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Article
Immunohistochemical Detection of MDA –DNA Adducts in Oral Mucosa of Smokers and Nonsmokers

Authors: Ali Hassan AL–Timimi --- Raad Ali Jassim
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 2 Pages: 150-157
Publisher: Babylon University جامعة بابل

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Abstract

Malondialdehyde (MDA) is a major lipid peroxidation product that is mutagenic and tumorigenic. MDA-modified DNA adducts have been detected in animal and human tissues and may be a marker of human cancer risk. An immunohistochemical method, using a previously generated monoclonal antibody specific for MDA–DNA adducts, has been developed for the detection and quantification of DNA damage in human oral mucosa cells. The method was used initially on mice liver cells treated with and without MDA, and then applied to the detection of adducts in oral mucosa cells of smokers and non-smokers. Levels of DNA damage were elevated in 25 smokers (mean relative staining intensity 97 ± 41) compared with 25 age-, and sex-matched non-smokers (74 ± 17, P < 0.02). These results demonstrate that MDA–DNA adducts can be measured in single cells of human samples by an immunohistochemical method. This methodology provides a simple way to monitor MDA–DNA damage and should be useful for studies investigating the role of exogenous and endogenous agents in oxidative stress and carcinogenesis.

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Article
clinico-pathological study of leukoplakia in babylon
داء الابيضاض الفموي ( الطلوان) دراسة سريرية مرضية

Authors: Raad Ali Jassim --- Ali Hassan AL- Timimi
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2005 Volume: 10 Issue: 4 Pages: 635-642
Publisher: Babylon University جامعة بابل

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Article
Clinical Evaluation of Bovine Derived Xenograft with a Bioabsorbable Collagen Membrane in the Treatment of Molar Class II Furcation Defects

Authors: Zainab Muhi H. Al-Fatlawi --- Raad Ali Jassim --- Zeyad Nazar M. Al-Talib
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2013 Volume: 10 Issue: 3 Pages: 613-624
Publisher: Babylon University جامعة بابل

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Abstract

The aim of this study is to clinical evaluation bovine derived xenograft with guided tissue regeneration membrane used was osseoguardresorbable collagen membrane in the treatment of human periodontal Class II molar furcation defects. Ten patients(6 males, 4 females) suffering from chronic periodontitis, with Grade II molar furcation defect, were treated using bovine derived xenograft with GTR membrane, completed the study with the following clinical parameters were assessed immediately before the surgical procedure(Baseline) and at 6 months after treatment. These parameters were, Plaque index Score(PlI),gingival index (GI) vertical probing depth (VPD) ,clinical attachment level (CAL),gingival recession(GR) and closed horizontal probing depth (CHPD).This therapy resulted in significant VPD reductions and no significant improvement was seen (CAL),(GR) and significant reduction of(CHPD). For the mean values for the of (VPD)(5.3 ± 1.35),(CAL)( 3.5±1.4),(GR)( 0.3±0.51) and(CHPD)( 4.8±0.99) at baseline ,while these parameters at 6 months after surgical treatment were(2.82 ± 1.56),(2.3± 1.4), (0.28±0.5)and(2.2±1.54) respectively.The findings of this study suggest improvement in clinical results when the use of resorbable collagen membrane with bovine derived xenograft in treatment of class II molar furcation involvement.

الهدف من هدة الدراسة هو لتقييم القياسات السريريةالناتجة عن استخدام الطعم العظمي المشتق من الابقار مع غشاء كولاجين ذائب في علاج مجموعة من الناس لديهم اضراس فيها منطقة تشعب او تفرع جذور مصابة سريريا (درجة ثانية) و هذة القياسات تمثلت بعمق الجيب اللثوي العمودي وفقدان التعلق السريري و انحسار اللثة و عمق الجيب العرضي و مقارنة هدة النتائج مع نفس القياسات ولكن بعد مرور ستة اشهر من العلاج باستخدام التجريف الجراحي.العينة تكونت من 10اشخاص مصابين بالتهاب لثوي مزمن يرافقة اضراس فيها منطقة تشعب او تفرع الجذور مصابة سريريا(درجة ثانية) .التحليل الاحصائي للقراءة الاولى و القراءة الثانية بعد ستة اشهر اوضحت النتائج ان نقصان عمق الجيب اللثوي العمودي وفقدان التعلق السريري و انحسار اللثة و عمق الجيب العرضي مما يدل على تحسن سريري واضح في علاج هذة الاضراس التي فيها منطقة تشعب او تفرع جذور المصابة سريريا باستخدام التجريف الجراحي و الطعم العضمي المشتق من الابقار.

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