children with acute lymphoblastic leukemia (ALL). Objective: To detect parvovirus B19 among children with ALL.Methods: A cross sectional study involved forty five patients with ALL (21 patients were newly diagnosed ALL and 24 children who underwent chemotherapy) who were attending department of oncology in Children's Welfare Teaching Hospital in Baghdad Medical City between December 2012 and April 2013, compared to forty five of apparently healthy children as a control group, age and sex were matched. A serological and molecular detection of parvovirus B19 were done using enzyme linked immunosorbant assay (ELISA) and Real-time PCR.Results: B19-IgM, IgG and DNA were detected in study cases as (15.6%, 40% and 13.3%) compared to control group (4.4%, 13 % and 0%) respectively. B19-IgG and B19-IgM were detected in newly diagnosed cases in (41.7% and 19.05%) as well as in (38.1% and 12. 5%) of cases on chemotherapy respectively, all cases with B19-DNA signals were underwent chemotherapy (25%) with mean viral load of (36x104 copies/ml).Conclusion: children who suffering from ALL are at increased risk of B19 infection. Notable percentage of persistent B19 infection was recorded among children with ALL who are receiving ongoing treatment.Key words: parvovirus B19, acute lymphoblastic leukemia (ALL), real time PCR.


Article
Retinoblastoma in Iraqi Children, the Experience of Children Welfare Teaching Hospital
سرطان شبكية العين عند الاطفال العراقيين، تجربة مستشفى حماية الأطفال التعليمي

Authors: Rasim M. Al-Jumaily راسم الجميلي --- Salma A. Al-Hadad سلمى الحداد --- Mazin F. Al-Jadiry مازن البلداوي --- Areej Emad Kadhom أريج عماد كاظم
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2019 Volume: 61 Issue: 2 Pages: 50-54
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Retinoblastoma is the most common intraocular tumor affecting young children. Objectives: To review the clinical presentation and treatment outcome of retinoblastoma in children treated at the Children Welfare Teaching Hospital, Baghdad.Patients and Methods: A review of 32 children with retinoblastoma, diagnosed and treated at the Oncology Unit, Children Welfare Teaching Hospital, Medical City, Baghdad from 1999 to 2006.Results: Among 32 patients, 56.25% were males and 43.75% were females with a median age of 34.5 months. Unilateral disease was observed in 19 patients. Leukocoria was the most common presenting feature. Advanced stages were predominant in half of the patients. Chemotherapy following eye enucleation was the mainstay of treatment. The disease-free survival was 23.33% while the mortality rate was 26.67%.Conclusions: This single center study reported a poor outcome and a low disease-free survival due to high frequency of advanced stages and abandoning treatment by the parents.

الخلفية: : سرطان شبكية العين هو ورم العين الأكثر شيوعاً الذي يصيب الاطفال الصغار.الأهداف: مراجعة الاعراض السريرية واستجابة سرطان شبكية العين عند الأطفال الذين عولجوا في مستشفى حماية الأطفال التعليمي في بغداد. المرضى والطرق: أجريت دراسة مراجعة على 32 طفل عراقي مصاب بسرطان شبكية العين، تم تشخيصهم وعلاجهم في وحدة الامراض السرطانية في مستشفى حماية الأطفال التعليمي في مدينة الطب في بغداد في الفترة من 1999 الى 2006.النتائج: من بين 32 مريضا ، كان 56.25 ٪ من المرضى ذكوراً و 43.75 ٪ إناثاً مع متوسط عمر يبلغ 34.5 شهراً. قد لوحظ المرض في جانب واحد في 19 مريضا، وكان الانعكاس الابيض للبؤبؤ أكثر الاعراض السريرية شيوعاً وكانت المراحل المتقدمة للمرض هي السائدة في 33.4% من المرضى. كان العلاج الكيميائي الذي يعقب الاستئصال الجراحي للعين هو الدعامة الأساسية للعلاج. بلغت نسبة البقاء على قيد الحياة خالياً من المرض 23.33٪ في حين كانت نسبة الوفيات 26.67٪. الاستنتاجات: أظهرت دراسة المركز الواحد انخفاض نسبة البقاء على قيد الحياة خالياً من المرض بسبب ارتفاع نسبة تشخيص المرض في مراحل متقدمة و والتخلي عن العلاج من قبل الوالدين.

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