research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Histopathological and Immunohistochemical Study of Giant Cell Granuloma of the Jaw and Giant Cell Tumor of Long Bones (Comparative Study)

Authors: Luay Edward. M --- Bashar H. Abdullah --- Omar A. Kader
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 1 Pages: 33-39
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Central giant cell granuloma (CGCG) and peripheral giant cell granuloma (PGCG) are tumor like lesions that affect jaw bones, while giant cell tumor (osteoclastoma) is a tumor that affects the long bones (e.g. tubular bones). Its affection of the jaw bones is a matter of debate. Both are very similar in their histopathological features while they vary in their clinical behavior. GCT shows a more aggressive behavior than GCG.OBJECTIVE:To evaluate the expression of (Proliferating cell nuclear antigen) and (P53) in peripheral and central giant cell lesion of the jaw and giant cell tumor of long bones with correlation to histopathological parameters.METHODS:A total of 17 (GCT), 15 (CGCG) and 16 (PGCG) cases where enrolled in this study. Immunohistochemical staining with PCNA and P53 monoclonal antibody was performed.RESULTS:A non-significant difference in proliferative activities was recorded among different histological giant cell lesion subtypes. Giant cell granuloma expressed the same proliferative potential to that of giant cell tumor, moreover PCNA expression was not statistically correlated to different histopathological paramters of lesion subtype.On the other hand. The anti-apoptotic potential of giant cell granuloma which expressed by anti P53 monoclonal antibody was the same of that of giant cell tumor.CONCLUSION:Results of this study proved that the biological behavior namely P53 and PCNA activities was comparable between giant cell lesions and giant cell tumor. This suggest that these two conditions may act as one disease entity with a spectrum of clinical behavior, possibly due to certain differences in anatomical location which by itself affect its biological behavior. This hypothesis needs further verification concerning the clonality of the lesion to be accepted or refused


Article
The effect of orthodontic relapse on the proliferation of fibroblast and epithelial rests of Malassez in periodontal ligament of rat molars (A histopathological study)

Authors: Munad J. Al-Duliamy --- Ghada M. Mustafa --- Omar A. Kader
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 4 Pages: 114-119
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Relapse of previously moved teeth, is major clinical problem in orthodontics with respect to the goals ofsuccessful treatment. This study investigated the effect of orthodontic relapse on the proliferation of fibroblast andepithelial rests of Malassez cells in periodontal ligament of rat molars.Materials and Methods: Sixteen ten-week- old male Wister rats were randomly divided into four groups composed offour animals each: Group I received no orthodontic force (control). In both Group II and Group III, uniformstandardized expansive springs were used for moving the maxillary first molars buccally for periods of one and threeweeks respectively. The spring initially generated an average expansive force of 20 g on each side. In Group IV thesprings were left for three weeks, until the maxillary first molars moved buccally, after that the springs were removedand the animals were scarified after three weeks of relapse tooth movement. After the humanly scarification ofanimals, each maxilla in all groups was dissected into two halves each half including the three maxillary molars andprocessed for histological examination. The number of both fibroblast and ERM cells in each cluster was counted inthe PDL of the pressure side of the mesio-buccal roots of the maxillary right and left first molars in all groups and thesurface areas of the ERM clusters were also measured in all groups.Results: The number of fibroblast was significantly increased at the end of active movement (Group III) andsignificantly very highly increased during the relapse period (Group IV). Regarding the ERM cells there werestatistically significant increase in both the number of cells in each ERM cluster and the surface areas of the ERMclusters in Group III and highly significant increase in Group IV, while Group II showed no significant differencesregarding all measurements.Conclusions: It was concluded that fibroblast and ERM cells may play an important role during orthodontic relapse

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2013 (1)

2011 (1)