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Article
Anticancer Studies of Extracts and Fractions of Hertia Intermedia

Authors: Hakeemullah --- Muhammad Anwar --- Jahangir Khan --- Inayatullah --- et al.
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2020 Volume: 23 Issue: 1 Pages: 43-46
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

This study was conducted to prepare the extract from medicinal plant Hertia intermedia and its evaluation for presence of anticancer activity. The medicinal plant was collected and shade dried then crushed to convert it into powdered form. The powdered form of the plant was soaked for 15 days in an organic solvent methanol (CH3OH). The extract obtained passed through the filtration process followed by vaporization of the residual solvent using rotary evaporator. The methanol extract of Hertia Intermedia was used to prepare differentfractions of solvent using aqueous dichloromethane, benzene,butanol,chloroform, ethyl acetate and n-hexane. Methanol extract, aqueous extract, butanol extract and extract of Hertia intermedia did not show any activity against cancerous cell lines. Hertia intermedia did not show any noticeable activity and remains inactive ROS against HeLa cell line, 3T3 cell line, MCF-7 cell line (cancerous cell). Hertia intermedia did not contain any bioactivity against cancerous or reactive oxygen species which is the initiator or producing cancer.


Article
Detection of Heavy metals in Fruits and Vegetables available in the Market of Quetta city

Authors: Khair Un Nisa --- Samiullah --- Naqeebullah Khan --- Attiq-ur-Rehman
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2020 Volume: 23 Issue: 1 Pages: 47-56
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

This study is conducted for the determination of heavy metals concentration like Fe, Ni, Mn, Co, Cd, Cu and Pb in five edible vegetables (Cauliflower, Cabbage, Cucumber, Lady finger and Tomato), five edible Fruits (Water melon, peach, Banana, Mango (Sindhri & Langra and apple) and peel of all these Fruits and endocarp of apple. Samples were purchased from the Local Market of Quetta city (Capital of Balochistan). Atomic Absorption Spectrophotometer((FAAS, Thermo -Electron Corporation, S4 AA System, Ser. No, GE711544,China) doublebeam and deuterium background hollow cathode lamps of Fe, Pb, Cd,Co, Cu, Ni and Mn were used at specific wavelengths for thedetermination of heavy metals concentration. Samples were run threetimes and at least three or four standards are used for each metalanalysis. Concentration of Fe, Mn, and copper were very much below the permissible limits defined by WHO/FAO. Concentration of Ni was found at toxic level in cucumber. Concentration of Cd was above the safe value in all samples except banana fruit given by WHO/FAO. Concentration of Co was found above the limit defined by ASTDR 1994 in all the samples. Concentration of Pb with respect to the (China food hygiene standards 1994) 0.2mg/kg and WHO/FAO 0.3mg/kg is above the limit in all samples but it found very high in Tomato, Cabbage, Cucumber, Peach and Watermelon. The overall result of this study reveals that the samples of vegetable and fruits are highly contaminated with heavy metals Co, Pb, Ni and Cd due to the usage of drainage water for watering them and their consumption can cause hazardous effect on human health.


Article
Physicochemical and Spectroscopic Elemental Analysis of Ground Water in Thickly Populated and Industrial Area of Quetta Valley Pakistan

Authors: Abdul Baqi Achakzai --- Irshad Ali --- Naqeebullah Khan --- Samiullah Khan --- et al.
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2019 Volume: 22 Issue: 3 Pages: 18-25
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Quetta valley the capital of Balochistan Province, has faced twice the rush of immigrants i.e; Afghan refugees after Saur Revolution and people from interior Balochistan due to drought in Balochishan from the last two decades. Additionally a number of industries at various areas has been established. This abrupt increase in the population and discharge from the industries have affected the drinking water quality in the valley. To assess these affects, nine ground water samples taken from densely populated and industrial areas were analyzed for their physicochemical (taste, order, color, temperature, conductivity, turbidity, alkalinity, pH, total hardness and total dissolved salts) and concentrations of cations (Na, K, Fe, Mn, Co, Ni, Cu, Cd and Pb) by Flame Photometer and Atomic Absorption Spectrometer. The results obtained were compared with both Pakistan National Standards (PNS) for drinking water Quality (2010) and World Health Organization (WHO), standards for drinking water. All the results were in the limits of the standards except cobalt (0.095 – 0.12 mg/L) and cadmium (0.0348 – 0.041 mg/L) which were found to be in high concentrations that are attributed to the anthropogenic activates.


Article
Determination of Antioxidants and Antimicrobial Activities of Platytaenia multicaule

Authors: Najeebullah Kakar --- Samiullah --- Naqeebullah Khan --- Attiq-ur-Rehman Kakar --- et al.
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2019 Volume: 22 Issue: 4 Pages: 19-29
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Determination of antioxidants and antibacterial activities of an important medicinal plant like Platytaenia multicaule has been accomplished for the first time in this contest. Regarding antioxidants and antibacterial activities, the plant was analyzed chemically by means of four well known methods as well as by UV/VIS spectroscopic techniques. The crude extract was obtained from the plant by the utilization of methanol (MeOH) and the antioxidants activities of the crude extract tested. Furthermore, using spectrophotometer the antioxidants capacities were examined via 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) Assay, Total Antioxidant Capacity (TAC), Ferric Reducing Antioxidant Power (FRAP) Assay and Reducing Power (RP) Assays. The capacity of DPPH Assay of P. multicaule was 190 mg/g of ascorbic acid concentration. Additionally, for the TAC and FRAP the values of extracts were 10.85 mg and 40 mg of ascorbic acid/g of P. multicaule extract respectively. In addition, the RP shows 3.29 mg/g of ascorbic acid concentration. The P. multicaule have shown the high antioxidant activity. On the other hand, the antibacterial activity of this plant was investigated by the agar well diffusion method. In this, the plant extracts were examined against two bacteria namely Escherichia coli and Staphylococcus aureus which exhibited 14 mm and 16 mm zones of inhibition respectively. Hence, this test proved that the P. multicaule contains high antibacterial agents.

Keywords

Antioxidant activity --- DPPH --- TAC --- FRAP --- RP --- Antibacterial activity --- Agar.

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