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13.EVALUATION OF ANTEMORTEM AND POSTMORTEM LEVELS OF ORGANOCHLORINE PESTICIDES IN A SAMPLE OF IRAQI PEOPLE

Authors: Harb S. Hmood حرب سلمان حمود --- Noor M. Ali نور مصطفى علي --- Muataz A. Al-Qazzaz معتز عبد المجيد القزاز
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2017 Volume: 15 Issue: 4 Pages: 420-430
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Organochlorine pesticides have long been widely used in agriculture and in public health as highly effective pest control agents. They are lipophilic and have prolonged half-lives of years to decades; as a consequence, they accumulate in human adipose tissues and can cause chronic toxicity after long-term exposure.Objective: To detect and measure the concentrations of organochlorine pesticides (trans-nonachlor and oxychlordane) in postmortem organs and fatty tissue as well as their concentrations in antemortem serum and fatty tissue samples and study their correlation with lipids in order to reveal the need for human monitoring.Methods: The study was conducted on 40 antemortem samples of blood and fatty tissues and 41 postmortem samples of blood and different organ tissues to determine their lipid concentrations and detect metabolites of organochlorine pesticides and asses their correlations using spectrophotometer and HPLC techniques. Results: The study observed that there was normal serum concentration of triglyceride (TG) and elevated cholesterol level, which were verse correlated with elevated serum concentrations of trans-nonachlore and oxychlordane pesticides. Serum concentrations of TG were (153.75 mg/dl) within “normal” range while mean serum of total cholesterol was (209.89 mg/dl) elevated above normal range. Percentage of concentration of serum to lipid trans-nonachlordane was (40.28 mg/dl) higher than that of oxychlordane was (28.42 mg/dl) in living subjects. The study observed that elevated concentrations of trans-nonachlor more than oxychlordane in postmortem tissue organs.Conclusion: The study revealed that traces of organochlorines (trans-nonchlore and oxychlordane) were detected in human serum, fatty tissue and postmortem organs and positively correlated with some lipid profiles indicating the presence of human contamination. Both trans-nonchlore and oxychlordane were higher in lipid tissue than in serum and other tissues among postmortem cases.Keywords: Organochlorine, trans-nonachlore, oxychlordane, postmortem, lipid profileCitation: Hmood HS, Ali NM, Al-Qazzaz MA. Evaluation of antemortem and postmortem levels of organochlorine pesticides in a sample of Iraqi people. Iraqi JMS. 2017; Vol. 15(4). 420-430. doi: 10.22578/IJMS.15.4.13


Article
8.4-Hydroxy-2-nonenal, Induced Nitric Oxide Synthase Status in Hypertension with Kidney Disease Patients

Authors: Ali D. Hammed علي ظافر حميد --- Alaa H. Jawad علاء حسين جواد --- Noor M. Ali نور مصطفى علي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2019 Volume: 17 Issue: 2 Pages: 146-152
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:The oxidative stress is one of the main reasons for cardiovascular diseases and also one of results of these diseases, its development (like kidney disease).Objective:To identify the effect of oxidative stress nitric oxide and reactive oxygen species on cardiovascular diseases.Methods:The study involved 56 subjects comparable in age and sex divided into two groups; 28 hypertensives subjects with kidney disease and 28 apparently healthy subjects as control group. The following analysis was done: 4-Hydroxy-2-nonenal (4HNE), Induced nitric oxide synthase (iNOS) and albumin.Results:There was a significant increase in (4HNE) between patients' group and control group. iNOS was significantly higher in patients as compared to controls while there were no significant differences found in albumin between patient and control group. There is a positive relationship between oxidation results from hypertension and their developments. There is a positive correlation between BMI and disease.Conclusion:Based on this study is important on ideal weight, because obesity considered main factors for heart disease and hardening of the arteries. In addition, the effect of oxidative stress, which leads to high blood pressure and thus chronic kidney disease.Keywords;Chronic kidney disease, hypertension, 4-Hydroxy-2-nonenal (4HNE), Induced nitric oxide synthase (iNOS), albumin, creatinine, reactive oxygen speciesCitation:Hammed AD, Jawad AH, Ali NM. 4-Hydroxy-2-nonenal, induced nitric oxide synthase status in hypertension with kidney disease patients. Iraqi JMS. 2019; 17(2): 146-152. doi: 10.22578/IJMS.17.2.8


Article
THE EFFECTIVENESS OF SYSTEMIC CO-ENZYME Q10 IN VITILIGO

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Abstract

Background:Vitiligo is the most frequent depigmentation disorder of the skin. None of the therapeutic alternatives is satisfactory.Objective:To evaluate the effectiveness of systemic Co-enzyme Q10 in patients with vitiligo.Methods:Twelve patients received Co-enzyme Q10 75 mg twice daily compared with 12 patients received placebo capsule twice daily orally for 8 weeks in the Department of Dermatology, Al-Kadhimiya Teaching Hospital (November 2011 to march 2012). History of patients was taken and measurement for serum glutathione (S. GSH) (by Elleman methods), malonialdehyde (S. MDA) (by Stocks and Dormandy methods) and VASI score at baseline, 4 and 8 weeks interval.Results:No significant difference in S. GSH was found between Co-enzyme and placebo group after 4 and 8 weeks. High significant decrease in S. MDA occurred after 4 and 8 weeks with significant decrease in VASI were found after 8 weeks.Conclusion:Co-enzyme Q10 may have a role in treatment of vitiligo.Keywords:Co-enzyme Q 10, Vitiligo, Antioxidant.

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