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Association of factor V Leiden mutation with retinal vein thrombosis in a set of Iraqi patients

Authors: Rehab Abdul Sahb Al‑Waeli --- Rahem Mahdy Rahem
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2016 Volume: 5 Issue: 2 Pages: 157-160
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:BACKGROUND: Retinal vein occlusion is the most common retinal vascular disorder after diabetic retinopathywith several ocular and systemic disorders associated with retinal veins thrombosis. Factor V Leiden (FVL)mutation as part of inherited thrombophilia may associated with retinal vein thrombosis.OBJECTIVES: Determine the presence of FVL mutation in a set of Iraqi patients with retinal vein thrombosisand evaluate its role in the etiology of thrombosis in those patients.PATIENTS, MATERIALS AND METHODS: A case–control study conducted for 6 months, a total number of69 patients who were diagnosed with retinal vein thrombosis while attending ophthalmology outpatient clinic inDiwania city in Iraq. Only sixty patients were eligible for the study. From each patient, venous blood was withdrawnfor complete blood count, blood film, erythrocyte sedimentation rate, kaolin clotting time, anticardiolipin antibodies,antinuclear antibody, thyroid‑stimulating hormone, renal function test, random blood sugar, and serum cholesterolin addition to determine the presence of FVL mutation by polymerase chain reaction (PCR)‑restriction fragmentlength polymorphism. For 84 individuals of control group, only the presence of FVL mutation by PCR was done.RESULTS: Sixty out of 69 patients with retinal vein thrombosis were eligible for the study. There were a total of34 males and 26 females with a mean age of 49.1 ± 2.03 years with no significant statistical differences in meanage and sex between the patients and the control groups. The proportion of patients with FVL mutation washigher than that of control subjects, 21.7% versus 8.3% (P = 0.023). FVL mutation in patients group showing asignificant risk factor to develop retinal vein thrombosis than control group (odd ratio: 3.043).CONCLUSIONS: FVL plays a role in etiology of retinal vein thrombosis and measurement of this mutation withproper prophylaxis may be useful in prevention of venous thrombosis.


Article
Inherited thrombophilia: Diagnostic approach

Authors: Rahem Mahdy Rahem --- Rehab Abdul Sahb Al‑Waeli
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2017 Volume: 6 Issue: 2 Pages: 31-37
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Hemostatic abnormalities include both bleeding and thrombosis disorders. Adherence to mostcommon guidelines for the diagnosis of thrombophilia is recommended especially in some developingcountries. High level of orientation to thrombophilic disorders needs wide spectrum of knowledgeabout the causes, primary or secondary, investigations to most common risk factors, selectingcandidates to investigations, in addition to covering the possibility of multifactorial background ofdisease. Limited data are available that focus on the thrombophilic disorders with imperfect diagnosticcooperation between clinical and laboratory aspects to reach the full picture of these hemostaticabnormalities. In this short review of literature, we considered the most important publications thatassessed the inherited thrombophilia at levels of presentation, diagnosis, and management withfocus on the practical side. The aim of this review is to summarize the most important aspects ofthe thrombophilia presentation, inherited causes, indications for testing, and investigations requiredfor thrombophilic patients

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