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EDITORIAL: GENETICS: THE ROAD TO ANCESTORS

Author: Muthanna A Al-Kaabi مثنى عبد الامير الكعبي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2011 Volume: 9 Issue: 3 Pages: 193-194
Publisher: Al-Nahrain University جامعة النهرين

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IMMUNOHISTOCHEMICAL LOCALIZATION OF HNF4Α IN THE CHOROID PLEXUS OF THE RABBIT VENTRICLES WITH CLINICAL IMPLICATION

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Background:The choroid plexuses are composed of highly differentiated epithelial cells in with connective tissue and permeable capillaries among them. These cells connected by tight junction to form the blood –CSF-barrier that plays important role in protection of CNS. HNF4α is transcription factor of many drugs transporter proteins and known as nuclear subfamily 2 group alpha encoded by HNF4 alpha gene can be found in the liver, pancreas, intestine, brain and recently in epithelial cell of choroid plexuses.Objectives:To evaluation the HNF4α intensity and localization of the choroid plexus in the lateral and forth ventricles of the rabbit.Methods:Choroid plexuses of lateral and forth ventricles of 30 adult male rabbits were studied by morphological and immunohistochemical evaluation of HNF4α in theses ventricles that play role in regulation of drugs transporters and drugs metabolism in B-CSF-B.Results: Histological method showed little different features by subjective examination between various localizations of the choroid plexuses. The immunohistochemical activity of HNF4α was different between lateral and forth ventricle where the IHC positivity is more in the lateral ventricle (0.067±0.029) than forth ventricle (0.032 ±0.018) and this results is statistically significant.Conclusion:The choroidal cells of lateral ventricle showed more IHC activity of HNF4α and might indicate targeting of many drug transporters proteins, metabolites and eliminate of toxic compounds from brain tissues.Key word:Choroid plexuses, HNF4α in lateral ventricle, drug transporter across the blood brain barrier.


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LOCALIZATION OF TIGHT JUNCTIONS BETWEEN TANYCYTE-LIKE CELLS OF THE SULCUS MEDIANUS ORGANUM IN RAT BRAIN

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Background: Tanycytes are highly specialized ependymal cells (ECs) that line the regions of circumventricular organs (CVOs) where the blood-brain barrier is absent. These cells show tight junctions (TJs) that form a blood–cerebrospinal fluid barrier at the regions of these organs, thus modulating the transport mechanisms between the cerebrospinal fluid and the brain capillaries. Objective:To investigate the presence of TJs between ECs of the sulcus medianus organ (SMO) in the floor of the 4th ventricle in comparison to the region of the median eminence (ME) of the hypothalamus, a known CVO in the brain.Methods:Ten adult male rats (Rattus Norvegicus Albinus) aged 3-6 months were used to study the general histological morphology of ECs at the SMO and ME regions by H. and E. stain, and to explore the immunofluorescence labelling of these cells for TJs using anti-ZO1 FITC.Results:The ECs were arranged in 2-3 layers in the depth of the median sulcus (MS) at the SMO region as seen with H. and E. stain. Immunofluorescent labelling with anti-ZO1 FITC revealed the presence of TJs between ECs of the SMO in a way similar to that reported between tanycytes of the ME.Conclusion:The SMO contained tanycytes or tanycyte-like cells that exhibited TJ complexes. This unique cell population added a strong evidence for the presence of a CVO in the rostral part of the MS to link CVOs on both sides of the cerebral aqueduct.Keywords: Tanycytes, circumventricular organs, sulcus medianus organum, tight junctions

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