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Introduction: polycystic ovary syndrome (PCOS) is one from record common endocrine disorders, which is complicated in the multi system disease and its etiology is silent not clearly understood. The environment factors and the genetic factors production a crucial role in the pathogenesis of PCOS. The obesity is android in type with greater waist to hip ratio and obese in posterior abdominal wall and mesentery. Due to that (50%) of women with PCOS are fat, additional the possibility of insulin resistance is the development of type 2 diabetes. Aims of the study to estimate the role of TNF-α and insulin resistance in pathogenesis of PCOs and identify the relationship of obesity with IR and TNF-α in PCOs. IR and TNF-α concentration was assessed by competitive ELISA method. Significant of differences were detected between PCOS patients and controls. Each the PCOS had raised up BMI, WHR, fasting insulin, homeostatic model assessment (HOMA) score, and serum TNF-α when matched with controls (p<0.05). The conducted examination indicated the contribution of TNF-α in path mechanism of PCOS being the basis of increase body weight which lead to development of insulin resistance.

Polycystic ovary syndrome --- Tumor necrosis factor alpha --- insulin resistance --- body mass index --- waist to hip ratio