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The effect of Tumor Necrosis Factor alpha inhibitor on wound healing of oral mucosa in induced diabetic rats
تأثير مثبطات ألفا نخر الورم على التئام الجروح في الغشاء المخاطي للفم في الفئران التي يسببها السكري

Authors: Farhad F. Fareed --- Rafah Al- Maroof
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2016 Volume: 20 Issue: 1 Pages: 1186-1198
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Impaired wound healing is a major complication of diabetes mellitus. This study was carried out to determine the healing process of oral mucosa in diabetic rats and the role of systemic tumor necrosis factor alpha inhibitor (infliximab). Methods: Thirty eight male rats were divided into two groups, the normoglycemic group (11 rats), and diabetic group (27 rats) that were rendered diabetic by alloxan injection. Two months later, wound was created in the lateral side of the tongue for both groups. The diabetic group was then subdivided into two subgroups, 14 rats received 5mg/kg infliximab subcutaneous injection at the day of wound creation while the other 13 rats received saline injection. After 7 days, biopsies of the tongue were collected and subjected to histological and histochemical procedure. Results: Histological examinations showed delayed healing in the diabetic group with persistence of epithelial discontinuity, large amount of granulation tissue and destruction of the underlying muscle fibers. In the subgroup injected with infliximab, reepitheliazation of the wound was demonstrated with well arranged underlying collagen fibers. Using PAS stain, diabetic group revealed a dramatically high amount of PAS positive precipitants in the lamina properia, especially in the wall of the blood vessels, while with infliximab injection, the PAS+ve precipitants were more prominent than normoglycemic group but less than diabetic group without infliximab. Conclusion: These findings suggest that infliximab accelerated mucosal wound healing in the diabetic rats with the formation of well organized connective tissue.

Keywords

Diabetes --- infliximab --- wound healing


Article
The effect of sialoprotein local injection on dental anchorages for orthodontic tooth retraction in dogs
تأثير الحقن الموضعي ل sialoprin على مراس الأسنان من أجل تراجع تقويم الأسنان في الكلاب

Authors: Fadhil Y. Jasim --- Rafah Al- Maroof --- Omar Fawzi Chawshli
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 3 Pages: 773-780
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Bone sialoprotein is a mineralized tissue-specific protein expressed in differentiated osteoblasts that appear to function in the initial mineralization of bone. The aim of this study was to investigate the effect of local bone sialoprotein on increasing the rate of anchorage during orthodontic tooth movement.Methods: This study used 14 dogs wearing orthodontic appliance for 40 days. They were divided equally into two groups; experimental group that injected with 0.1 µg /10µL sialoprotein around the anchoring tooth in three different time intervals, while the other control group received normal saline injection. Different clinical measurements including loss of anchorage, space closure, rotation, tipping and extrusion were done on the stone casts of each dog before and after tooth retraction. Results: Clinical measurements revealed a highly significant difference between experimental and control group regarding loss of anchorage and space closure. The sialoprotein injected group showed less loss of anchorage than control group and the space closure was higher in experimental group than in the control group.Conclusion: This study showed that the local injection of sialoiprotein reduced movement of the anchoring tooth during orthodontic treatment and provided higher stability for the anchoring tooth.

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