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Insulin Resistance and Risk of Chronic Renal Impairment in Non and Diabetic Iraqi Adults

Authors: Rana Ali Hamdi --- Manal kamal Rasheed --- Mohammed Kamal Rasheed
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2013 Volume: 6 Issue: 1 Pages: 1514-1524
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Patients with chronic renal impairment (CRI) present a high prevalenceof insulin resistance (IR). Chronic Renal Failure (CRF) is a syndrome of persistentrenal impairment involving loss of glomeruli, tubular and nephron function. Dialysismay be used as a lineal treated to patients who have suddenly but temporarily, lost theirkidney function (acute renal failure) or as a regular region for quite stable patients who havepermanently lost their kidney function.Central obesity, particularly visceral adiposity is considered to play a major role in causinginsulin resistance and type 2 diabetes mellitus. Insulin resistance is characterized by adecrease in the insulin effect on glucose transport in muscle, adipose tissue and liver.Aim of the study: The purpose of this study is to investigate the relationship between thelevel of serum Insulin and Homeostasis model Assessment (HOMA)-Insulin resistance levelsto risk of chronic renal impairment (CRI)Materials and methods:This study include 50 patients (32 males and 18 females) who have chronic renalimpairment disease with and without T2DM aged between (30-70) years, the mean age as(mean± SD) is (56.4± 10.7),(52.8±18.5) years who attended the hemodialysis (HD) at theartificial kidney in AL- Karama Hospital and 30 normal volunteers aged mach with (30-70years)act as control. The mean age is (57±6) years .This study examined the relationshipbetween fasting serum glucose ,insulin ,Homeostasis Model Assessment (HOMA) –Insulinresistance in CRI patients . Insulin was measured by (enzyme immunosorbant assay) .Results: Mean systolic BP and body max index BMI values were significantly higher amongpersons with diabetes compared with their counters without diabetes and control. Diabeticparticipants had higher mean levels of serum glucose, serum insulin, HbA1c and HOMAinsulinresistance compared with non diabetic participants and control. Diabetic participantsalso had a higher prevalence of elevated serum creatinine, urea and cholesterol level withCRI compared with their counterparts without diabetes and control .Conclusion: This study documents the presence of a strong, positive correlation betweeninsulin resistance and chronic renal impairment among non diabetic patients .These datademonstrate that patients with chronic renal impairment have a high prevalence of IR, insulinlevels .

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