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Article
Chilblains in Iraqi patients in Hilla City (Clinical study)

Author: Mohammed K. Al-Hattab
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2008 Volume: 2 no.4, 5 Issue: 3 Pages: 336-344
Publisher: Kerbala University جامعة كربلاء

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Abstract

chilblain is a major medical problem in Iraqi population in winter time and the purpose ofthis study was to determine the clinical patterns of involvement in patients at Hilla city.A total of 60 patients with chilblains were assessed in the department of dermatology inMerjan teaching hospital during the cold months between January 2007 to February 2008. Theirages ranged from 1.5-70 years (mean ± SD, 22.6±13.6 years).The duration of the disease rangedfrom 2-90 days (mean ±SD, 24.5±20.7 days). There were 40 females (66.6%) and 20 males(33.4٪) with a sex ratio of 2:1. The majority of patients were between 11-30 years of age (71.6%)and females forming about 79.5%, female: male ratio was about 3.8:1.All patients were presented in January and February and the attacks in majority of patientsstarted in December (20 patients) and January (30 patients) forming about 83.3%. Family historyin close relatives were positive in 14 patients (23.3 %).Thirty one patients developed similarattacks at previous winters (51.6%). Numbers of previous attack of perniosis / winter were from 1-215 attacks.Associated systemic and dermatological diseases were: hypertension (3.3%), diabetesmellitus (3.3%), systemic lupus erythematosus (3.3%), pregnancy (3.3%), atopic dermatitis(3.3%), allergic rhinitis (3.3%), anemia (1.6%) and hand eczema (1.6%).Regarding the sites of the lesions, chilblains commonly affected either hands alone (48.3%),feet alone (33.3%) and to a lesser extent both hands and feet (18.3 % ). The feet alone werecommonly affected in females (88.2%) while the hands alone in males (60 %). Hands and feetwere affected together most commonly in females (91%).Ears, nose and buttock were also affected(1.6%) for each.Clinically, the types of lesions in patients with chilblains were: erythematous cyanoticswelling (81.6%), some with diffuse welling sausage - like (13.3%),erythema multiforme –likepicture with target lesions (20 %), purpuric rash (15 %),ulcerated lesions (11.6%), eczematizationwith fissuring (11.6%),blisters or vesicles (6.6%),dusky red papules (6.6%), lupus erythematosus –like rash on dorsum of the hands (5%) and nodules (3.3%).In Iraq, chilblains clinically could be presented in a form of erythema multiforme-like,erythema nodosum –like, lupus erythematosus-like or sausage-like swelling with cold fingers andtoes, pain, tenderness and itching.

مرض تشرين ( الشرث ) عند المرضى العراقيين في مدينة الحلة, دراسة سريريه:70 سنة أي بمعدل 22.6 سنة. وجد - تمت دراسة 60 حالة من المرضى المصابين بمرض تشرين تتراوح أعمارهم بين 1.5ب

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Article
Possible Adverse Cutaneous Effects in Patients Taking Imatinib Mesylate ( Gleevec ) in Treatment of Chronic Myeloid Leukemia (CML) and Gastro Intestinal Stromal Tumors ( GISTs) at Hilla City

Author: Mohammed K. AL – Hattab
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2013 Volume: 10 Issue: 3 Pages: 537-546
Publisher: Babylon University جامعة بابل

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Abstract

Imatinib mesylate (gleevec ) is a drug that used to treat certain cancers. Sixty – two patients with CMLs and GLSTs received gleevec capsules as a chemotherapeutic treatment were studied.. These patients developed one of the following cutaneous diseases mainly as an adverse cutaneous reaction to gleevec therapy for malignant diseases or as an association with it. Melasma ( 19.3% ), Eczema or dermatitis ( 14.5%), Acne – form rash (12.9%), Folliculitis (9.7%), Erythema nodosum (6.4%), Erythema multiforme (4.8%), Pruritus ( 4.8%), Pityriasis rosea( 3.2%), Psoriasis ( 3.2%), Chronic urticaria ( 3.2%), Xerosis of skin (3.2%), Vitiligo( 1.6%), Beau's lines of nails (1.6%), Cheilitis (1.6%), Common warts (1.6%), Herpes zoster (1.6%), Tinea incognito (1.6%),Lichenification (1.6%), Prurigo simplex (1.6%) and Palmar keratoderma (1.6%).From this study, gleevec was reported for the first time to cause or trigger the following adverse effects: seborrheic dermatitis , acne – form rash, classical erythema multiforme, atypical pityriasis rosea ( pityriasis circinate et marginate of widale) and acquired ichthyosis. Also this work, was the first one showed the association between gleevec and induction of erythema nodosum in Iraq. Gleevec was one of the considerable causes of melasma in Iraq.

التأثيرات الجانبية المحتملة لعقار الأيماتنيب ( الكليفيك ) المستخدم في علاج مرضى سرطان الدم وأورام الجهاز الهضمي في مدينة الحلة . تم دراسة 62 حالة من مرضى سرطان الدم وأورام الجهاز الهضمي المتعاطين لعقار الكليفيك والمحالين من مركز الأورام في مستشفى مرجان التعليمي إلى قسم الأمراض الجلدية والتناسلية في نفس المستشفى حيث كانوا يعانون من أمراض جلدية متنوعة ناتجة كتأثيرات جانبية لهذا العقار.تراوحت أعمار المرضى ما بين 21 – 72 سنة وكان عدد الذكور 38 (61.3% ) وعدد الإناث 24 ( 38.7% ). كان عدد المصابين بسرطان الدم 48 (77.4%) واورام الجهاز الهضمي 14 (22.6%). تراوحت فترة العلاج بعقار الكليفيك ما بين 2 شهر – 4 سنوات وجرعة العقار تراوحت ما بين 400 – 800 ملغم في اليوم. أثبتت الدراسة عن حصول بعض الأعراض الجانبية المؤثرة على الجلد نتيجة أخذ عقار الكليفيك ولأول مرة حيث لم تثبت مسبقاً في دراسات سابقة وهي كالاتي: التهاب البشرة الدهني ، الطفح الشبيه بحب الشباب ، الاحمرارية المتعددة الاشكال التقليدية ، النخالية الوردية ، داء السمكة المكتسب، وكذلك أثبتت الدراسة عن ارتباط عقار الكليفيك بالإصابة بالاحمرارية العُقديّة ولأول مرة في العراق ، ويعتبر العقار سبب مهم في الاصابة بمرض الكلف في العراق. كذلك أثبتت الدراسة ارتباط العقار بأمراض جلدية أخرى كالتهاب بصيلات الشعر، الحكة ، الصدفية ، جفاف الجلد ، وكذلك تقرن باطن الكف أو القدم.


Article
Non – melanoma skin cancers of the face A clinical and pathological study

Authors: Mohammed K. Al-Hattab --- Hadi Al-Musawi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2008 Volume: 5 Issue: 2 Pages: 223-241
Publisher: Babylon University جامعة بابل

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Abstract

Non – melanoma skin cancer like basal cell carcinoma ( BCC ) and squamous cell carcinoma ( SCC ) are not an uncommon skin diseases in Iraqi patients, so this study was conducted to shed light on various clinical and histopathological aspects of these cancers affecting the face, at Hilla city. A total of 50 patients with non – melanoma skin cancers was seen. Their ages ranged between 10 – 85 years ( mean ± SD, 54.9 ± 16.1 years ), while their ages of onset ranged between 7 – 80 years ( mean ± SD, 52.4 ± 15.5 years ). The duration of the disease ranged from 1-7 years ( mean ± SD, 2.9 ± 1.5 years ). There were 28 males ( 56 ٪ ) and 22 females ( 44 ٪ ) with a sex ratio of 1.3 : 1. Twenty – nine patients with basal cell carcinomas were seen ( 58٪ ). There ages ranged between 30 – 85 years ( mean ± SD 58.4 ± 13.9 years ), while their ages of onset between 29 – 80 years ( mean ± SD, 50.7 ± 18.4 years ). The duration of the disease ranged between 1-7years ( mean ± SD, 3.4 ± 1.4 years ). There were 16 males ( 55 ٪ ) and 13 females ( 45 ٪ ) with a sex ratio of 1.2 : 1. The clinical types of BCCs on the face were : nodulo – ulcerative ( 38 ٪ ), pigmented ( 14 ٪ ), morpheaform ( 4 ٪ ) and cystic ( 2 ٪ ). The sites of involvement of BCCs on the face were : nose ( 16 ٪ ), cheeks ( 14 ٪ ), forehead ( 12 ٪ ), inner canthi of eyes ( 6 ٪ ), upper vermilion lip ( 4 ٪ ), retroauricular ( 4 ٪ ) and inside the auricle of left ear ( 2 ٪ ). The pathological types of BCCs were : nodular ( 40 ٪ ), pigmented ( 14 ٪ ) and morpheaform ( 4 ٪ ). The clinical types of BCCs, the sites of involvement on the face and the pathological features were comparable to what has been reported. Eighteen patient with squamous cell carcinomas were seen ( 36 ٪ ). Their ages ranged between 10 – 70 years ( mean ± SD, 48 ± 19 years ) while their ages of onset between 7 – 68 years ( mean ± SD, 54.6 ± 10.6 years ). The duration of the disease ranged between 1 – 3 years ( mean ± SD 1.5 ± 1.6 years ). There were 9 males ( 50 ٪ ) and 9 females ( 50 ٪ ) with a sex ratio of 1 : 1. The sites of involvement of SCCs on the face were : cheeks ( 16 ٪ ), lower lip ( 8 ٪ ), upper lip (4 ٪ ), forehead ( 4 ٪ ), nose ( 2 ٪ ) and pinna of left ear ( 2 ٪ ). The pathological types of SCCs were : well differentiated ( 16 ٪ ), moderately well differentiated ( 18 ٪ ) and poorly differentiated ( 2 ٪ ). Theclinical, histopathological and sites of involvement were similar to what has been reported. The study prsented the first reported case of SCC arising from a scar of localized atrophic discoid lupus erythematosus on the upper lip, in Iraq. Other non – melanoma skin cancers of the face reported in the study were : basosquamous ( 2 ٪ ), mycosis fungoides ( 2 ٪ ) and kaposi's sarcoma ( 2 ٪ ).

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Article
Study of Serum Leptin and Lipid Profile Concentration in Psoriatic Patients in Hilla - Iraq

Authors: Mohammed K. Al-Hattab --- Moaed E. Al-Gazally --- Radwan A. Al-Asadi
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2011 Volume: 4 no 2 Issue: 10 Pages: 1109-1116
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: To study the role of biochemical markers in sera of psoriatic patients.Aim: Evaluation and study of the correlation between lipid profiles and Leptin in sera of psoriatic patients in Hilla province – Iraq.Patients and Methods: The study was conducted on sixty psoriatic patients and thirty apparently healthy persons were taken as control group. Blood collected from the clinic of dermatology in Merjan Teaching Hospital and from the consultative center for allergy and asthma in Hilla city / Iraq. Sera obtained from the blood were used to determine the effect of psoriasis on leptin, total cholesterol, high density lipoprotein (HDL-C), triglycerides (TGs), very low density lipoprotein (VLDL), and low density lipoprotein cholesterol (LDL-C) concentration.Results and Discussion: The results of the present study showed (significant increase in leptin, total cholesterol, triglycerides, very low density lipoprotein and low density lipoprotein cholesterol concentration), significant decrease in high density lipoprotein cholesterol in sera of psoriasis group compared to control group, significant increase in leptin concentration in sera of psoriasis females than males, significant increase in leptin concentration in sera of psoriasis patients as increase BMI (body mass index).

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