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Article
Evaluation of oral health status in a sample of autistic male children

Authors: Mayyadah H. Rashid ميادة رشيد --- Raja H. Al-Jubouri رجاء الجبوري
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 2 Pages: 62-65
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Autism is a severe neurodevelopmental disorder, presents in early childhood, characterized by severeimpairments in socialization, communication and behavior. Autism is considered a multi-factorial disorder that isinfluenced by genetic, environmental, and immunological factors with oxidative stress as a mechanism linking thesefactors. Assessment of any oral manifestations has to be discovered, evaluated and measured in autistics to be usedas a potential diagnostic.Materials and methods: Oral health status:(DMFT) for permanent teeth, (dmft)for deciduous teeth and gingivalindices were estimated for 58 individuals aged (2-13) years, twenty nine of them were autistics and twenty nine weresex and age matched healthy controls.Results: The results of this study showed that Iraqi autistic children sample was more likely to be caries-free comparedwith healthy sample.Conclusion: Children with autism spectrum disorder (ASD) were more likely to be caries-free, had lower DMFT dmftand GI scores than did their unaffected peer and can be used in autism spectrum disorder prediction to a limitedextent.


Article
Assessment of cadmium levels in Blood, hair, saliva and teeth in a sample of Iraqi workers and detection of dental findings

Authors: Raja H. Al-Jubouri رجاء الجبوري --- Ammar Issa Bashbosh عمار عيسى بشبوش
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: special issue 1 Pages: 60-64
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Cadmium considered one of the heavy metals, by time can be accumulate in plants, animals andhumans. This study aimed to using some biomarkers (blood, hair, saliva and teeth), that can be easily obtained andprocessed for measuring the cadmium concentration in human body and assessment of DMF/t which may resultfrom accumulation of cadmium.Subjects, Materials and methods: This study had been done between April – October of 2010 at Al-kufa CementFactory in Najaf , the numbers of exposed subjects were 55 and control subjects were 44, blood, hair ,saliva andteeth were taken as biomarkers then DMF/t were calculated. After processing of these biomarkers (blood, hair, salivaand teeth) cadmium analyzed by using atomic absorption spectrophotometer device (AAS).Results: The study reported that blood ,hair ,saliva and teeth are good biomarker for measuring the concentration ofcadmium in addition to effect of some factors like smoking habit , residency, age and in accumulation of thatheavy metal in addition to increasing of the numbers of decayed and missing teeth with increasing of cadmium butwithout increasing in numbers of the filling teeth. Also there was significant difference in cadmium concentrationbetween exposed and control peopleConclusions: This study reported that there was significant increased in cadmium concentration among exposedsubject if compared with control subject. Also indicated that factors like smoking habit, residency and age could ledto increasing the cadmium concentration. In addition to increased the numbers of decay and missing teeth whenthe cadmium concentration was increased in these biomarkers

Keywords

Cadimum --- saliva --- blood --- hair teeth


Article
The study of tempromandibular joint disorders and anticyclic citrullinated peptide antibodies in serum and saliva of patients with rheumatoid arthritis

Authors: Raya M. Khidhir ريا خضر --- Raja H. Al-Jubouri رجاء الجبوري
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: special issue 1 Pages: 67-71
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Rheumatoid arthritis is an autoimmune disease that affects mainly the synovial membranes andarticular structures and is characterized by chronic, systemic inflammation involving multiple joints.Being a synovialjoint, the Temporomandibular Joint is subject to the same disorders affecting other synovial joints, including RA.Besideit was considered as a specific serological marker for diagnosing RA disease ,antibodies to cyclic citrullinatedpeptide have proven to be associated with joints destruction, though; it may play a potential role in the predictionof the disease severity.Materials and Methods: Sixty nine individuals (69) were enrolled in this study, forty nine (49) were patients diagnosedwith Rheumatoid Arthritis, and twenty (20) were healthy control subjects. Blood and saliva samples were taken fromeach subject for immunological analysis of Anti-Cyclic Citrullinated Peptides antibodies by ELISA. Each patient withRheumatoid Arthritis disease was examined by means of Research Diagnostic Criteria for Temromandibular Disordersfor the assessment of tempromandibularjoint involvement.Results: Frequency of positive serum Anti-CCP antibodies was higher in rheumatoid arthritis patients compared tohealthy controls (p=0.000).Tempromandibular joint clinical findings were bilaterally involved except joint sounds,sometimes; it was unilateral. Chronic rheumatoid arthritis patients associated with higher prevalence oftempromandibular joint disorders than newly diagnosed RA, except limited mouth opening which were prevalent innewly diagnosed RA patients, (p=0.012) was significant.Positive serum Anti-CCP rheumatoid arthritis patients wereassociated with higher frequency of tempromandibular joint disorderscompared with RA patients with negativeserum Anti-CCP, a non-significant difference was found.Conclusions:Anti-Cyclic Citrullinated Peptide antibodies are considered as a biomarker of inflammation and diseaseactivity. Tempromandibular joint disorders are frequently involved in rheumatoid arthritis patients. Rheumatoid arthritispatients with positive serum Anti-Cyclic Citrullinated Peptides antibodies associated with higher frequency oftempromandibular joint disorders


Article
Evaluation of oral health status in patients receiving antiepileptic medications

Authors: Farqad Najm Abed فرقد نجم عبد --- Raja H. Al –Jubouri رجاء الجبوري
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 2 Pages: 69-73
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Epilepsy is a common neurological disorder of incidence rate 1-2%. Genetic, congenital,developmental, tumors, head trauma and central nervous system infections maybe the cause of epilepsy. This studyaimed to determine the prevalence of stomatitis, xerostomia and taste disorder among patients takingcarbamazepine or sodium valproate and to make salivary analysis for IgA, cystatin c and salivary flow rate.Material and method:This study performed in al- Yarmuk teaching hospital in Baghdad, Samples consist of (70)epileptics half of them treated with carbamazepine and other half treated with sodium valproate, and (18) healthycontrol group of both genders and with different ages to detect the prevalence of oral manifestations, salivary IgAand cystatin C changes.Results: Salivary IgA is significantly higher in epileptics than healthy group. DMFT is significantly lower in epileptics thanin healthy control. GI is hardly affected by epilepsy. Salivary flow rate was significantly lower in epileptics than thehealthy control group. On the other hand, cystatin C was obviously higher in epileptics but failed to reach the levelof statistical significance. Mucositis in epileptics was significantly higher. Candidal infection and Dysguisia failed toreach the level of statistical difference.Conclusion: The most affected oral measurement by epilepsy was salivary IgA then salivary flow rate followed byDMFT. Cystatin C had a marginal contribution to the context of case –control discrimination.Sodium valproate is saferthan carbamazepine when compared by its effects on the oral health. Mucositis, candida infection and dysguisiawere lower in epileptics who were treated with Sodium valproate. Salivary flow rate was higher in Sodium valproate -treated group than in carbamazepine group. GI and DMFT were lower in sodium valproate treated group than thecarbamazepine group

2%. الأورام الوراثیة والخلقیة والتنمویة، الصدمات النفسیة والتھابات الجھاز العصبي المركزي ھي من اھم اسباب الصرع. - الصرع اضطراب عصبي شائع معدل الاصابة 1ھدف دراسة: لتحدید مدى انتشار اضطراب التھاب الفم، وجفاف الفم، والذوق بین المرضى الذین یتناولون كاربامازبین أو الصودیوم فالبرویت وتحلیل امیونو غلوبیولین أ، سیستاتین جومعدل تدفق اللعاب .المواد والطریقة: ھذه الدراسة أجریت في مستشفى الیرموك في بغداد، تتكون العینات من ( 70 ) مریض مصاب بالصرع یتم علاج نصفھم مع كاربامازبین، والنصف الآخر معفالبرویت الصودیوم، وفریق مراقبة صحیة ( 18 ) من كلا الجنسین ومع الإعمار المختلفة للكشف عن انتشار التغییرات الشفویة، امیونو غلوبینالنتائج: امیونو غلوبیولین أ أعلى بكثیر في الصرع من مجموعة المراقبة. مقیاس التسوس أقل بكثیر في الصرع مما في مجموعة المراقبة. مقیاس التھاب اللثة لا یكاد یتأثر بالصرع.وكان معدل تدفق اللعاب أقل بكثیر في الصرع من مجموعة المراقبة الصحیة. في حین ان السیستاتین ج كان أعلى في الصرع ولكنھ فشل في الوصول إلى مستوى الدلالة الإحصائیة.التھاب الغشاء المخاطي في الصرع كان أعلى بكثیر. الإصابة بالفطریات وتغییرات التذوق فشلتا في التوصل إلى مستوى الفرق الإحصائي.الاستنتاج: المقساس الشفوي الأكثر تأثرا بالصرع كان الامیونوغلوبیولین أ ثم معدل تدفق اللعاب تلیھا مقیاس التسوس. وكان سیستاتین ج ذو مساھمة ھامشیة في سیاق التمییزبینالمصابین والاصحاء. فالبرویت الصودیوم أكثر أماناً من كاربامازبین إذا ما قورنت بإثارة على صحة الفم والأسنان. التھاب الغشاء المخاطي والفطریات واضطرابات التذوقكانتأقلفیالصرعالذینیتم علاجھمبفالبرویتالصودیوم. وكانمعدلتدفقاللعابأعلىفیمجموعة فالبرویتالصودیومممافیمجموعةكاربامازبین. مقیاس التھاب اللثھ ومقیاس التسوسكانتأقلفیمجموعةفالبرویتالصودیوم مما ھي علیھ في مجموعةالكاربامازبین


Article
The validity of salivary microRNAs (hsa-miR-200a, hsamiR- 125a and hsa- miR-93) as oral squamous cell carcinoma biomarker

Authors: Shaimaa H. Mudhir --- Raja H. Al-Jubouri رجاء الجبوري --- Ban A. Abdul Majeed
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 3 Pages: 66-71
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Oral squamous cell carcinoma represents the vast majority of oral cancer it is a common malignanttumor with an increasing incidence. Around the world, the 5 year mortality rate of oral cancer is about 50%. Thusnovel biomarkers for early detection oral squamous cell carcinoma are needed. The level of three salivarymicroRNAs namely hsa-miR-200a, hsa-miR-125a and hsa- miR-93 were measured in saliva of patients with oralsquamous cell carcinoma and compared their levels in saliva of healthy control subjects to determine their potentialas oral cancer biomarker.Materials and methods: The level of these three microRNAs was measured by using revers transcription,preamplification and quantitative PCR.Results: Only miR-200a present in a significantly lower level (p<0.05) in the saliva of oral squamous cell carcinomapatients than in control. miR-200a was the strongest parameter (most affected by disease status) in the context ofdifferentiation between OSSC and healthy controls (having the highest ROC area of 0.781 which is significantly higherthan the area associated with equivocal test). Coming next in order of importance in the context of case-controldifferentiation was normalized CT values for hsa-miR-93, which has a reasonably high ROC (0.650), but failed to showstatically significance differences, P>0.05.Conclusions: The detection of miRNAs in saliva can be used as noninvasive and rapid diagnostic tool for thediagnosis of oral cancer

الخلفیة : سرطان الخلایا الحرشفیة للفم یمثل الغالبیة العظمى من سرطان الفم ھو ورم خبیث مع حدوث زیادة في معدلات الاصابة في جمیع أنحاء العالم ، اذ إن معدل الوفی ات 5 س نواتاللعابی ة microRNAs من سرطان الفم ھو حوالي 50 ٪. وبالتالي ھناك حاجة إلى مؤشرات حیویة جدیدة للكشف المبكر عن س رطان الخلای ا الحرش فیة للف م. لق د ت م قی اس مس توى ثلاث ةفي اللعاب من المرضى الذین یعانون من سرطان الخلایا الحرشفیة للفم و مقارنة مستویاتھا في اللع اب م ن مجموع ة اص حاء لتحدی د كفائتھ ا miR-200a, miR-125a, miR- وھي 93والقی اس (preamplification) تض خیم ،(Revers transcription) باستخدام النسخ العكسي microRNAs كعلامات بیولوجیة لسرطان الفم. المواد و الطرق : تم قیاس مستوى ھذه.(Real-time PCR) الكميالمعلم ة الاق وى ( الأكث ر miR-200a ف ي لع اب المرض ى س رطان الخلای ا الحرش فیة للف م مقارن ة م ع مجموع ة الاص حاء. وك ان (p> اق ل بكثی ر ( 0.05 miR-200a النتائج : مستوىم ن 0.781 وھ و أعل ى بكثی ر م ن المنطق ة المرتبط ة ) . المقبل ة القادم ة ف ي ROC و مجموع ة الاص حاء (وج ود أعل ى منطق ة OSSC تضررا من حالة المرض) في سیاق التمایز ب ینP > ، مرتفعة بشكل معقول ( 0.650 ) ، لكنھ فشل في اظھار ثابت ف روق ذات دلال ة ROC والتي لدیھا ، miR- الترتیب من حیث الأھمیة في سیاق الحالات والشواھد في التمایز ھو 93. 0.05في اللعاب كأداة تشخیصیة واسعة وسریعة لتشخیصسرطان الفم. miRNAs الاستنتاجات : یمكن استخدام


Article
Salivary microRNAs (hsa-miR-200a, hsa-miR-125a and hsa- miR-93) in relation to age, gender and histopathological parameters

Authors: Shaimaa H. Mudhir --- Raja H. Al-Jubouri رجاء الجبوري --- Ban A. Abdul Majeed
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 4 Pages: 120-125
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: MicroRNAs (miRNAs) are small noncoding RNAs that post‐transcriptionally regulate gene expression bytargeting specific mRNAs. The main objective of this study was measure the level of salivary (hsa-miR-200a, hsa-miR-125a and hsa- miR-93) in both oral squamous cell carcinoma and healthy controls to asses the association of themwith age, gender and tumor gradematerials and methods The level of three salivary microRNAs namely hsa-miR-200a, hsa-miR-125a and hsa- miR-93were measured in saliva of patients with oral squamous cell carcinoma and healthy controls by using reverestranscription, preamplification and quantitative PCR also the general information from each patient including theage, sex and tumor grade were recorded.Results: Salivary miR-200a was down regulated while miR-93 was up regulated in saliva of females with OSCCcompared to females of healthy control, also there was a weak and statistically insignificant positive linearcorrelation between tumor grade and hsa-miR-200a CT values (r=0.223).However each tumor grade group had amean normalized CT value which was higher than that of controls with statistically significant differences, P<0.05. Theresults suggest that circulating miRNAs may be a biological marker of aging and tumor grade. More studies shouldbe done to validate these results.Conclusions: Both miR-200a and miR-93 could be used as biomarkers for poorly differentiated and aggressive cancer

ان الھ دف الرئیس ي م ن ھ ذه الدراس ة قی اس مس توى .mRNAs ھي الرنا غیر المكودة الصغیرة التي تنظم التعبیر ما بعد النسخ الجیني م ن خ لال اس تھداف microRNAs : خلفیةفي لعاب كل من مرضى سرطان الخلایا الحرشفیة للفم ومجموعة الاصحاء ودراسة علاقة كل منھ ا م ع التق دم ف ي العم ر والج نس ودرج ة (miR-200a, miR-125a, miR-93)ف ي اللع اب م ن المرض ى ال ذین یع انون م ن س رطان الخلای ا الحرش فیة للف م و (miR-200a, miR-125a, miR- اللعابی ة وھ ي ( 93 microRNAs الورم تم قیاس مستوى ثلاث ةأیضا سجلت المعلومات العام ة Real-time PCR و القیاس الكمي preamplification التضخیم ، (Revers transcription) مجموعة الاصحاء باستخدام النسخ العكسيمن كل مریضبما في ذلك السن والجنس و درجة الورم.اعل ى مس توى ف ي اللع اب للإن اث م ن مرض ى س رطان الخلای ا الحرش فیة للف م مقارن ة بالإن اث م ن مجموع ة الا ص حاء، miR- اقل في ح ین 93 miR-200a النتائج : یكون مستوىولك ن ك ان لك ل مجموع ة درج ة ورم ومع دل ، (r =0.223) miR-200a ل CT وأیضا كان ھناك وجود علاقة خطیة إیجابیة ضعیفة وتكاد لا تذكر إحص ائیا ب ین درج ة ال ورم و ق یمق د یك ون علام ة بیولوجی ة لتق دم العم ر ودرج ة ال ورم miRNAs تشیر النتائج إلى أن تعم یم . P < المطبعة أعلى من مجموعة الاصحاء مع فروق ذات دلالة إحصائیة ، 0.05 CT قیمالصف. وینبغي أن یتم المزید من الدراسات للتحقق من صحة ھذه النتائج.یمكن ان تستخدم كمؤشر حیوي لسرطان الخلایا الحرشفیة للفم ذات صفة سیئة التباین والعداونیة. miR- و 93 miR-200a الاستنتاجات : كلا

Keywords

Saliva --- miR-200a --- miR-125a --- miR-93 --- OSCC --- tumor grade --- Real time-PCR


Article
Prevalence of myofascial pain in students of selected secondary schools in Baghdad city

Authors: Toka T. Alnesary --- Rafil H. Rasheed رافل رشيد --- Raja H. AL-Jubouri رجاء الجبوري --- Raya R. Al-Dafaai ريا الدفاعي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: special issue 2 Pages: 84-87
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Myofascial face pain (MFP) is painful disorder of masticatory muscles thought to be the most commontype of temporomandibular disorder (TMD).This study was done to evaluate the prevalence of MFP in students ofsecondary schools of Baghdad cityMaterials and methods: The sample comprised 242 females' students and 222 males' students of secondary schools,aged 17-18 years. The MFP evaluated according to the specific screening questionnaire of research diagnosticcriteria of temporomandibular disorders (RDC/TMD) axis I with clinical examination.Results: the study revealed that (50.8%) of the students had history of pain where females reported higherpercentage than males with statistical significant difference. The history of pain in muscles of mastication was higherthan joint pain in both genders. After clinical examination this study also showed that (25.4%) of students with historyof pain had MFP. The differences between both genders regarding the diagnosis of MFP were higher in females thanmales but statistically not significant.Conclusion: high percentage of students reported a history of pain which could be attributed to MFP in (25.4%) ofthe students. The prevalence of pain history and MFP was higher in females’ than males

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