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DOWN'S SYNDROME A NEW MATERNAL IRAQI RISK
متلازمة داون : خطر جديد للنساء العراقيات.

Author: Mohammed Sh. Tawfik محمد شفيق توفيق
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2010 Volume: 8 Issue: 3 Pages: 55-59
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: The occurrence of Down's syndrome is usually associated with advancing maternal age and increased parity.Objectives: This study explores the risk factor associated with the occurrence of Down's syndrome for different age groups. Methods: Blood sample from suspected Down's syndrome babies were prepared for chromosomal preparation. A hundred and fifty four blood samples from patients suspected of being Down's syndrome baby came with variable features which raise the suspicion of being Down's.Results: The study groups were 65 male and 89 female. Seventy seven (77) were the first member of the family, 68 were born for young mothers with an age between 15-34 years. Only nine were born for old mothers aged between 35-43 years. Seventy three were members of the family other than the first. Twenty six were born for mothers aged between 35-43 years, while the other 47 were born for mothers aged between 15-34 years. Chromosomal study for 4 cases revealed normal chromosomal findings.Conclusion: This study may show that young Iraqi mothers (under 35 year) carry high risk of having down's baby both in multi as well as primigravida.Key words: Down's syndrome, trisomy, primigravida, multigravida, Chromosome.

خلفية الدراسة: إن متلازمة داون محتملة الحدوث في الأطفال الذين يولدون لنساء حوامل متقدمات بالسن او نساء لديهن عدد كثير من الولادات. هدف الدراسة: تحديد مدى تأثير عامل العمر لنساء الحوامل في حدوث متلازمة داون .المرضى وطريقة العمل: استخدم الفحص الكروموسومي لمجموع 154 طفل أحيلوا من أطباء اختصاص كونهم يحملون صفات تدل على احتماليه كونهم مصابين بمتلازمة داون.النتائج: تضاعف الكروموسوم رقم 21 كانت النتيجة التي ظهرت لـ 150 طفل بينما أظهرت النتائج وجود 4 حالات فقط من الأطفال المحالين يحملون 46 كروموسوم بواقع ( 3 حالات يحملون 46xx) بينما الحالة الرابعة أظهرت وجود (46xy) .الاستنتاج: بينت الدراسة بأن تقدم العمر للنساء الحوامل قد لا يلعب دور بزيادة احتمالية حدوث متلازمة داون. مفتاح الكلمات: متلازمة داون , فحص كروموسوم.

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