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Article
Anti-inflammatory Role of IL-4 in Patients with Rheumatic Mitral Valve Stenosis

Authors: Zaman I. L. Al-Kaabi --- Nidhal Abdul-Muhaimen
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 3 Pages: 309-311
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: IL-4 is an antibodies inflammatory cytokine which has an important role in protecting against the inflammatory reactions in most of diseases. Here, we try to highlights the role of this cytokine in chronic Rheumatic heart disease and its correlation with the extent of histopathological abnormalities.Patients and Methods: Rheumatic mitral valve surgical fragments were taken from a total of 48 Iraqi patients with chronic rheumatic heart disease under mitral valve replacement surgery in Ibn Al-Bitar Hospital for Cardiac Surgery-Iraq-Baghdad. Paraffin embedded mitral valve tissue sections were prepared. IL-4-expressing cells were detected by using immunohistochemical staining technique and histopathological picture was studied by using hematoxylin and eosin staining.
Results: There were lower numbers of IL-4 positive cells in all patients under study in general, but very lower IL-4 positive cells percentage was recorded in high risk group patients. There was no significant difference in the distribution of IL-4 mean positive cell’s count among all patients (p > 0.05). There was a correlation of IL-4 with the extent of histopathological abnormalities, and odds ratio results displayed that the histopathological abnormalities which recorded in the case group 4 times than that occurred in the control group.Conclusion: IL-4 plays an important role in regulating the inflammatory responses against the heart in chronic rheumatic heart disease


Article
Serum Cytokine Levels in Patients with Chronic Atopic Dermatitis: a Useful Clinical Marker for Disease Activity

Authors: Nidhal Abdul-Muhaimen نظال عبد المهيمن --- Ahmad Hachem Muhana احمد حاجم مهنا
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2013 Volume: 5 Issue: 2 Pages: 36-42
Publisher: Diyala University جامعة ديالى

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Abstract

Objective: To measure the serum level of IL4, IL10 and IFN-gamma of Atopic patients before and after treatment with tacrolimus ointment or topical steroid by using enzyme linked immunosorbant assay (ELISA) to evaluate the disease activity.Methods: IL4, IL10 and IFN-gamma concentrations in the serum were measured by enzyme-linked immunosorbent assay in fifty atopic dermatitis patients were giving two types of treatment and 43/50 were re-analyzed after one month of treatment with tacrolimus or topical and systemic steroids. The severity of atopic dermatitis was graded on the criteria of Hanifin and Rajika. The disease activity was assessed by each patient on a visual analogue scale (VAS). Results: Higher serum IFN-γ, IL-10 and IL-4 concentrations were found in AD patients sera at the time of diagnosis and correlated with disease activity before and after treatment. Serum IFN-γ, IL-10 and IL-4 concentrations also correlated with VAS scores for itching, skin condition; overall skin symptoms and total VAS score. Serum IFN-γ concentration could be a good indicator to define the degree of the general activity in chronic AD patients, also IFN-γ can play a role in the immuno-pathogenesis of AD, and furthermore may be used in the diagnosis and follow up of the disease in addition to other parameters.Conclusion: The sera of patients group revealed a statistically significant increase in the concentration of IFN-gamma, IL-4 and IL-10 before treatment when compared with that of the same patients after treatment with topical tacrolimus-steroid and also there were no statistically significant differences between two treatments.


Article
TNF-a and Autoimmunity in chronic rgeumatic heart disease

Authors: Zaman I.Al kaabi زمان الكعبي --- Nidhal Abdul Muhaimen نضال عبد المهيمن
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2011 Volume: 53 Issue: 1 Pages: 77-81
Publisher: Baghdad University جامعة بغداد

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Abstract


Article
Estimation the concentration of IL- 23, and IL-17A in the sera of patients with psoriasis in Baghdad city
تقدير تركيز الانترليوكين-23 والانترليوكين-17أ في مصول مرضى الصدفية في مدينة بغداد

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Abstract

Abstract: Psoriasis is a common, chronic, disfiguring, inflammatory, hyperproliferation, and abnormal differentiation of keratinocyte, in which both genetic and environmental influences have a critical role. The study was designed to detection the levels of IL-23 and IL-17A among psoriatic patients compared with healthy group, also studied the correlation between them and some parameter such as:-age of onset and severity of psoriatic patients. Fifty psoriatic patients were selected randomly from both sexes with ages from (10-70) years. Patients were diagnosed clinically by dermatologist. Sera samples of both groups were collected from all individuals for the estimation levels of IL-23 and IL-17A by ELISA technique. All mean values sera levels (IL-23 96.74 pg/mL and 6.56 pg/mL for IL-17A ) of patients were significantly higher than those of controls (18.74 and 3.01 pg/mL for IL-23and IL-17A respectively). There was a high significant in levels of patients sera of IL-23 and IL-17A, in compared with healthy control group according to these normal values. Furthermore, there was a significant correlation between the levels of IL-23, and age of disease onset among psoriatic patients. In contrast there was no significant association between the severity & interleukins (Il-23 and Il-17A). Emerging data in humans reveals a critical contribution of IL-23 and IL-17A in the pathogenesis of psoriasis. The IL-23 and IL-17A pathways were atherapeutic targets for biologic agents and systemic therapies in psoriasis treatment

الخلاصة:الصدفية مرض جلدي شائع مزمن والتهابي يزداد فيه التكاثر والتمايز غير الطبيعي للخلايا المتقرنه التي يؤثر فيها العوامل الوراثية والبيئية على حد سواء بدور حاسم. صممت هذه الدراسه لكشف مستوى الانترلوكين23 والنترلوكين17أ بين مرضى الصدفية ومقارنتهم بمجموعة الاصحاء وكذالك دراسة الارتباط بينهم وبعض المتغيرات مثل عمر بداية ظهور المرض وشدة المرض لدى مرضى الصدفية. ضمت الدراسة خمسين مريضا بداء الصدفية تم اختيارهم بشكل عشوائي لكلا الجنسين وكانت اعمارهم تتراوح من (10-70) سنة. شخص المرضى سريريا بواسطة اخصائي الجلدية. وقد تم جمع العينات المصلية لكلتا المجموعتين ولكل الافراد وذلك لتقدير مستويات الانترلوكين 23 والانترلوكين 17أ بتقنية اليزا. اظهرت نتائج الدراسة اختلافات معنوية عالية في متوسطات المستويات المصلية لكل من انترلوكين 23 (74و96 بيكوغرام/مل) وانترلوكين 17أ (56و6 بيكوغرام/مل) لدى جميع مرضى الصدفية مقارنة بالاصحاء (74و18 و 01 و3 بيكوغرام/مل) للانترلوكين 23و17أ على التوالي. كمااظهرت الدراسة وجود فروقات معنوية عالية في مستويات مصول المرضى للانترلوكينات 23 و17أ عند مقارنتها بمجموعة الاصحاء بحسب مستوياتها الطبيعية. ومن ناحية اخرى هناك ترابط معنوي بين مستويات الانترلوكين 23 وعمر بداية ظهور المرض لدى مرضى الصدفية . وهناك نتيجة مغايره بعدم وجود ارتباط معنوي بين شدة المرض ومستويات الانترلوكينات (23 و17أ). الحقائق المنبثقه من الانسان كشفت مساهمة حاسمة للانترلوكينات 23 و17أ في امراضية داء الصدفية وان الانترلوكينات( 23 و17أ) لها مسارات في الاهداف العلاجية فيما يتعلق بالعوامل الحيوية والعلاجات الجهازية في معالجة داء الصدفية.

Keywords

Psoriasis --- IL-23 --- IL17A

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