research centers


Search results: Found 3

Listing 1 - 3 of 3
Sort by

Article
Histological evaluation of osseointegration around titanium implants in thyroidectomized rabbits (experimental study).

Authors: Zaid M. Ali زيد علي --- Nada M. H. Al-Ghaban ندى الغبان
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 2 Pages: 75-79
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Thyroid hormones are essential for linear growth and peak bone mass acquisition. Hypothyroidismoccurs when the thyroid gland produces less than the normal amount of thyroid hormones. The present study wascarried out to evaluate the effect of hypothyroidism on osseointegration around the titanium implants screwed inrabbit's tibia.Materials and methods :Fifty four machined surface Iraqi implants were inserted in 27 male rabbits (2implants in eachrabbit's tibia ).Eighteen of these rabbits were subjected to near total thyroidectomy to induce hypothyroidism threeweeks before implantation surgery. While the remaining 9 rabbits were remain as a control group. Blood sample wastaken from each animal at the beginning of this study in order to find the normal range of T3,T4,and TSH .And anotherblood sample was taken for experimental groups to find the levels of T3,T4,and TSH three weeks after thyroidectomyin order to assess the hypothyroidism status .After 2, 4, 6 weeks after implant surgery (6rabbits from experimentalgroup and 3rabbits from the control group) were sacrificed. In the day of scarification, one of the screws wasunscrewed with a torque meter, and the peak torque required to shear off the implant was recorded. Then thedecalcified sections of the bone around the implants were studied histologically and histomorphometrically .The eyepiece reticule was used for morphometrical studies, which were includes: number of osteocytes, number ofosteoblasts, thickness and number of bone trabeculae, and thread widthResults:The results showed that hypothyroid rabbits had delay in osseointegration, bone formation and maturationaround implants in almost all rabbits in experimental groups. While the rabbits in the control groups showedimprovement in osseointegration around titanium implant. Removal torque test illustrated higher torque test value incontrol animals than in experimental one. Moreover, there were increases in torque test values in both groups withtime. Biochemical serum analysis revealed a decrease in T3, T4, and increase TSH levels in experimental animals.Conclusion: It can be concluded that there were low bone quality with a delay in bone healing around titaniumimplants in hypothyroidied rabbits compared with healthy one.


Article
The effects of bisphosphonate administration on teeth development and growth of the jaw bones in neonatal rats (histological and immunohistochemical study)

Authors: Suhail Labeeb Hasoon سهيل لبيب حسون --- Nada M. H. Al-Ghaban ندى الغبان
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: special issue 1 Pages: 77-82
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Bisphosphonates are potent inhibitors of osteoclastic bone resorption and widely used for the treatmentof osteoporosis, and osteogenesis imperfecta in children. Clinical and experimental studies have demonstrated thatBisphosphonates delay or inhibit tooth eruption. This study tries to focus on the effect of bisphosphonate on teethdevelopment and jaw bones growth.Materials and methods: The present study includes 65 neonatal rats during lactation period from 15 Albino Wister ratsmother. Alendronate (one type of Bisphosphonates) was administrated orally (15 mg/kg) into 10 pregnant rats twotimes a week, while other 5 rats regard as control. Then the neonatal rats sacrificed in I, 6, 11, 16 and 21 days. Thelower first molar were examined histologically and immunohistochemical for amelogenin expression. Biochemicalserum analysis for calcium and alkaline phosphatase level were down for 11, 16 and 21days group. All histological,immunohistochemical, and biochemical results are compare with their controls.Results: The histological results illustrate retardation in tooth and root development, impairment in maturation ofenamel and retardation in tooth eruption of the first molar tooth germ in alendronate treated neonatal rats than theircontrols. Also immunoreactivity for amelogenin at early stages of tooth development was somewhat more intense inexperimental group than that in their controls .Moreover, calcium and alkaline phosphatase serum levels inexperimental rats are less than that of their controls.Conclusion: This study concludes that treatment with alendronate during tooth development has the potential toinhibit tooth eruption, impair tooth formation, may induce some types of dental abnormalities, and increase thebone trabecule thickness by decreasing osteoclastic activity.


Article
Histological and histomorphometric studies of the effects of hyaluronic acid on osseointegration of titanium implant in rabbits

Authors: Mohammad Hasan Mohammad محمد حسن محمد --- Nada M. H. Al-Ghaban ندى الغبان
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2018 Volume: 30 Issue: 2 Pages: 10-16
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: One of the unique prosthesis for tooth or teeth replacement is the dental implant. Our attempt is using a biomaterial system that is easily obtained and applicable and has the ability to provoke osteoinductive growth factor to enhance bone formation at the site of application. One of these natural polymers is hyaluronic acid. Material and methods: Sixty machined surface implants from commercially pure titanium rod inserted in thirty NewZealand rabbits. Two implants placed in both tibia of each rabbit. The animals scarified at 1, 2 and 4 weeks after implantation (10 rabbits for each interval). For all of animals the right tibia’s implant was control (uncoated) and the left one was experimental (coated with 0.1ml Hyaluronic acid gel). All sections have been stained with Haematoxylin and Eosin then they were histologically examined and assessed for histomorphometric analysis for counting of bone cells (osteoblast, osteocyte and osteoclast), cortical bone thickness, trabecular width, thread width and marrow space star volume (V*).Results: Histological findings for hyaluronic acid- coated titanium implant revealed an earlier bone formation, mineralization and maturation than that in control groups. Histomorphometric analysis for all bone parameters that examined in this study, showed highly significant difference between control and experimental groups in all healing intervals.Conclusion: Commercially pure titanium endosseous implants coated with hyaluronic acid may be osteocoductive thus accelerating healing process and enhancing osseointegration

Listing 1 - 3 of 3
Sort by
Narrow your search

Resource type

article (3)


Language

English (3)


Year
From To Submit

2018 (1)

2013 (1)

2012 (1)