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Article
The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients

Authors: Khalida M .Al-Moussawy --- Nahla Ghanim --- Wifaq M. AL-Wattar
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 111-115
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Tinea versicolor is a common dermatological problem ,world wide distribution ,caused by a dimorphic fungus called Malassezia furfur ,it live normally on skin as a commensal .Many factors play a role in the etiology of TV among these could be the disturbed immune systemwhich may be related to the ability of TV alter the immune system by a process calledImmunomodulation leading to subsequent infection.Immuno-inflammatory activity mediated by different cytokines could have a role in the etiologyof TV.Objective: To evaluate the serum level of the inflammatory cytokines ,IL-4andIL-8,in patients withTV as compared to immunocompramized patients and healthy groups.Patients and methods: This study enrolled 50 total patients, 15 of them were as patients controlgroup who were immunocompramized with evident skin lesion ,to be compared serologically with 15patients who had TV and normal immunity, the control group composed of20 healthy volunteers.Using ELISA test technique the following tests were done :detection of IL-4 and IL-8 in the sera ofall groups.Results and discussion: The statistical differences in the rate of detectable IL-4 level between TVand healthy control p< 0.001,while the difference was a highly significant between the healthycontrol and immunocompramized patients with TV,P<0.00338.The difference between twodiseased groups was(p< 0.219)which is non significant , when p<0. 05 was considered significant.IL-8 the results of our study showed a significant difference between the healthy control and thepatients with tinea versicolor, p-value was( 0.05).In this study there was a nice findings by which the difference between the healthy control and theimmunocompramized patients was highly significant as ,p<0.005.Conclusion :The genus Malassezia is an immunological paradox. In some circumstances, it actsas an adjuvant, activates the complement cascade, and elicits both cellular and humoral immuneresponses in healthy individuals, among which IL8 and IL-4 were notably increased . In contrast,it also seems to have the ability not only to evade the immune system but actually to suppress theresponse directed against


Article
Evaluation the Levels of IFN-Gamma , IL-10 and Concentration of Zn in Children with Visceral Leishmaniasis

Authors: Mais N. Kamil --- Sabah Al-Najar --- Nahla Ghanim
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: 4 Pages: 504-510
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: Visceral Leishmaniasis (VL) is a systemic infection of the reticulo- endothelial system that could affect on immune system and biochemical parameters like the concentration of trace elements which may be significantly changed . OBJECTIVE: Evaluating the level of cytokines (INF- γ ,IL-10) and concentration of Zn in Visceral Leishmaniasis in children after diagnosis . PATIENTS AND METHODS: A total of (98) child their ages rang (6m-5y) were attending to the Central Public Health Laboratory and Teaching Laboratories of Medical City suspected to be infected with kala-azar, the diagnosis was done by both IFAT technique and Rapid Kala-azar (r-K39) detecting test and evaluating the level of cytokines (INF- γ, IL-10) by ELISA and concentration of trace element ( Zn ) by Atomic Absorption Technique . RESULTS : The dipstick test ( r-K39) showed a high sensitivity of (92.1%) compared to IFAT (73.6%) with a specificity of 100% for both tests. Serum samples of 56 child with positive results in IFAT and rK39 test were used for the investigation of IL-10, IFN-γ. The mean levels of IL-10 (80.207±77.54 Pg/ml) and IFN- γ (5.426±4.599 IU/ml) were highly significant increased in patients compared to healthy controls .The mean level of serum Zn (69.71±7.97μg/dl) was significantly low in VL patients compared to healthy controls .CONCLUSION : This study showed that the ( r-K39) dipstick test could be more sensitive than IFAT technique in the diagnosis of VL with a specificity of 100 % for both test according to clinical diagnosis. Both IFN-γ & IL-10 were significantly increased in VL patients as compared to controls group. The concentration of Zinc was significantly lower in VL patients than healthy controls.


Article
Evaluation of the levels of IFN-gamma, IL-10 and Copper in children with Visceral Leishmaniasis
تقييم مستويات الانترفيرون-كاما و الانترلوكين- 10 وتركيز النحاس في مصول دم الاطفال المصابيين باللشمانيا الاحشائية

Authors: Mais N. kamil ميس نبيل --- Sabah Al-Najar صباح النجار --- Nahla Ghanim نهلة غانم
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2014 Volume: 56 Issue: 1 Pages: 90-94
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Visceral Leishmaniasis( VL ) is a systemic infection of the reticulo- endothelial system that could affect the immune system and biochemical parameters like the concentration of Copper which may be significantly hanged . Objective: The study aims to evaluate the level of cytokines (INF- γ ,IL-10 ) and trace element (Cu ) in Visceral Leishmaniasis in children after diagnosis . patients and Methods: A total of 98 children, whose their ages ranged (6 menthes -5 years) were attending the Central Public Health Laboratory and Teaching Laboratories of Medical City, who were suspected to be infected with kala- azar, who were diagnosed by both IFAT technique and Rapid Kala-azar (r-K39) detecting test and trying to evaluate the level of cytokines (INF- γ , IL-10) by ELISA and concentration of ( Cu ) by Atomic Absorption Technique Results: The dipstick test ( r-K39) showed a high sensitivity of (92.1%) compared to IFAT (73.6%) with a specificity of 100% for both tests. Serum samples of 56 child with positive results in IFAT and rK39 test were used for the investigation of IL-10, IFN-γ. The mean levels of IL-10 (80.207±77.54 Pg/ml) and IFN- γ (5.426±4.599 IU/ml) were highly significant increased in patients compared to healthy controls. The mean level of serum Cu (171.54±10.37 μg/dl) in VL patients.Conclusions: This study showed that the ( r-K39) dipstick test could be more sensitive than IFAT technique in the diagnosis of VL with a specificity of 100 % for both test according to clinical diagnosis. Both IFN-γ & IL-10 were significantly increased in VL patients as compared to controls group. Copper concentration was significantly higher in VL patients than healthy controls.Keyword: Visceral Leishmaniasis , IFN-gamma , IL-10, trace element ( Cu ).

الخلاصة :ــخلفية الدراسة: اللشمانيا الاحشائية مرض يصيب الجهاز الطلائي الشبكي البطاني يؤثر هذا المرض على النظام المناعي لجسم الانسان كما انه قد يعمل على احداث تغيير واضح في تراكيز ومستويات بعض المعادن الضئيلة كالنحاس . الاهداف: تقييم مستويات وتراكيز كل من IL-10 و γ IFN- وCu للاطفال المصابين باللشمانيا الاحشائية بعد تشخيص اصابتهم بالمرض باستخدام كل من اختبار المستضد الماشوب -39 و تقنية التالق المناعي غير المباشر . طرق البحث : تضمن البحث 98 طفل تتراوح اعمارهم بين ( 6 اشهر و 5 سنوات )، 22 منهم راجعوا الى مستشفى الجراحات التخصصية و 76 راجعوا الى كل من مختبرات الصحة العامة المركزية والمختبرات التعليمية لمدينة الطب , استخدمت تقنية الـIFAT والـ r-K39 DIPSTICK لتشخيص اصابتهم باللشمانيا الاحشائية و تقنية الـ ELISA لقياس تراكيز كل من IL-10 و γIFN- بالاضافة لتقنية (Atomic Absorption Specrtophotometer)لقياس نسبة ال Cu . النتائج :اظهرت نتائج البحث ان حساسية ودقة اختبار المستضد الماشوب -39 كانت (92.1% ) بالمقارنة مع اختبار التالق المناعي غير المباشر ( 73.6 %) واظهرت كلا الطريقتين اعطت خصوصية 100%. لوحظ ارتفاع معدلات كل من الانترفيرون –كاما والانترلوكين -10 في مصول دم الاطفال المصابين باللشمانيا حيث كان معدل الانترلوكين -10 ( 80.207 ± 77.54 بيكوغرام / مل ) والانترفيرون- كاما ( 5.426 ± 4.599 وحدة دولية / مل) مقارنتا بمعدلاتهما في مصول دم الاطفال اللاصحاء . عند قياس معدل النحاس في مصول دم الاطفال المصابين باللشمانيا كانت مرتفعة مقارنتا بالاطفال الاصحاء ( 171.54 ±10.37 مايكرو غرام /ديسيلتر) . الاستنتاج : اظهرت الدراسة اعلاه ان اختبار المستضد الماشوب -39 اكثر حساسية من تقنية التالق المناعي غير المباشر مع نسبة 100% لكلا الاختبارين بالمقارنة مع الفحص السريري . من خلال هذه الدراسة تم التوصل الى ارتفاع ملحوظ في معدلات كل من الانترلوكين – 10 والانترفيرون – كاما بالنسبة للاطفال المصابين باللشمانيا الاحشائية مقارنة مع الاطفال اللاصحاء ، بالاظافة الى ارتفاع في معدلات النحاس للاطفال المصابين باللشمانيا مقارنتا مع الاطفال الاصحاء. كلمات المفتاح : اللشمانيا الاحشائية , كاما-انترفيرون , انتر لوكين -10 , معادن ضئيلة ( نحاس ) .


Article
Frequency of Anti Lactoferrin Antibodies in Patients With Systemic Lupus Erythematosus and Rheumatoid Arthriti

Authors: Nahla Ghanim Abdul–Majeed --- Mahmood Raheem Al-Rubaye --- Najeha Ahmed Ameen --- leen Khalooq Mustafa Kamil
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 4 Pages: 571-577
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: Lactoferrin is a multifunctional iron-binding protein present in several mucosal secretions as well as in secondary granules of polymorphonuclear leukocytes.Anti-Lactoferrin antibodies, which belong to antineutrophil cytoplasmic antibodies have been described in several immunomediated diseases, including Systemic Lupus Erythematosus and in patients with Rheumatoid Arthritis and others, with conflicting results regarding either their prevalence or clinical associations.OBJECTIVE:Detection of anti-Lactoferrin antibodies in Systemic Lupus Erythematosis and Rheumatoid Arthritis patients and studying its association to disease activity in comparison to healthy controls.PATIENT& METHODS :The study involved 74 Systemic Lupus Erythematosis patients, 40 Rheumatoid Arthritis patients who were referred to Immunological Department in Teaching laboratory Medical City during period of (1st of January – 31st of June) 2011 and 30 apparently healthy individual. Antinuclear antibody, complement C1q, rheumatoid factor and lactoferrin antibody were detected by enzyme-linked immunosorbent assay technique While double stranded DNA was detected by indirect immunofluorescent technique and complements (C3, C4) by single radial immune diffusion.RESULTS: Anti-lactoferrin Ab was detected in 14(18.9%) SLE patients, 4 (8.9%) Rheumatoid arthritis patients. Both C3&C4 levels were decreased significantly in Systemic lupus with positive anti lactoferrin Ab level in comparison to healthy controls( p value 0.024). In this regard Circulating immune complex was positive in 38(51.3%) systemic lupus patients only 12(31.5%) had positive lactoferrin antibody level, (p value 0.004).double stranded DNA was detected in 41(55.4%) Systemic lupus patients only 7(17.0%) of them had positive lactoferrin Ab level. Anti -Lactoferrin Abs showed neither a significant correlation with Rheumatoid factor IgG& IgM ( P value 0.159 ) nor with rheumatoid factor IgA ( P value 0. 857). CONCLUSION: Anti-lactoferrin antibodies could be detected in patients with Rheumatoid Arthritis and more often in patients with Systemic Lupus with significant correlation to decrease complements levels in comparison to healthy control.


Article
Validity of serum galectin-4(Gal-4) in diagnosis of gastric adenocarcinoma:
نفاذية الكلكتين -4 )-4 (galectin الموجود في السيرم لتشخيص الورم الغدي للمعدة :

Authors: Nahla Ghanim نهلة غانم --- Hind H. Al-Ammiri هند حميد --- Aida R. Al-Derzi عايدة رشيد
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2015 Volume: 57 Issue: 3 Pages: 236-240
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Galectin-4 is one of a b-galactosides binding proteins family that recognize a variety of glycan -containing proteins at the cell surface and are overexpressed in various tumors, including gastric cancer. Galectin-4 overexpression as well as changes in their subcellular distribution has been associated with gastric cancer progression and poor prognosis. It may provide diagnostic molecular markers for gastric cancer as well as clues for developing therapeutic targets on individual basis.Objectives : The aims of the present study were to determine the levels of GAL-4in the sera of healthy people and patients with gastric cancer and also, to investigate the validity of using GAL-4 as a specific diagnostic marker of gastric cancer.Patients and methods: twenty five gastric cancer patients were included in this study. They were among patients who attending the Endoscopy Department in Baghdad Medical City Teaching Hospital, during the period from December 2011 to July 2012. In addition, fifteen apparently healthy person were chosen as a healthy control group. For these two groups, serum level of GAL-4 using sandwich ELISA technique was carried out. Results: There was a statistically significant difference in serum level of GAL-4 among gastric adenocarcinoma patients in comparison to healthy controls (p≤0.001), using receiver operating characteristic curve (ROC) area, serum GAL-4 has high area under the curve (0.924) with a cut off value equal to or above 0.42ng/ml which was associated with the highest sensitivity (100%).Conclusions: The current study showed that serum levels of GAL-4 were significantly higher in patients with malignant gastric adenocarcinoma which may confirm a possible role of this marker in the pathogenesis of the disease, furthermore the highest sensitivity and best accuracy obtained from serum GAL-4 was by using a cut off values equal to or above 0.42ng/ml; Therefore, GAL-4 may be promising new diagnostic tools especially at early stages and among patients at high risk.Key words: galectin-4, gastric cancer, validity.

الخلاصة:الكلكتين-4 هو واحد من العائلة البروتينية المرتبطة بالكلايكوسيدات نوع بيتا و التي تتعرف على مجموعة متنوعة من البروتينات التي تحوي الكلايكان على سطح الخلية وتفرز بغزارة في الأورام المختلفة، بما في ذلك سرطان المعدة. ارتبطت غزارة الكلكتين -4 فضلا عن التغيرات في توزيعها التحت خلوية مع تطور سرطان المعدة وسوء مأّل الحالة قد توفر المعلمات الجزيئية التشخيصية للكشف عن سرطان المعدة وكذلك كموْشر لتطوير الأهداف العلاجية .الأهداف: أهداف هذه الدراسة هي تحديد مستويات كلكتين- 4 في مصل الناس الاصحاء والمرضى الذين يعانون من سرطان المعدة وأيضا للتحقيق في صحة استخدام GAL-4 كعلامة تشخيصية محددة لسرطان المعدة.طرق البحث والمرضى: أدرجت خمسة وعشرين مريضا بسرطان المعدة في هذه الدراسة وكانوا من بين المرضى الذين يحضرون قسم التنظير في مستشفى بغداد التعليمي المدينة الطبية، خلال الفترة من ديسمبر 2011 إلى يوليو 2012. وبالإضافة إلى ذلك، تم اختيار خمسة عشر شخص اصحاء كمجموعة سيطرة لهاتين المجموعتين، وأجري فحص الاليزا لقياس مستوى المصل من كلكتين -4.النتائج: كان هناك فروق ذات دلالات إحصائية في مستوى مصل الكلكتين-4 بين مرضى السرطان الغدي للمعدة بالمقارنة مع الاصحاء (p≤0.001)، وذلك باستخدام منحنى (ROC)، المصل الكلكتين-4 لديه مساحة كبيرة تحت المنحنى (0،924 ) مع قطع قيمة تساوي أو تزيد على 0.42ng / مل الذي كان مرتبطا مع اعلى الحساسية (100٪).الاستنتاج :أظهرت هذه الدراسة أن مستويات المصل من الكلكتين -4 كانت أعلى بكثير في المرضى الذين يعانون من غدية المعدة الخبيثة والتي قد تؤكد وجود دور محتمل لهذه العلامة في التسبب في المرض، علاوة على ذلك ان اعلى حساسية وأفضل دقة تم الحصول عليها من GAL-4 في المصل كان باستخدام القيم القطعيه التي تساوي أو تزيد على 0.42ng / مل. لذلك، قد يكون الكلكتين -4 من الأدوات التشخيصية الجديدة الواعدة وخاصة في المراحل المبكرة للمرض.مفتاح الكلمات:الكلكتين -4 , سرطان المعدة , نفاذية


Article
Anti Cathepsin Antibody In Systemic Lupus Erythematosus

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Abstract

Abstract:Antineutrophil cytoplasmic autoantibodies (ANCA) were found in patients withsystemic lupus erythematosus (SLE). Cathepsin G was the major target antigen. However,some ANCA-positive sera did not recognize either of them.The present study was toinvestigate the unknown target antigens of ANCA (Cathepsin G) in patients with SLE and itsrelation to the activity of the disease (ds DNA ),C1q ,C3and C4.Seventy four SLE patients referred to immunological department in teachinglaboratory medical city during period of (1st of march–31st of May) 2011 and 30 apparentlyhealthy individual as a control group were subjected to Antinuclear antibody (ANA),Cathepsin G and C1q were detected by enzyme-linked immunosorbent assay (ELISA)technique.While dsDNA was detected by indirect immunofluorescent (IIF) technique and C3,C4 by single radial immunodiffusion (SRID).The age of SLE patients ranged between (4-71) years with mean age of 32.4. Themean C1q and Cathepsin G levels were 30.14 and 9.7 respectively with significant differenceif compare it with the healthy control group. A significant result found between mean age ofSLE patients and Cathepsin Ab of a P value 0.007.The Cathepsin G antibody was found in 26 (35%) of SLE patients with a significant Pvalue (0.0001).The Cathepsin Ab were detected in 18 (43.9%) of a patients with positive ds DNAwith no significant P value 0.078. while C1q Ab were detected in 38 (51.4%) of SLE patientsand only 18 (47.4%) from them with Cathepsin Ab with statistically significant P value 0.024.Cathepsin Ab found in 19 (42.2%) of SLE patients with low level of C3 and only 6 (21.4%)of normal level of C3 with no significant P value0.076.This study showed 54(73.0%) of SLE patients had low level of C4 with no significantP value (0.15) and the Cathepsin Ab detected in 22 (40.7%) of them with no statisticallysignificant P value 0.097.A statistically significant result were found for ANA, C1q,C3,C4 and Cathepsin Abif we compare the result of SLE patients with control group, while The Cathepsin G antibodywas found statistically significant in SLE patients ,with significant relation to C1q,on otherhand no relation found with the activity of the disease (ds DNA ),C3 and C4 levels.Key Word: SLE, Cathepsin G, ds DNA, C1q, C3, C4

الخلاصة:لدى المرضى (pANCA) P وجدت الاجسام المضادة الضادة لسایتوبلازم كریات الدم البیض العدلة نوعمع ANCA المصابین بداء الذئب ألاحمراري وكان الكثبسین ج ھو المستضد المستھدف، وان نسبة علاقة مضادمستضاداتھا تحت الدراسة.الغرض من ھذه الدراسة ھو لمعرفة العلاقة بین مضاد الكثبسین ج وفعالیة المرض المتمثلة بالشریط المضاعف.(C3,C ومستوى المتمم الثالث والرابع ( 4 (dsDNA) للحامضالنووي الدیوكسي الرایبوزيخلال الفترة من الأول من آذار إلى 31 أیارعام 2011 تم تحویل 74 مریض مصابین بداء الذئب ألاحمراري إلىقسم المناعة في المختبرات التعلیمیة في دائرة مدینة الطب وتم اخذ عینات منھم مع 25 عینة من أشخاص أصحاءباستعمال تقنیة c1q ومضاد الكثبسین ج و ANA كمجموعة سیطرة، وتم أجراء فحوصات الاجسام المضادة الضادة للنواة.SRID بواسطة C و 4 C و 3 IIF بواسطة dsDNA الامتزاز المناعي المرتبط بالإنزیم (الالیزا)، وتم فحصال

Keywords

Key Word: SLE --- Cathepsin G --- ds DNA --- C1q --- C3 --- C4.


Article
THE PREVALENCE AND CLINICAL SIGNIFICANCE OF PERINUCLEAR ANTINEUTROPHIL CYTOPLASMIC ANTIBODY IN PATIENTS WITH INDETERMINATE COLITIS

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Background: Indeterminate colitis (IC), a term originated by pathologists to characterize confounding histopathlogic appearance of resected mucosa, has become catch phrase for cases in which diagnostic criteria at all levels elude classification as Crohn's disease (CD) or ulcerative colitis (UC).OBJECTIVES: evaluate the prevalence of pANCA expression in the sera and its isotypes. Patients and methods: PATIENTS GROUP consisted of 60 patients (40 males and 20 females) with indeterminate colitis and their age range was (19-84 years). CONTROL GROUP consisted of 30 (15 males and 15 females) healthy volunteers and their age range was (20- 66 years). Antineutrophil cytoplasmic ( pANCA and cANCA) testing was performed by an IIF technique on ethanol fixed human EOH granulocytes as substrate (EUROIMMUNE- Germany). Sigmoidoscope and colonoscope examination were done for the patients group and biopsies were taken from the patients for histopathological examination.Results:Serological results of ANCA showed a significant increased frequency of pANCA (63.3%) in indeterminate colitis patients as compared to controls (p=0.000). The highest percentage of this pANCA titer was 1:10 (p=0.000) then 1:100 (p=0.008) and most of them was IgG (53.3%) (p=0.000). Sensitivity of pANCA was 60%, specificity of pANCA was 40%, positive predictive value of pANCA was 61.1% and negative predictive value of pANCA was 66.6%. cANCA did not demonstrated in both groups. Conclusions : pANCA was more prevalent in indeterminate colitis and could be used as a predictive serological marker for the outcome of disease.


Article
Evaluation of Anti-sperm Antibodies and Some Cytokines Profile in Seminal Plasma of Iraqi Infertile Males

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Abstract

Abstract:This study aimed to investigate the role of seminal plasma anti-sperm antibody (ASA)and cytokines (IL-2, IL-4, IL-10, IL-13, IL-17A and TNF-α) levels in the aetiopathogenesis ofmale infertility in a sample of Iraqi patients.A group of males with primary infertility attending Kamal Al-Samaraie Hospital, Centerof Infertility and in vitro Fertilization (Baghdad) and Baghdad Teaching Hospital (InfertilityClinic) during the period March-August 2010 to October 2010 were enrolled in this study, inaddition, 16 fertile males (control). Based on WHO criteria of 2010 for general seminal fluidanalysis, the patients were distributed into three groups: azoospermic (AZO), Oligozoospermic(OLI), and asthenozoospermic (24 patients for each group). Anti-sperm antibody (ASAs) andcytokines levels were assessed in seminal plasma fluid by Enzyme Linked Immuno SorbantAssay (ELISA).The mean of seminal plasma ASAs in azoospermia and oligospermia patients, as well as,controls showed no significant difference (38.7, 41.2 and 43.8 U/ml, respectively), but the threemeans were significantly lower than the mean (55.4 U/ml) of these antibodies in asthenospermia.when patients and control were evaluated in terms of their positivity for ASAs, the highestfrequency of positive cases was observed in asthenospermia patients (41.7%) followed bycontrols (25.5%), azoospermia (20,8%) and finally oligozoospermia (16.7%), but thesedifferences were not significant when each group of infertility was compared with controls.The mean of IL-2, IL-10, and IL-17A levels in seminal plasma showed no significantdifference between the four investigated groups, while the levels of three cytokines (IL-4, IL-13and TNF-α) showed deviations in infertile patients, but such deviation was subjected to the typeof investigated cytokine and type of infertility. Interleukin-4 and TNF-α were more significant inoligozoospermia patients, while IL-13 was exceptionally increased in asthenozoospermiapatients, and it seemed that the other investigated cytokines had no effect on azoospermia

الخلاصة:IL- و 10 IL- و 4 IL- ھدفت الدراسة الحالیة الى التحري عن دور أضداد النطف ومستوى الحركیات الخلویة ( 2في السائل المنوي في نشوء وامراضیة العقم الذكري في عینة من المرضى العراقیین. ،(TNF-α و IL-17A و IL- و 13شملت الدراسة مجموعة من الذكور المصابین بالعقم الأولي والمراجعین لمستشفى كمال السامرائي لأمراض العقموأطفال الأنابیب ویادة العقم في مستشفى بغداد التعلیمي خلال المدة آذار- آب 2010 وتم انجاز الفحوصات في تشرین الأول2010 ، كما اشتملت الدراسة أیضا 16 من الذكور الخصبین (سیطرة). تم توزیع المرضى الى ثلاث مجامیع استنادا للفحص24 مریض) وقلة ) Azoospermia السریري والتحلیل العام للسائل المنوي وكانت كالآتي: اللانطفیة24 مریض)، وقد توصلت الدراسة الى ) Asthenozoospermia 24 مریض) ووھن النطف ) Oligozoospermia النطفانھ لم یظھر فرقا معنویا في أضداد النطف في البلازما المنویة لمرضى اللانطفیة وقلة النطف وكذلك في أفراد السیطرة ( 3

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