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Evaluation of Anti-sperm Antibodies and Some Cytokines Profile in Seminal Plasma of Iraqi Infertile Males

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Abstract

Abstract:This study aimed to investigate the role of seminal plasma anti-sperm antibody (ASA)and cytokines (IL-2, IL-4, IL-10, IL-13, IL-17A and TNF-α) levels in the aetiopathogenesis ofmale infertility in a sample of Iraqi patients.A group of males with primary infertility attending Kamal Al-Samaraie Hospital, Centerof Infertility and in vitro Fertilization (Baghdad) and Baghdad Teaching Hospital (InfertilityClinic) during the period March-August 2010 to October 2010 were enrolled in this study, inaddition, 16 fertile males (control). Based on WHO criteria of 2010 for general seminal fluidanalysis, the patients were distributed into three groups: azoospermic (AZO), Oligozoospermic(OLI), and asthenozoospermic (24 patients for each group). Anti-sperm antibody (ASAs) andcytokines levels were assessed in seminal plasma fluid by Enzyme Linked Immuno SorbantAssay (ELISA).The mean of seminal plasma ASAs in azoospermia and oligospermia patients, as well as,controls showed no significant difference (38.7, 41.2 and 43.8 U/ml, respectively), but the threemeans were significantly lower than the mean (55.4 U/ml) of these antibodies in asthenospermia.when patients and control were evaluated in terms of their positivity for ASAs, the highestfrequency of positive cases was observed in asthenospermia patients (41.7%) followed bycontrols (25.5%), azoospermia (20,8%) and finally oligozoospermia (16.7%), but thesedifferences were not significant when each group of infertility was compared with controls.The mean of IL-2, IL-10, and IL-17A levels in seminal plasma showed no significantdifference between the four investigated groups, while the levels of three cytokines (IL-4, IL-13and TNF-α) showed deviations in infertile patients, but such deviation was subjected to the typeof investigated cytokine and type of infertility. Interleukin-4 and TNF-α were more significant inoligozoospermia patients, while IL-13 was exceptionally increased in asthenozoospermiapatients, and it seemed that the other investigated cytokines had no effect on azoospermia

الخلاصة:IL- و 10 IL- و 4 IL- ھدفت الدراسة الحالیة الى التحري عن دور أضداد النطف ومستوى الحركیات الخلویة ( 2في السائل المنوي في نشوء وامراضیة العقم الذكري في عینة من المرضى العراقیین. ،(TNF-α و IL-17A و IL- و 13شملت الدراسة مجموعة من الذكور المصابین بالعقم الأولي والمراجعین لمستشفى كمال السامرائي لأمراض العقموأطفال الأنابیب ویادة العقم في مستشفى بغداد التعلیمي خلال المدة آذار- آب 2010 وتم انجاز الفحوصات في تشرین الأول2010 ، كما اشتملت الدراسة أیضا 16 من الذكور الخصبین (سیطرة). تم توزیع المرضى الى ثلاث مجامیع استنادا للفحص24 مریض) وقلة ) Azoospermia السریري والتحلیل العام للسائل المنوي وكانت كالآتي: اللانطفیة24 مریض)، وقد توصلت الدراسة الى ) Asthenozoospermia 24 مریض) ووھن النطف ) Oligozoospermia النطفانھ لم یظھر فرقا معنویا في أضداد النطف في البلازما المنویة لمرضى اللانطفیة وقلة النطف وكذلك في أفراد السیطرة ( 3

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