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The Association of Methylenetetrahydrofolate Reductase (MTHFR)/C677T Polymorphisms with The Development of Peripheral Neuropathy in Type 2 Diabetes Mellitus

Authors: Nawrass Jassim Al-Salihi --- Ihsan Mohammed Ajeena --- Thekra AB Al-Kashwan --- Zuhair Al-Lebban
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 2 Pages: 452 -458
Publisher: Babylon University جامعة بابل

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Abstract

One of important microvascular complication of patients with T2DM is neuropathy, commonly diabetic peripheral neuropathy (DPN). MTHFE/C677T polymorphisms affect MTHFR enzyme activity with subsequent elevation in the toxic homocysteine concentrations that result in vasculopathy and nerve ischemia. This case control study was planned to estimate the association between the MTHFR/C677T polymorphism and the occurrence of peripheral neuropathy in type 2 diabetic (T2DM) patients in a group of Iraqi peopleEighty three Iraqi subjects were included in this study, 36 had diabetic peripheral neuropathy, 25 without peripheral neuropathy and 22 were healthy control.Genomic DNA was isolated from fresh whole blood and genotyped using the polymerase chain reaction–based restriction fragment length polymorphism assay for the MTHFR gene C677T mutation.The distribution of MTHFR/ C677T mutated genotypes between DPN and healthy groups was statistically differed with increased risk of occurrence of DPN (OR= 3.1, 95% CI: 1.02-9.4, p=0.05), while this risk was highly increased by seven folds when comparing DPN group with those without DPN& 2 (OR= 6.7, CI=2.1-20.8, p=0.0008).MTHFR/C677T polymorphism is highly associated with development of peripheral neuropathy in T2DM Iraqi population


Article
The Duration of Type 2 Diabetes Mellitus as a Risk Factor For The Occurrence of Peripheral Neuropathy

Authors: Nawrass Jassim Al-Salihi --- Ihsan Mohammed Ajeena --- Thekra Abd Jebur Al-Kashwan
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 3 Pages: 570 -574
Publisher: Babylon University جامعة بابل

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Abstract

This research was performed to evaluate type 2 diabetes mellitus duration as a risk factor for development of peripheral neuropathy (DPN).Initially 157 patients with T2DM who fit the general inclusion criteria were collected, but only 61 of them enrolled in this study due to the application of restricted inclusion criteria and according to the results of the nerve conduction study (NCS) those 61 patients divided into two groups, group 1: 36 patients, had diabetic peripheral neuropathy (DPN), and group 2:25 patients without DPN. For all these patients a lot of investigations were performed to exclude any other cause of neuropathy( lipid profile, renal, thyroid functions, fasting blood sugar and glycated hemoglobin).Significant statistical differences in the duration of T2DM between study groups was observed, p value was 0.04.The more duration of T2DM the high risk for diabetic peripheral neuropathy.

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