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Article
Prevalence of hemoglobinopathies among marrying couples in Erbil province of Iraq

Author: Ranan Kardagh Polus
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2017 Volume: 6 Issue: 2 Pages: 90-93
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

BACKGROUND: Thalassemia is the most common genetic disorders worldwide, widely spreadthroughout the Mediterranean region including Iraq. One effective method to reduce incidence ofthalassemias and sickle cell disease is premarital screening.OBJECTIVE: The aim of this study was to determine the prevalence of β‑thalassemia trait and otherhemoglobinopathies among subjects attending the premarital screening center in Erbil.MATERIALS AND METHODS: Over a period of 1 year, 6224 couples were screened forhemoglobinopathies. Screened subjects were categorized according to the result of completeblood count, serum ferritin, and hemoglobin (Hb) electrophoresis into six groups, namely, normal,β‑thalassemia carriers, α‑thalassemia carriers, sickle cell carriers, Hb‑H (HbH) disease, and irondeficiency anemia.RESULTS: The prevalence of β‑thalassemia trait was 6.94% (864/12448) with nearly equalproportions between male and female (male to female ratio = 1:1.1). HbH disease and sickle celltrait were less common. Iron deficiency anemia was reported in 52 subjects (0.4%).CONCLUSION: We found a relatively high prevalence rate of heterozygous β‑thalassemia among thestudied sample in comparison to prevalence figures from reports in the nearby geographic locations


Article
Prevalence of anemia of chronic disease and iron deficiency anemia among adult diabetic patients in Erbil City
انتشار فقر الدم الناجم عن مرض مزمن وفقر الدم بسبب نقص الحديد بين مرضى السكري البالغين في مدينة أربيل

Authors: Ranan Kardagh Polus --- Abdulqadir Hameed Abdulqadir
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 1 Pages: 674-679
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Anaemia is often an unrecognized complication of diabetes mellitus that has adverse effect on the progression of diabetes related complications. Contributors to its development include erythropoietin insufficiency and iron deficiency. The aim of this study was to assess the prevalence of iron deficiency anaemia and anaemia of chronic disease among diabetic patients.Methods: Over a period of six month from November 2010 to May 2011, 250 diabetic patients, attending Layla Qasim diabetic center were studied, their age ranged between 18-73 years. Venous blood samples were collected from each of them. A complete blood picture, iron study, HbA1c% and fasting blood glucose were performed. According to the duration of diabetes, patients were divided into three groups: group I patients (duration of diabetes < 5 years), group II (duration of diabetes between 5-9 years) and group III (duration of diabetes ≥10 years).Results: One hundred ten patients (44%) were found to have anaemia. The frequency of anaemia was more among group III (46.6%). Higher prevalence of anaemia was found among female patients (53.9%) than male patient (24.1%). Among anemic patients, 72 patients (65%) considered as having anaemia of chronic disease (ACD), 26 patients (24%) were iron deficiency anemia (IDA), 11 patients (10%) were thalassemia trait and one patient (1%) had autoimmune hemolytic anaemia. ACD was more frequent among group II (80%) and group III (70.4%), while IDA was more frequent among group I (12.6%). both ACD and IDA were more frequent among female patient than male patients (34.7% and 13.8% respectively). There was no significant correlation between HbA1c and Hb, serum iron parameters and S.ferritin.Conclusion: It was concluded that anaemia is common among diabetics and remains unrecognized by both physicians and patients; it is more common among female diabetics. The commonest type of anaemia among diabetic patients is ACD followed by IDA.


Article
Clinicopathological, immunohistochemical charachtaristic and the outcome of Hodghkin lymphoma patients in Erbil city, Iraq

Authors: Lilan Bahzad Mohammedzaki --- Kawa Muhammedamin Hasan --- Ranan Kardagh Polus --- Ahmed Khudair Yassin
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2019 Volume: 8 Issue: 1 Pages: 14-20
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

BACKGROUND: Hodgkin lymphoma (HL) has unique epidemiological features with diversifiedpathologies and exhibits considerable clinicopathological variations in different parts of the world.OBJECTIVES: We aimed in this study to assess clinic-pathological features, immunohistochemistryand outcome of HL patients treated in Erbil, northren Iraq.PATIENTS AND METHODS: This was a retrospective study conducted in Nanakaly Hospital forblood diseases and oncology in Erbil, North Iraq; a total of 125 patients diagnosed between January2012 and December 2016 were involved; they were assessed for their clinical characteristics andhistopathology and immunophenotyping findings and their outcome was evaluated as well.RESULTS: The median age was 28 years (range: 18–71 years); 55% were male and 41% had StageII disease; common histological type is nodular sclerosis (51.2%) followed by mixed cellularity (43.2%);CD30 was positive in nearly all cases of classical HL, and CD15 was positive in 98.7% and CD20was positive in 75% in nodular lymphocyte predominant subtype. Most of the patients receivedadriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy, and the 5‑year overall survivalin our study is 70%. Advanced stage (IV), high lactate dehydrogenase level, low hemoglobin, andsplenomegaly are significant predictors for poor survival.CONCLUSION: Our patient exhibited outcomes that were lower to those reported in developedcountries.


Article
Assessment of Thyroid Function in patients with β- Thalassaimia Major and Intermedia: A comparative Study
تقييم فحص وظيفة الغدة الرقية في مرضى الثالاسيميا الكبرى والثالاسيميا الوسطي: دراسة مقارنة بينهما

Authors: Ranan Kardagh Polus رنان قرداغ بولص --- Jamila Abdulsalam Abdulla جميلة عبد السلام عبد الله
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2019 Volume: 17 Issue: 2 Pages: 115-126
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Thalassemia is regarded as one of the most common hereditary disorders throughout the world. Endocrine disorders found among the commonest complications in thalassemic patients resulting from iron overload, especially thyroid. Objective: To investigate thyroid function and complications in patients with Beta thalassemia major and intermedia in Erbil city. Patients and Methods: This is prospective, cross sectional study (comparative study), the study was extended from September of 2018 till October of 2019 on 71 beta thalassemia major and 49 intermedia patients. The study was performed in the thalassemia center in Erbil city. Assay of thyroid hormones (thyroid function test) was performed by Roche Cobas E411 analyzer is fully automated immunoassay analyzer. Data were analyzed by using the statistical package for social science (SPSS) version22.Results: This retrospective cross sectional study was carried out on 196 subjects, from which 71 patients with thalasseamia major ,49 patients with thalassemia intermedia, and 78 case were control subject.in the thalassemia major 8 cases (11.3) % had hypothyroidism (TSH high and low T4) and 17 case (23.9) % were subclinical hypothyroidism (TSH high and T3 AND T4 normal), in intermedia group about 13 patients had subclinical hypothyroidism, in compared to control group about 3 (3.9) % subclinical. In both TI and TMthy, the proportion of hypothyroidism and subclinical hypothyroidism was significantly (P=0.037) higher in those 18 years old (38.9%) compared to the lower age group (20.8%). Conclusion: The thyroid function did not differ significantly by the other characteristics of the patients such as gender, consanguinity, chelation therapy, splenectomy status, organomegllay, BMI. Serum ferritin was found to be positively, but non-significantly correlated with T3 (r=0.78, p=0.398), negatively and significant statistically correlated with T4 (r=-0.231, p=0.011) and positively and significant statistically correlated with TSH (r=253, p=0.005).

خلفية الدراسة: تعتبر الثلاسيميا واحدة من أكثر الاضطرابات الصحية شيوعاً في جميع أنحاء العالم. اضطرابات الغدد الصماء موجودة بين أكثر المضاعفات شيوعا في مرضى الثلاسيميا الناتجة عن زيادة في تركيز عنصر الحديد وخاصة في الغدة الدرقية.اهداف الدراسة: التحقق في وظائف الغدة الدرقية ومضاعفاتها لدى مرضى البيتا ثلاسيميا الكبرى (Beta Thalassemia major ) والوسطية (Internationat) في مدينة أربيل.المرضى والطرائق: هذه دراسة مستقبلية مستعرضة (دراسة مقارنة) ، وتم بدأ الدراسة من سبتمبر 2018 حتى أكتوبر 2019 على 71 بيتا ثلاسيميا الكبرى ( Beta thalassemia major) و 49 مريض (Internationat) . أجريت الدراسة في مركز الثلاسيميا في مدينة أربيل. ثم إجرى فحص هرمونات الغدة الدرقية (اختبار وظائف الغدة الدرقية) بواسطة محلل Roche Cobas E411 وهو محلل مقايسة مناعية مؤتمتة بالكامل. تم تحليل البيانات باستخدام الحزمة الإحصائية للعلوم الاجتماعية (SPSS) الإصدار 22.النتائج: وقد أجريت هذه الدراسة المقطعية بأثر رجعي (retrospective cross sectional study )على 196 من المرضى ، منها 71 مريضا بالثلاسيميا الكبرى ، و 49 مريضا بالثلاسيميا البينية ، و 78 حالة مجموعة السيطرة . من حالات الثلاسيميا الكبرى 8 حالات (11.3) ٪ يعانون من قصور الغدة الدرقية ( TSH high and low T4) )،،و17 حالة (23.9) ٪ قصور في الدرقية (ارتفاع TSH و T3 و T4 طبيعي) ، في المجموعة (الثالاسيميا البينية ) كان حوالي 13 مريضا يعانون من قصور الدرقية تحت الإكلينيكي (sub clinical) ، مقارنة بمجموعة السيطرة حوالي 3 (3.9) ٪ تحت الإكلينيكي. في كل من TI و TM thy ، كانت نسبة قصور الغدة الغدة الدرقية تحت الإكلينيكي أعلى بشكل ملحوظ (P = 0.037) في تلك الفئة العمرية 18 عامًا (38.9٪) مقارنةً بالمجموعة العمرية الأدنى (20.8٪).الاستنتاجات : لم تختلف وظيفة الغدة الدرقية اختلافًا كبيرًا حسب الخصائص الأخرى للمرضى مثل الجنس ، القرابة ، ازالة معدن ثقيل ، حالة استئصال الطحال ، التورم العضوي ، مؤشر كتلة الجسم (BMI ) . تم العثور على مصل الفيريتين بشكل إيجابي ، ولكن غير مرتبط بشكل كبير مع T3 (r = 0.78 ، p = 0.398) ، يرتبط ارتباطًا سلبيًا وهامًا إحصائيًا بـ T4 (r = -0.231 ، p = 0.011) ومتصل إحصائيًا وهامًا مع TSH (ص = 253 ، ع = 0.005).

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