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Article
Induction of Microsomal Liver Enzymes by Silymarin in Experimental Animals

Authors: Bahir A.R. Mshiemish --- Bahir A.R. Mshiemish --- Bahir A.R. Mshiemish --- Saad A. R. Hussain --- et al.
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2011 Volume: 53 Issue: 2 Pages: 233-235
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: previous researches showed that the hepatoprotective effect of silymarin was through inhibition of cytochrome p450- system (e.g. protection against Amanita toxin), in addition to protection from free radicals generated by this enzymatic system. In contrast to that, many evidences clarified that silymarin may increase first pass metabolism of e.g. cyclosporine and benzodiazepenes. Objective: Our aim from this animal experiment was to relieve this confusion and detect that this herbal extract is absolutely hepatoprotective or induce hepatotoxicity in other conditions.
Materials and Methods: this study was performed on 15 healthy male rats randomized into two treatment groups; first group (5 rats) pretreated with phenobarbital (I.P) then given acetaminophen (I.P) and the second group (5 rats) pretreated with silymarin (orally) then given acetaminophen (I.P.); while the last five rats were considered as control group for comparison . Activities of SGOT, SGPT and histopathological sections were detected for both groups and compared with that of control.
Results: for both treatment groups, the activities of transaminase enzymes were significantly higher than control group. Meanwhile; activity of these enzymes and severity of hepatic damage were significantly higher for Phenobarbital group compared with silymarin.
Conclusion: we can conclude from this experimental study that, even though silymarin act as hepatoprotective by multifactorial mechanisms (antioxidant, increase glutathione level, antifibrotic, anti-inflammatory and enzyme inhibitor), it may act as enhancer for some hepatotoxic agents (like acetaminophen) by cytochrome P-450 induction mechanism.


Article
The Effect of Radiotherapy on Oxidative Stress, Biochemical and Hematological Parameters inWomen with Breast Cancer
تأثیر العلاج الاشعاعي على مقیاس الاجھاد التاكسدي وبعض معایر الدم في النساء المصابات بسرطان الثدي

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Abstract

Abstract:This study was designed to evaluate the effect of radiation therapy on the oxidativestress, biochemical and hematological parameters in women with breast cancer. 95 womenwere studied, 20 healthy control women and 75 had breast cancer.Malondialdehyde and glutathione (in erythrocytes and plasma), biochemicalparameters (total plasma proteins, plasma albumin, uric acid and plasma calcium) levels, andhematological parameters (hemoglobin, white blood cell counts, platelets counts) allparameters were measured pre- and post radiation therapy for 4 weeks.The result of this study indicates that the incorporation of radiation therapy as a way todestroy malignant cells, in addition to their therapeutic benefits, it may lead to further increasein the oxidative stress burden of cancer, manifested by increase in MDA production andglutathione depletion. Which may affect directly or indirectly some biochemical andhematological parameters as indicated by lowering plasma protein especially albumin,increases in plasma calcium level, and decreases in hemoglobin, white blood cells, andplatelets levels.These changes should be considered during radiation therapy and beforeadministration of anticancer drugs or any other drugs because it may affect both the beneficialas well as the toxicity of these drugs.Key words: radiation therapy, breast cancer, oxidative stress parameters, total plasmaproteins, plasma albumin, uric acid, plasma calcium, hemoglobin, white blood cell counts,and platelets counts.

الخلاصة:أجریت ھذه الدراسة لمعرفة تأثیر سرطان الثدي والمعالجة الاشعاعیة على الاجھاد التأكسدي وبعض معاییرالكیمیاء الحیویة والدمویة في المرضى المصابین بسرطان الثدي قبل وبعد المعالجة الاشعاعیة. أجریت ھذه الدراسة على95 أمرأة ( 20 أصحاء و 75 مصابات بسرطان الثدي). بینت الدراسة زیادة في الاجھاد التأكسدي في مرضى سرطان الثدي(زیادة المالون داي الدھایت ونقصان في الكلوتاثایون) في بلازما الدم وكریات الدم الحمراء. ولوحظ بان العلاج الاشعاعيیزید من حالة الاجھاد التأكسدي للمرضى.أظھرت النتائج نقصان في مستوى بروتینات الدم وخاصة الالبومین وھذا النقصان یزداد مع العلاج الاشعاعي.ولوحظ أیضا زیادة في مستوى الكالسیوم وحامض البول في دم المرضى وان العلاج الاشعاعي یزید من ارتفاع مستوىالكالسیوم في الدم. كما لوحظ ایضا انخفاض في مستوى الھیموكلوبین وكریات الدم البیضاء في المرضى وان العلاجالاشعاعي یزید من ھذا النقصان اضافة الى حدوث نقص في عدد الصفائح الدمویة. ھذه التغیرات التي تحدث في مرضى

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