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Article
Evaluation of Cancer Antigens (CA125&CA153-) in some Iraqi women with polycystic ovarian syndrome

Authors: Zainab Faeiq Rzaij --- Nawal Khairy Hussain AL-Ani
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2013 Volume: 3 Issue: 6 Pages: 11-14
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Polycystic ovary syndrome (PCOS) is the most common cause of hyperandrogenism anovulatory infertility; it affects 510- % of females in the reproductive age. PCOS is a risk disease; it has an association with gynecological malignancy.Objectivs:To determine whether Cancer Antigen 125 (CA125) and Cancer Antigen 153-(CA153-) levels are increased in PCOS and possibility of CA125 and CA153- to be used as a diagnostic marker of PCOSMethods:Seventy females with PCOS diagnosed depending on three criteria : Menstrual history of oligomenorrhea , ultrasound examinations revealed polycystic ovaries and biochemical hyperandrogenism. Twenty normal fertile females serve as control group. Blood samples were obtained from all individuals from 2nd-4th day of menstrual cycle to measure levels of FSH, LH and testosterone .Second blood samples were collected from the same patients during late follicular phase to measure CA153- and CA125( by ELISA) .Results:Females with PCOS and controls differed significantly(p<0.05)intotalserumtestosterone(p).Females with PCOS and controls have highly significantdifference(p<0.001) inLH meanlevel(7.881.83+ vs 3.900.73+ ) respectivelyand, highly significantdifference(p<0.001) inLH/FSHratioand BMI parameters. No significantdifferences(p>0.05)werefoundinFSH,CA125andCA153- between PCOS patients and the controls.There were positive correlation between testosterone and CA125.Negative correlation between testosterone and CA153- serum values.Conclusion:There were no changes in the serum levels of CA125andCA153- in PCOS patient at the age of reproduction and those cancer antigens could not be used as diagnostic markers for polycystic ovarian syndrome.

Keywords

PCOS --- CA125 --- CA153- --- Testosterone --- LH --- and FSH


Article
Protective Effects of flaxseed &zincagainst lead induced reproductive toxicity in male mice

Authors: Nawal Khairy Hussain --- Basima Muhan1med Al-.Juboori --- Maison Abd Jasim
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2014 Volume: 4 Issue: 1 Pages: 18-24
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

The toxic effect of drugs and environmental chemicals on the human reproductive system has become a major health concern. Lead is recognized as the most dangerous of the toxic metals and a major threat to the biological systems of both human and animals. In this study we detect the effect of two types of antioxidants: flaxseed and zinc, on the toxicity of low dose of lead acetate on reproductive organs of male mice, this study was conduct.Two groups of mature male mice,exposed to low dose of lead, were administered either zinc sulphate (0. 5mg/kg body weight/day) or flaxseed oil (2.5% of total daily food intake), for 6 weeks. The results showed that lead caused a significant reduction in the total body weight, testicular weights & adverse effects on sperm parameters , while the concomitant administration of antioxidants caused elevation in these weights with significant improvement in sperm quality as compared to the only lead treated group. It is concluded that lead, like all other heavy metals, could induce oxidative stress and the concomitant administration of antioxidants (zinc or flaxseed) can ameliorate the toxic effect of leadon reproduction .

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