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Article
Salivary and Serum Oxidant/Antioxidant Level in Behçet’s Disease Patients

Author: Noor H. Mohammad
Journal: Journal of Oral and Dental Research مجلة طب الفم والاسنان ISSN: 23106417 Year: 2017 Volume: 4 Issue: 2 Pages: 149-157
Publisher: Iraqi Association for Oral Research الجمعية العراقية لبحوث طب الفم

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Abstract

Background Behçet’s disease (BD) is a multi-systemic inflammatory disorder characterized by recurrent oral and genital ulceration. Free oxygen radicals may have a role in the pathogenesis of BD and can relate to the existence of the disease.Objectives This study had been designed to assess salivary and serum lipid per-oxidation as malondialdehyde (MDA) and status of antioxidant as total glutathione (GSH) in patients with BD in comparison with healthy subjects to detect the possible involvement of oxidative stress in BD. Materials and methods This is a case–control study, salivary and serum samples were taken from ffty BD patients with an age range 20 to 56 years with mean age 35.3 ± 7.6 years and ffty healthy control subjects with age range 16 to 58 years and mean age 34.8± 9.1 years. All were analyzed for MDA and GSH spectrophotometrically. Data was analyzed using descriptive statistics, t-test, P (ANOVA) test, Chi-square (2X) test, Pearson correlation and Receiver Operating Characteristic statistical analyses. Results The study showed that salivary and serum MDA level was higher in BD patients than in healthy subjects (P<0.05 and P<0.001 respectively). The levels of saliva and serum total GSH were signifcantly lower in BD patients than in healthy subjects. (P <0.001). Conclusion The results of this study revealed that BD patients were subjected to oxidative stress damage and saliva could be used as pain-free alternatively to serum in determining oxidative stress in Behçet’s disease.

Keywords

Behçet’s disease --- MDA --- GSH --- saliva --- serum


Article
Salivary and Serum Levels of Both Uric Acid and C-Reactive Protein (CRP) Biomarkers in Patients with Behçet's Disease

Author: Noor H. Mohammad
Journal: Tikrit Journal for Dental Sciences مجلة تكريت لعلوم طب الاسنان ISSN: 20731213 Year: 2017 Volume: 5 Issue: 1 Pages: 143-149
Publisher: Tikrit University جامعة تكريت

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Abstract

Behçet's disease (BD) is a systemic vasculitis identified by recurrent oral and genitalulcerations, skin inflammations and uveitis, with unknown etiology. This study had beendesigned to assess the level of salivary and serum uric acid (UA) and C - reactive protein(CRP) markers in BD patients as activity markers and to explore their relations in diseaseexistence. Fifty BD patients :( 32 males and 18 females) with mean age (35.3 ± 7.6) yearsand fifty healthy subjects (30 males and 20 females) with mean age (34.8± 9.1) years wereinvolved in this study that extend during the period of (2014-2016). All of patients andhealthy subjects were analyzed for UA by (colorimetric spectrophotometric assay that basedon oxidation of UA by uricase enzyme to allantoin) and CRP by (qualitative analysis:antigen-antibody interaction Latex agglutination test) in both saliva and serum. Data wasanalyzed using descriptive statistics, t-test, P (ANOVA) test, Chi-square (2) test, andPearson’s linear correlation coefficient statistical analyses. Results of this study show thatsalivary uric acid was significantly elevated in BD patients than in healthy subjects.(P<0.001). Although serum UA was higher in patients than the healthy subjects butstatistically not significant. (P=0.57). On the other hand, out of fifty patients there werethirteen patients (26%) significantly expressed CRP positive in their serum and saliva. Theresults of this study revealed that UA can act as prooxidant (pro inflammatory) marker andCRP as inflammatory marker that could be related to impaired endothelial

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