research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Results of Bone Marrow Examination Over 9 Years Period in Iraqi Patients from Babil Province

Author: Najlaa Bader Alawadi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 1 Pages: 66-72
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

The aim of this study is to assess the results of bone marrow aspiration with or without trephine biopsy in Babil province.In this observational study, 5644 Iraqi patients were included, male: female ratio was 1.3:1 and age range was 1-78 years. The patients attended hospital for bone marrow aspiration with or without biopsy over a period of 9 years from 1st March 2006 till 1st March 2015. Pallor and anemia (55.3 %) were the most common indication. The morphological examination of blood film and bone marrow were performed.The final diagnosis was reached in 93.21% (5261/5644) of patients by morphological examination of bone marrow samples only. However, other 383 (6.78%) of patients needed further advanced tests. The result of BME was normal in 28.72% (1621/5644) of patients which was the most common result.Non-Hodgkin's lymphoma was the cause of bone lytic lesions in a significant number of cases and it should be kept in mind.This study concluded that bone marrow examination is a worthy test and can reach the diagnosis in majority of cases with morphological examination only, and this ratio can be increased by introduction of other supplementary tests like CD markers and immunohistochemistry. Normal results also helped diagnosis by their exclusive value. Doctors must be encouraged to request BME whenever they found it indicated.


Article
Prognostic Significance of Immunohistochemical Overexpression of P53 And Bcl-2 Proteins in Patients with Non-Hodgkin’sLymphoma

Authors: Farah Amer Albejow --- Hadeel Abdul-Elah Kerbal --- Najlaa Bader Alawadi --- Ahmed Raji Kharulla
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 3 Pages: 721-729
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Non-Hodgkin's lymphomas are the hematologic malignancy with the most prevalence worldwide, they are generally classified as B-cell or T-cell lymphoma .Theincidence rate of NHL for the total population is 5.16 % according to Iraqi cancer registry (ICR) in 2010.This study was designed to asses’bcl-2 and p53 overexpression in Iraqi patients with NHL and correlation with different prognostic indices (age, sex, stage, grade, and International prognostic index).Samples included in this study represented as 50 formalin-fixed paraffin embedded lymph node blocks of patients with NHL,during the period from September 2013 till November 2014,and these blocks collected from the histopathology laboratories of Al-Hilla Teaching Hospital as well as many private histopathology laboratories in Hilla city, These blocks stained Immunohistochemically for bcl-2 and p53 protein expression by using L-SAB+ staining methods.Results revealed Significant correlation between bcl-2, p53overexpression and different grades of NHL (p-value < 0.05), while there are no significant relationship between bcl-2, p53 and age, sex, stage, and IPI score (p-value > 0.05).In conclusion there are up regulation of P53 protein associated with down regulation of bcl2 protein in patients with high, intermediate to low grades of NHL while no significant association with IPI score& factors.

Keywords

Non-Hodgkin lymphoma --- P53 --- Bcl-2

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2016 (1)

2015 (1)